DRSC/TRiP Functional Genomics Resources

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Protein Alignment atk and CYR1

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_012529.3 Gene:CYR1 / 853452 SGDID:S000003542 Length:2026 Species:Saccharomyces cerevisiae


Alignment Length:760 Identity:174/760 - (22%)
Similarity:302/760 - (39%) Gaps:178/760 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 PSHLF----RHLPKLQHIHI-TGGSGLTRLEAGLFDGLISLKNLDLSHNGLNWIHLRALSRLPNL 234
            |||..    :.:.:.:.:|: .....||......:.....:::||:|:|...::.|..:.....|
Yeast   778 PSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKL 842

  Fly   235 VSLKLSHNQISDVGMVGRIVKDLEHLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDNRITELQY 299
            :||::.:.:.|.  ....|.|..: |..|.|..|.|..:.: |.:.|.||:.|:|..|.:..|..
Yeast   843 LSLRMVNIRASK--FPSNITKAYK-LVSLELQRNFIRKVPN-SIMKLSNLTILNLQCNELESLPA 903

  Fly   300 GAFLRTPQLKTIYLQNNLIRRIHPESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLD 364
            | |:....|:.:.|.:|.... :||                            :::....|..:|
Yeast   904 G-FVELKNLQLLDLSSNKFMH-YPE----------------------------VINYCTNLLQID 938

  Fly   365 MSGNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWNL 429
            :|.|.:..||. :.:....|.:::|:||.|..|  ..|..|..||.|.:|.|.:||...    |.
Yeast   939 LSYNKIQSLPQ-STKYLVKLAKMNLSHNKLNFI--GDLSEMTDLRTLNLRYNRISSIKT----NA 996

  Fly   430 PGLKGLDLAQNQFARVDSQLLAGLPSLRRLDLSENGLIELAPNSFRHNPLLETLNISSNELTKIH 494
            ..|:.|.|..|:.:..:..    ||.||.|::.||.:..::...| :...:.:|.::..:|:.|.
Yeast   997 SNLQNLFLTDNRISNFEDT----LPKLRALEIQENPITSISFKDF-YPKNMTSLTLNKAQLSSIP 1056

  Fly   495 SSTLIHLERLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQN 559
            ...|..|.                     .:|::.|..|.:|.||...||   |..|..|.:::|
Yeast  1057 GELLTKLS---------------------FLEKLELNQNNLTRLPQEISK---LTKLVFLSVARN 1097

  Fly   560 RIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEADERALLPLAELR 624
            ::|.:|....| ...||.|.|..|.:|...|    |::.|                      ||.
Yeast  1098 KLEYIPPELSQ-LKSLRTLDLHSNNIRDFVD----GMENL----------------------ELT 1135

  Fly   625 NLNLQSNKL--EAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISVG 687
            :||:.||..  .::.::|:.|.|...:|                 .:||.:...:.|...|....
Yeast  1136 SLNISSNAFGNSSLENSFYHNMSYGSKL-----------------SKSLMFFIAADNQFDDAMWP 1183

  Fly   688 LGN-LNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLSNNLIVELQQGTFRNLPKLQYLDLSSNE 751
            |.| ..||:.::||||..|.:....:   .::.|:.||.|.:..|...|......|:.|.|:||:
Yeast  1184 LFNCFVNLKVLNLSYNNFSDVSHMKL---ESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQ 1245

  Fly   752 IRNVEPGALKGLDELQEFVLADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVF 816
            :.:: |..|..|.:|..|.:..|:|                   :||...|....::.|...|.:
Yeast  1246 MLSL-PAELSNLSQLSVFDVGANQL-------------------KYNISNYHYDWNWRNNKELKY 1290

  Fly   817 LNLSNNHFRNMENIGLRSMRNLEV-LDLSTNGVKLVSTMP-LKALNWLVELKMDNNQICRIQGSP 879
            ||.|.|  |..|   ::|..:.:: .|||.     ::.:| ||.|. |:::.::..::      |
Yeast  1291 LNFSGN--RRFE---IKSFISHDIDADLSD-----LTVLPQLKVLG-LMDVTLNTTKV------P 1338

  Fly   880 FETMP-RLRVLSMRNNQLR-------------SIKERTFRNVRGN 910
            .|.:. |||..:...|.:|             |.::.||...|||
Yeast  1339 DENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGN 1383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380 3/12 (25%)
LRR_8 183..244 CDD:290566 11/61 (18%)
leucine-rich repeat 185..209 CDD:275380 3/24 (13%)
LRR_4 209..247 CDD:289563 9/37 (24%)
leucine-rich repeat 210..233 CDD:275380 5/22 (23%)
leucine-rich repeat 234..259 CDD:275380 6/24 (25%)
LRR_RI 250..492 CDD:238064 58/241 (24%)
LRR_8 259..318 CDD:290566 18/58 (31%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
leucine-rich repeat 284..307 CDD:275380 7/22 (32%)
leucine-rich repeat 308..359 CDD:275380 5/50 (10%)
leucine-rich repeat 334..348 CDD:275378 0/13 (0%)
LRR_8 358..418 CDD:290566 19/59 (32%)
leucine-rich repeat 360..383 CDD:275380 6/22 (27%)
leucine-rich repeat 384..407 CDD:275380 8/22 (36%)
LRR_8 406..466 CDD:290566 19/59 (32%)
leucine-rich repeat 408..431 CDD:275380 8/22 (36%)
leucine-rich repeat 432..455 CDD:275380 5/22 (23%)
LRR_RI 447..705 CDD:238064 59/260 (23%)
LRR_8 454..514 CDD:290566 12/59 (20%)
leucine-rich repeat 456..476 CDD:275380 6/19 (32%)
leucine-rich repeat 480..501 CDD:275380 4/20 (20%)
leucine-rich repeat 505..517 CDD:275378 0/11 (0%)
leucine-rich repeat 525..550 CDD:275380 9/24 (38%)
LRR_8 549..609 CDD:290566 15/59 (25%)
leucine-rich repeat 551..574 CDD:275380 6/22 (27%)
leucine-rich repeat 575..598 CDD:275380 8/22 (36%)
leucine-rich repeat 599..622 CDD:275380 1/22 (5%)
LRR_8 622..681 CDD:290566 13/60 (22%)
leucine-rich repeat 623..646 CDD:275380 7/24 (29%)
LRR_RI 647..896 CDD:238064 58/252 (23%)
leucine-rich repeat 647..670 CDD:275380 1/22 (5%)
leucine-rich repeat 671..693 CDD:275380 5/22 (23%)
leucine-rich repeat 694..717 CDD:275380 6/22 (27%)
LRR_8 716..776 CDD:290566 17/59 (29%)
leucine-rich repeat 718..741 CDD:275380 6/22 (27%)
leucine-rich repeat 742..763 CDD:275380 7/20 (35%)
LRR_8 765..824 CDD:290566 13/58 (22%)
leucine-rich repeat 766..789 CDD:275380 4/22 (18%)
leucine-rich repeat 790..813 CDD:275380 4/22 (18%)
leucine-rich repeat 814..835 CDD:275380 7/20 (35%)
leucine-rich repeat 838..861 CDD:275380 7/24 (29%)
LRR_8 862..921 CDD:290566 14/63 (22%)
leucine-rich repeat 862..885 CDD:275380 3/23 (13%)
leucine-rich repeat 886..906 CDD:275380 7/32 (22%)
TPKR_C2 919..>946 CDD:301599
CYR1NP_012529.3 Ad_cyc_g-alpha 368..418 CDD:369912
RA_PHLPP_like 678..776 CDD:340473
PLN00113 792..>1273 CDD:215061 139/617 (23%)
leucine-rich repeat 796..817 CDD:275380 3/20 (15%)
leucine-rich repeat 818..839 CDD:275380 5/20 (25%)
leucine-rich repeat 840..864 CDD:275380 6/25 (24%)
leucine-rich repeat 865..887 CDD:275380 7/22 (32%)
leucine-rich repeat 888..910 CDD:275380 7/22 (32%)
leucine-rich repeat 911..933 CDD:275380 5/50 (10%)
leucine-rich repeat 934..956 CDD:275380 6/22 (27%)
leucine-rich repeat 957..978 CDD:275380 8/22 (36%)
leucine-rich repeat 979..1018 CDD:275380 13/46 (28%)
leucine-rich repeat 1019..1041 CDD:275380 6/22 (27%)
leucine-rich repeat 1042..1065 CDD:275380 5/43 (12%)
leucine-rich repeat 1066..1088 CDD:275380 9/24 (38%)
leucine-rich repeat 1089..1111 CDD:275380 6/22 (27%)
leucine-rich repeat 1167..1187 CDD:275380 4/19 (21%)
leucine-rich repeat 1191..1211 CDD:275380 6/22 (27%)
leucine-rich repeat 1236..1258 CDD:275380 8/22 (36%)
leucine-rich repeat 1259..1287 CDD:275380 8/46 (17%)
PP2C 1374..1617 CDD:395385 5/10 (50%)
CYCc 1613..1825 CDD:214485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.870

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