Protein Alignment Tdh and hsd-2

DIOPT Version :10

• Sequence 1: NP_649230.1
• Gene: Tdh / 40268
• FlyBaseID: FBgn0036997
• Length: 367
• Species: Drosophila melanogaster
• Sequence 2: NP_508851.1
• Gene: hsd-2 / 191049
• WormBaseID: WBGene00022498
• Length: 374
• Species: Caenorhabditis elegans
• Alignment Length: 298
• Identity: 77/298 - (25%)
• Similarity: 111/298 - (37%)
• Gaps: 67/298 - (22%)

  Fly    49 LITGGLGQLGIECAKLLRTQYGSQNVILSD-------IIKPSQSVLENGPYIFADILDFKGLQKI 106
            :|.||.|.||......|:.....:.:|:.|       .||..:|   |..||.|..||.|.|:.|
 Worm     5 VIVGGGGFLGAHVISALQKIGCKERIIVVDPCPQEFKTIKIDKS---NISYIKASFLDDKVLENI 66

  Fly   107 VVDHRIDWLIHFSALLSAVGEQNVPLAVR-----VNIEGVHNVIELAKQYKLRIFV------PST 160
            :  :....::|    |:|||...:....|     .|:.|...:|:..|...::.|:      .|.
 Worm    67 L--NGASAVVH----LAAVGHTGLIAGDRKSVHNFNVNGTKQLIKQCKALGVKRFLYASSVAVSF 125

  Fly   161 IGAFGPDSPRNPTPNVTIQRP-------RTIYGVSKVHAELIGEYYYHKFGLDFR--CLRFPGVI 216
            ||        .|..|||...|       ...|..||..||   .|...:...||:  ||||.|:.
 Worm   126 IG--------EPLDNVTEDDPLPDPKKYLDFYSASKAEAE---TYVLSQSTPDFKTVCLRFRGIY 179

  Fly   217 SSDPPGGGTTDYAVAVFHEALRNGKYTCYLRPDTRLPMMYIE---DCLR--ALLEFMRAPNEQLK 276
            ..:.|   .....||   ..::||.:...:....|..:....   :|.:  ||.:.|....:.|.
 Worm   180 GPEDP---NVTLKVA---NLIKNGLFIGMVSAHGRESVSCASSGVNCAKAFALADQMLQNPDGLH 238

  Fly   277 RRVY------NVTAMSF-TPEELFAQLGKHVPNLHVTY 307
            .|.|      ||....| ||  |...|||..|:.:..|
 Worm   239 GRAYYILDGENVGQFQFWTP--LVLALGKQPPSFYTPY 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdh	NP_649230.1	TDH_SDR_e	47..351	CDD:187580	77/298 (26%)
hsd-2	NP_508851.1	Rossmann-fold NAD(P)(+)-binding proteins	5..327	CDD:473865	77/298 (26%)