DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5955 and MAT2B

DIOPT Version :9

Sequence 1:	NP_649230.1	Gene:	CG5955 / 40268	FlyBaseID:	FBgn0036997	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_037415.1	Gene:	MAT2B / 27430	HGNCID:	6905	Length:	334	Species:	Homo sapiens

Alignment Length:	304	Identity:	57/304 - (18%)
Similarity:	99/304 - (32%)	Gaps:	105/304 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PIASQLVQRRAFHQVPRESRPPKILITGGLGQLGIECAKLLRTQYGSQN-VILSDIIKPSQSVLE 88
            |.:.:||:...  .:|..    ::|:||..|.||    :.:..::...| ..:....:.::...|
Human    14 PGSCRLVEEEV--NIPNR----RVLVTGATGLLG----RAVHKEFQQNNWHAVGCGFRRARPKFE 68

  Fly    89 NGPYIFADILDFKGLQKIVVDHRIDWLIHFSALLSAVGEQNVP-LAVRVNIEGVHNVIELAKQYK 152
            .     .::||...:..|:.|.:...::|.:|.......:|.| .|.::|::...|   |||:
Human    69 Q-----VNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGN---LAKE-- 123

  Fly   153 LRIFVPSTIGAF--------GPDSPRNPTPNVTIQRPRTIYGVSKVHAE---------------- 193
                 .:.:|||        ..|....|.....|..|..:||.:|:..|
Human   124 -----AAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIP 183

  Fly   194 -LIGE-----------------YYYHKFGLDFRCLRFPGVISS--------------DPPGGGTT 226
             |.||                 :......:|....|||..:..              ||...||
Human   184 ILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGT- 247

  Fly   227 DYAVAVFH----EALRNGKYTC-----------YLRPDTRLPMM 255
                  ||    |.:...:..|           :|||.|..|::
Human   248 ------FHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVL 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5955	NP_649230.1	WcaG	47..355	CDD:223528	53/282 (19%)
CG5955	NP_649230.1	TDH_SDR_e	47..351	CDD:187580	53/282 (19%)
MAT2B	NP_037415.1	dTDP_HR_like_SDR_e	30..316	CDD:187564	53/282 (19%)
MAT2B	NP_037415.1	Required for interaction with MAT2A. /evidence=ECO:0000269\|PubMed:25075345	319..334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0451
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900