DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mag and LIPM

DIOPT Version :9

Sequence 1:	NP_649229.1	Gene:	mag / 40267	FlyBaseID:	FBgn0036996	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_011538050.1	Gene:	LIPM / 340654	HGNCID:	23455	Length:	430	Species:	Homo sapiens

Alignment Length:	396	Identity:	135/396 - (34%)
Similarity:	207/396 - (52%)	Gaps:	41/396 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LSEIVKSDERIRSHGYPTETHEVTTQDGYVLTLFRIPYSHKLKNQNEKRPPILLQHGLFSNSDCW 90
            :|||      |:..|||.|.:||.|:|||:|::.|||.......:...||.:||||||...:..|
Human    49 ISEI------IQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNW 107

  Fly    91 LSSGPDNSLAYLLADAGYDVWLGNARGNIYSRNNIIISLNSHKFWHFDWHEIGTIDIPAMIDYIL 155
            :|:.|:|||.::|||||:|||:||:|||.:||.:..:|::..:||.|.:.|:...|:||:|::||
Human   108 ISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFIL 172

  Fly   156 ADTGFDQIHYAGHSQGTTVYLVMLSERPEYNALIKSGHLLAPCAFFEH----GTSFIFNALGPLV 216
            ..||.::|:|.|:|||||:..:..|..||....||....|||.|..:|    ||.|:.
Human   173 QKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTKFLL------- 230

  Fly   217 GTPGGIWNQLLVDTELIPNNNLVNRLVDNSCH--LSNTICNNAFIMFANGGYVNANASSMSV--L 277
             .|..:...|....|.:.....:.:||...|.  :.:.||:|  ||...||: |.|..:|:.  |
Human   231 -LPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQVILDQICSN--IMLLLGGF-NTNNMNMNTHGL 291

  Fly   278 IETHP--------AGSSSNQGIHYLQLWKSLKFRQYDWGTK-KNNELYGQDLPPDYDLSKIVAPT 333
            :::..        ||:|....:|:.|...|.:.|.:|||:: ||.|...|..|..|.:..:..||
Human   292 LQSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMTVPT 356

  Fly   334 HLYSSTNDALCGPEDVNTLVENFPHLTEDYRVPVQSFNHLDFIIAKNMKELVNDPII-----ERI 393
            .:::...|.|..||||..|:....:|.  |...:..:.|:|||...:....:.:.||     |..
Human   357 AMWTGGQDWLSNPEDVKMLLSEVTNLI--YHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMQQEET 419

  Fly   394 NSYEGR 399
            |..:||
Human   420 NLSQGR 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mag	NP_649229.1	Abhydro_lipase	34..94	CDD:282003	25/59 (42%)
		MhpC	56..366	CDD:223669	111/326 (34%)
		Abhydrolase_5	76..>197	CDD:289465	54/120 (45%)
LIPM	XP_011538050.1	Abhydro_lipase	49..111	CDD:282003	28/67 (42%)
		Abhydrolase_1	92..399	CDD:278959	110/319 (34%)
		Abhydrolase_5	93..>231	CDD:289465	61/145 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141772
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910