DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment atk and MMT2

DIOPT Version :9

Sequence 1:	NP_001262113.1	Gene:	atk / 40266	FlyBaseID:	FBgn0036995	Length:	1535	Species:	Drosophila melanogaster
Sequence 2:	NP_015100.2	Gene:	MMT2 / 855877	SGDID:	S000006145	Length:	484	Species:	Saccharomyces cerevisiae

Alignment Length:	410	Identity:	85/410 - (20%)
Similarity:	162/410 - (39%)	Gaps:	106/410 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SHSNL---PQIMDGLKAVERNIKGRIDELVLENNQLPALPGRFFGSLQIVRLMLRHNSIERVSNG 106
            ||:::   |.:...::.:::|...||..:.|.:|...|: |:|.|.:......|..:|:..
Yeast   107 SHTHMHDNPLLSLNVQQIKKNPGVRITWIGLASNVGMAV-GKFVGGITFHSQALLADSVHA---- 166

  Fly   107 WLNELENGLVEIFVVEPQLRSIPAE--------------SLNGMINMLAITIQSEELKHLPDFSG 157
             |::|.:..:.:|.|:...|...:|              :::.::.|..|:|         .:|.
Yeast   167 -LSDLVSDFLTLFSVQYASRKPTSEYPYGYGKVETVGSLAVSTILAMAGISI---------GWSS 221

  Fly   158 LLSL-------TYLSVQTGALQELPSH---LFRHLPKLQHIHITGGSGLTR---LEAGLFDGLIS 209
            |.::       ..|....|.:.|..||   |.:....:..:.|..||.|.:   .:|.....:.:
Yeast   222 LCAIVGPVIPHAILESMAGLIGETHSHSQSLTQQATNVNAVWIAAGSILVKEWVFQATKKVAIQT 286

  Fly   210 LKNLDLSHNGLNWIH-LRALSRLPNLVSLKLSH----NQISDVG---MVGRIVKD-----LEHLK 261
            ..|:.:::   .|.| :.:|:.|..||::..|:    ..:.::|   :.|.|:|.     |..||
Yeast   287 NSNVLMAN---AWHHRVDSLTSLVALVAITSSYFFNIQSLDNLGGLVVSGLIIKTGGQGILSSLK 348

  Fly   262 KLRLDNN----------LITVIED--GSF-VDLPNLSELHLNDNRITELQYGAFLR-TPQLKTIY 312
            :| :|.:          :.:||:|  ||. .||.....||:.|  :|.|..|..|| |..|:...
Yeast   349 EL-VDQSIPPTDPRYLEIESVIKDSIGSLKTDLDLKQSLHVRD--LTILASGPNLRATTTLEVPV 410

  Fly   313 LQNNLIRRIHPESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGA 377
            |.:.  :.:....|..|..:..|.:.|....:|.|:           :.::|::.:
Yeast   411 LHSG--QEVGIRFLENAISTIREDLRMKVPNVGKVD-----------VEFVDVTSD--------- 453

  Fly   378 LRGHGTLEQLH----LNHNH 393
              ..|.||..|    .||.|
Yeast   454 --SKGDLEHSHDTKSTNHTH 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atk	NP_001262113.1	leucine-rich repeat	69..89	CDD:275380	6/19 (32%)
		leucine-rich repeat	90..113	CDD:275380	4/22 (18%)
		leucine-rich repeat	115..138	CDD:275380	4/36 (11%)
		leucine-rich repeat	139..160	CDD:275380	5/20 (25%)
		leucine-rich repeat	161..184	CDD:275380	6/32 (19%)
		LRR_8	183..244	CDD:290566	13/68 (19%)
		leucine-rich repeat	185..209	CDD:275380	5/26 (19%)
		LRR_4	209..247	CDD:289563	8/42 (19%)
		leucine-rich repeat	210..233	CDD:275380	5/23 (22%)
		leucine-rich repeat	234..259	CDD:275380	8/36 (22%)
		LRR_RI	250..492	CDD:238064	40/167 (24%)
		LRR_8	259..318	CDD:290566	22/72 (31%)
		leucine-rich repeat	260..283	CDD:275380	11/35 (31%)
		leucine-rich repeat	284..307	CDD:275380	9/23 (39%)
		leucine-rich repeat	308..359	CDD:275380	8/50 (16%)
		leucine-rich repeat	334..348	CDD:275378	3/13 (23%)
		LRR_8	358..418	CDD:290566	8/40 (20%)
		leucine-rich repeat	360..383	CDD:275380	1/22 (5%)
		leucine-rich repeat	384..407	CDD:275380	6/14 (43%)
		LRR_8	406..466	CDD:290566
		leucine-rich repeat	408..431	CDD:275380
		leucine-rich repeat	432..455	CDD:275380
		LRR_RI	447..705	CDD:238064
		LRR_8	454..514	CDD:290566
		leucine-rich repeat	456..476	CDD:275380
		leucine-rich repeat	480..501	CDD:275380
		leucine-rich repeat	505..517	CDD:275378
		leucine-rich repeat	525..550	CDD:275380
		LRR_8	549..609	CDD:290566
		leucine-rich repeat	551..574	CDD:275380
		leucine-rich repeat	575..598	CDD:275380
		leucine-rich repeat	599..622	CDD:275380
		LRR_8	622..681	CDD:290566
		leucine-rich repeat	623..646	CDD:275380
		LRR_RI	647..896	CDD:238064
		leucine-rich repeat	647..670	CDD:275380
		leucine-rich repeat	671..693	CDD:275380
		leucine-rich repeat	694..717	CDD:275380
		LRR_8	716..776	CDD:290566
		leucine-rich repeat	718..741	CDD:275380
		leucine-rich repeat	742..763	CDD:275380
		LRR_8	765..824	CDD:290566
		leucine-rich repeat	766..789	CDD:275380
		leucine-rich repeat	790..813	CDD:275380
		leucine-rich repeat	814..835	CDD:275380
		leucine-rich repeat	838..861	CDD:275380
		LRR_8	862..921	CDD:290566
		leucine-rich repeat	862..885	CDD:275380
		leucine-rich repeat	886..906	CDD:275380
		TPKR_C2	919..>946	CDD:301599
MMT2	NP_015100.2	FieF	122..409	CDD:223131	67/307 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000