Protein Alignment Tdh and MAT2B

DIOPT Version :10

• Sequence 1: NP_649230.1
• Gene: Tdh / 40268
• FlyBaseID: FBgn0036997
• Length: 367
• Species: Drosophila melanogaster
• Sequence 2: NP_037415.1
• Gene: MAT2B / 27430
• HGNCID: 6905
• Length: 334
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 57/304 - (18%)
• Similarity: 99/304 - (32%)
• Gaps: 105/304 - (34%)

  Fly    25 PIASQLVQRRAFHQVPRESRPPKILITGGLGQLGIECAKLLRTQYGSQN-VILSDIIKPSQSVLE 88
            |.:.:||:...  .:|..    ::|:||..|.||    :.:..::...| ..:....:.::...|
Human    14 PGSCRLVEEEV--NIPNR----RVLVTGATGLLG----RAVHKEFQQNNWHAVGCGFRRARPKFE 68

  Fly    89 NGPYIFADILDFKGLQKIVVDHRIDWLIHFSALLSAVGEQNVP-LAVRVNIEGVHNVIELAKQYK 152
            .     .::||...:..|:.|.:...::|.:|.......:|.| .|.::|::...|   |||:
Human    69 Q-----VNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGN---LAKE-- 123

  Fly   153 LRIFVPSTIGAF--------GPDSPRNPTPNVTIQRPRTIYGVSKVHAE---------------- 193
                 .:.:|||        ..|....|.....|..|..:||.:|:..|
Human   124 -----AAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIP 183

  Fly   194 -LIGE-----------------YYYHKFGLDFRCLRFPGVISS--------------DPPGGGTT 226
             |.||                 :......:|....|||..:..              ||...||
Human   184 ILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGT- 247

  Fly   227 DYAVAVFH----EALRNGKYTC-----------YLRPDTRLPMM 255
                  ||    |.:...:..|           :|||.|..|::
Human   248 ------FHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVL 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdh	NP_649230.1	TDH_SDR_e	47..351	CDD:187580	53/282 (19%)
MAT2B	NP_037415.1	dTDP_HR_like_SDR_e	30..316	CDD:187564	53/282 (19%)
		Required for interaction with MAT2A. /evidence=ECO:0000269|PubMed:25075345	319..334