DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and Lrrc15

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_083249.1 Gene:Lrrc15 / 74488 MGIID:1921738 Length:579 Species:Mus musculus


Alignment Length:558 Identity:149/558 - (26%)
Similarity:233/558 - (41%) Gaps:75/558 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   503 RLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRH 567
            |..:|:.:..|:.::.:.||.....:.:....||.||  ..|.|.:..|..|.:.:|.:..:...
Mouse    33 RASQVECTGAQIVAMPSPLPWNAMSLQILNTHITELP--EDKFLNISALIALKMEKNELANIMPG 95

  Fly   568 GFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNK 632
            .|:....||.||||.|:|:.|....|..:..||.|.|..|||.:.........:.|:.|.|..|.
Mouse    96 AFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNN 160

  Fly   633 LEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISVG-LGNLNNLRD 696
            ||.|.:..|.:...|.:|:|..|....:||..|....:|:.|.|..|.|.||.:| ...|.||::
Mouse   161 LEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLSDIPMGTFDALGNLQE 225

  Fly   697 IDLSYNQISRIQSDVIGGWRNVVEIRLSNNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALK 761
            :.|..|||..:...:....||:..:.||||.|..|..|.|..||.|..|.|..|.::.:.||...
Mouse   226 LALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFGNSLKELSPGVFG 290

  Fly   762 GLDELQEFVLADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRN 826
            .:..|:|..|.:|.:..|.|:.|..|..|......:|:|.||||.:|:...:|..|:|..|..::
Mouse   291 PMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNLRELSLHTNALQD 355

  Fly   827 MENIGLRSMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSM 891
            ::....||:.||.                        .:.:.||::.::.||.|..:..|..:.:
Mouse   356 LDGNVFRSLANLR------------------------NVSLQNNRLRQLPGSIFANVNGLMTIQL 396

  Fly   892 RNNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFPYPGPKCQDGRLLRSAR 956
            :||.|.::....|.:: ||:..|.:..||..|:..:..|..||                :|..||
Mouse   397 QNNNLENLPLGIFDHL-GNLCELRLYDNPWRCDSNILPLHDWL----------------ILNRAR 444

  Fly   957 MERSLCVGADIYGNERTDGNQLPLLNEHGDVFQRDLPDDFNDECEAGEGTRLPGDRPLV-GESEY 1020
            :      |.|          .||:.:....|..:.|         .......||  |.| |....
Mouse   445 L------GTD----------TLPVCSSPASVRGQSL---------VIINVNFPG--PSVQGPETP 482

  Fly  1021 FYDQYVDATEAPDTTHSAISTSQRPKPTPTINSNIDLN 1058
            ....|.|.:..||:| |..||::..:.|.  :...|||
Mouse   483 EVSSYPDTSSYPDST-SISSTTEITRSTD--DDYTDLN 517

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
LRR_8 183..244 CDD:290566
leucine-rich repeat 185..209 CDD:275380
LRR_4 209..247 CDD:289563
leucine-rich repeat 210..233 CDD:275380
leucine-rich repeat 234..259 CDD:275380
LRR_RI 250..492 CDD:238064
LRR_8 259..318 CDD:290566
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..359 CDD:275380
leucine-rich repeat 334..348 CDD:275378
LRR_8 358..418 CDD:290566
leucine-rich repeat 360..383 CDD:275380
leucine-rich repeat 384..407 CDD:275380
LRR_8 406..466 CDD:290566
leucine-rich repeat 408..431 CDD:275380
leucine-rich repeat 432..455 CDD:275380
LRR_RI 447..705 CDD:238064 61/202 (30%)
LRR_8 454..514 CDD:290566 2/10 (20%)
leucine-rich repeat 456..476 CDD:275380
leucine-rich repeat 480..501 CDD:275380
leucine-rich repeat 505..517 CDD:275378 2/11 (18%)
leucine-rich repeat 525..550 CDD:275380 6/24 (25%)
LRR_8 549..609 CDD:290566 19/59 (32%)
leucine-rich repeat 551..574 CDD:275380 4/22 (18%)
leucine-rich repeat 575..598 CDD:275380 10/22 (45%)
leucine-rich repeat 599..622 CDD:275380 7/22 (32%)
LRR_8 622..681 CDD:290566 19/58 (33%)
leucine-rich repeat 623..646 CDD:275380 8/22 (36%)
LRR_RI 647..896 CDD:238064 72/249 (29%)
leucine-rich repeat 647..670 CDD:275380 7/22 (32%)
leucine-rich repeat 671..693 CDD:275380 9/22 (41%)
leucine-rich repeat 694..717 CDD:275380 5/22 (23%)
LRR_8 716..776 CDD:290566 22/59 (37%)
leucine-rich repeat 718..741 CDD:275380 9/22 (41%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
LRR_8 765..824 CDD:290566 20/58 (34%)
leucine-rich repeat 766..789 CDD:275380 8/22 (36%)
leucine-rich repeat 790..813 CDD:275380 8/22 (36%)
leucine-rich repeat 814..835 CDD:275380 5/20 (25%)
leucine-rich repeat 838..861 CDD:275380 1/22 (5%)
LRR_8 862..921 CDD:290566 14/58 (24%)
leucine-rich repeat 862..885 CDD:275380 5/22 (23%)
leucine-rich repeat 886..906 CDD:275380 5/19 (26%)
TPKR_C2 919..>946 CDD:301599 6/26 (23%)
Lrrc15NP_083249.1 LRR 1 54..75 5/22 (23%)
leucine-rich repeat 58..78 CDD:275380 6/21 (29%)
LRR 2 78..99 4/20 (20%)
PLN00113 82..>401 CDD:215061 100/342 (29%)
LRR 3 102..123 10/20 (50%)
leucine-rich repeat 103..126 CDD:275380 10/22 (45%)
LRR 4 126..147 7/20 (35%)
leucine-rich repeat 127..150 CDD:275380 7/22 (32%)
LRR 5 150..171 8/20 (40%)
leucine-rich repeat 151..174 CDD:275380 8/22 (36%)
LRR 6 174..195 7/20 (35%)
leucine-rich repeat 175..198 CDD:275380 7/22 (32%)
LRR 7 198..219 8/20 (40%)
leucine-rich repeat 199..222 CDD:275380 9/22 (41%)
LRR 8 222..243 6/20 (30%)
leucine-rich repeat 223..246 CDD:275380 5/22 (23%)
LRR 9 246..267 9/20 (45%)
leucine-rich repeat 247..270 CDD:275380 9/22 (41%)
LRR 10 270..291 6/20 (30%)
leucine-rich repeat 271..294 CDD:275380 6/22 (27%)
LRR 11 294..315 7/20 (35%)
leucine-rich repeat 295..318 CDD:275380 8/22 (36%)
LRR 12 318..339 8/20 (40%)
leucine-rich repeat 319..342 CDD:275380 8/22 (36%)
LRR 13 342..363 4/20 (20%)
leucine-rich repeat 343..364 CDD:275380 5/20 (25%)
LRR 14 366..387 7/44 (16%)
leucine-rich repeat 367..387 CDD:275380 6/43 (14%)
LRR 15 390..411 5/20 (25%)
leucine-rich repeat 391..412 CDD:275380 5/20 (25%)
LRRCT 423..>462 CDD:214507 14/70 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..509 10/33 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42484
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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