Protein Alignment Tdh and Hsd3b6

DIOPT Version :10

• Sequence 1: NP_649230.1
• Gene: Tdh / 40268
• FlyBaseID: FBgn0036997
• Length: 367
• Species: Drosophila melanogaster
• Sequence 2: NP_038849.2
• Gene: Hsd3b6 / 15497
• MGIID: 109598
• Length: 373
• Species: Mus musculus
• Alignment Length: 347
• Identity: 76/347 - (21%)
• Similarity: 123/347 - (35%)
• Gaps: 96/347 - (27%)

  Fly    49 LITGGLGQLGIECAKLLRTQYGSQNV-ILSDIIKPSQ-------------SVLENGPYIFADILD 99
            |:||..|.||....:||..:...:.: :|....:|..             :|||      .||||
Mouse     7 LVTGAGGFLGQRIVQLLMQEKDLEEIRVLDKFFRPETREQFFNLDTNIKVTVLE------GDILD 65

  Fly   100 FKGLQKIVVDHRIDWLIHFSALLSAVGEQNVPLAVRVNIEGVHNVIELAKQYKLRIFV-PSTIGA 163
            .:.|:|..  ..|..:||.:|::...|.......:.||::|..|::|...|..:..|: .|::..
Mouse    66 TQYLRKAC--QGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDV 128

  Fly   164 FGPDSPRNPTPNVTIQRPRTIYGVSKVHAELI--GEYYYHKFGLDFRCLRFPGVISSDPPGGGTT 226
            .||:|.:....|          |..:.|.|.|  ..|.|.|...:...|...|.:...   |||.
Mouse   129 AGPNSYKEIILN----------GNEEEHHESIWSDPYPYSKKMAEKAVLAANGSMLKI---GGTL 180

  Fly   227 DYAVAVFHEALRNGKYTCYLRP----DTRLPMMYIEDCLRALLEFMRAPNEQLKRRVYNVTAMSF 287
                           :||.|||    ..|.|  :|.:.:...|:         .:.:...|....
Mouse   181 ---------------HTCALRPMYIYGERSP--FISNTIITALK---------NKNILGCTGKFS 219

  Fly   288 TPEELF----------AQLG----KHVPNLHVTYKPDSRQLIADAWP-QVFDDSD--ARRDW--- 332
            |...::          |..|    |..||:...:     ..|:|..| |.:||.:  ..::|
Mouse   220 TANPVYVGNVAWAHILAARGLRDPKKSPNIQGEF-----YYISDDTPHQSYDDLNYTLSKEWGFC 279

  Fly   333 ---HWQHKYDLSNLVDFMIKDV 351
               .|.....|...:.||::.|
Mouse   280 PDSSWSLPVPLLYWLAFMLETV 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdh	NP_649230.1	TDH_SDR_e	47..351	CDD:187580	75/345 (22%)
Hsd3b6	NP_038849.2	Rossmann-fold NAD(P)(+)-binding proteins	5..357	CDD:473865	76/347 (22%)