DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5955 and UXS1

DIOPT Version :9

Sequence 1:	NP_649230.1	Gene:	CG5955 / 40268	FlyBaseID:	FBgn0036997	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001240804.1	Gene:	UXS1 / 80146	HGNCID:	17729	Length:	425	Species:	Homo sapiens

Alignment Length:	273	Identity:	61/273 - (22%)
Similarity:	114/273 - (41%)	Gaps:	40/273 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KILITGGLGQLGIECAKLLRTQYGSQNVILSDIIKPSQSVLEN--GPYIFADILDFKGLQKIVVD 109
            :||||||.|.:|......|... |.:..::.:.....:..:|:  |...| ::::...::.:.::
Human    95 RILITGGAGFVGSHLTDKLMMD-GHEVTVVDNFFTGRKRNVEHWIGHENF-ELINHDVVEPLYIE 157

  Fly   110 HRIDWLIHFSALLSAVGEQNVPL-AVRVNIEGVHNVIELAKQYKLRIFVPSTIGAFGPDSPRNPT 173
              :|.:.|.::..|.......|: .::.|..|..|::.|||:...|:.:.||...:| |...:|.
Human   158 --VDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYG-DPEVHPQ 219

  Fly   174 P-----NVTIQRPRTIYGVSKVHAELIGEYYYHKFGLDFRCLRF-----PGVISSDPPGGGTTDY 228
            .     :|....||..|...|..||.:...|..:.|::.|..|.     |.:..:|  |...:::
Human   220 SEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMND--GRVVSNF 282

  Fly   229 AVAVFHEALRNGKYTCYLRPDTRLPMMYIEDCLRALLEFMRAPNEQLKRRVYNVTA--MSFTPEE 291
            .:    :||:....|.|..........|:.|.:..|:..|.:          ||::  ....|||
Human   283 IL----QALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNS----------NVSSPVNLGNPEE 333

  Fly   292 ----LFAQLGKHV 300
                .||||.|::
Human   334 HTILEFAQLIKNL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5955	NP_649230.1	WcaG	47..355	CDD:223528	61/273 (22%)
CG5955	NP_649230.1	TDH_SDR_e	47..351	CDD:187580	61/273 (22%)
UXS1	NP_001240804.1	UXS1_N	4..83	CDD:288636
		WcaG	94..401	CDD:223528	61/273 (22%)
		UGD_SDR_e	94..397	CDD:187541	61/273 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810