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Protein Alignment atk and TLR5

DIOPT Version :10

Sequence 1:	NP_649228.1	Gene:	atk / 40266	FlyBaseID:	FBgn0036995	Length:	1535	Species:	Drosophila melanogaster
Sequence 2:	NP_003259.2	Gene:	TLR5 / 7100	HGNCID:	11851	Length:	858	Species:	Homo sapiens

Alignment Length:	756	Identity:	184/756 - (24%)
Similarity:	283/756 - (37%)	Gaps:	203/756 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LDNNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQL----KTIYLQNNLIRRIHPES 325
            ||..|..|:..|....:|:.|    .|.||...::....:.||:    :.:.|..|.||.:...|
Human     5 LDLLLGVVLMAGPVFGIPSCS----FDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASS 65

  Fly   326 L-----LQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGTLE 385
            .     ||.    :|....|.......||.|    .||.||.||:..:.:..|...|.:|...|.
Human    66 FPFLEQLQL----LELGSQYTPLTIDKEAFR----NLPNLRILDLGSSKIYFLHPDAFQGLFHLF 122

  Fly   386 QLHLNHNHLRLIERDALMA------MPALRELRMRNNSLSSDLPLP-FWNLPGLKGLDLAQNQFA 443
            :|.|....|    .||::.      :.||..|.:..|.:.|....| |..|..||.:|.:.||..
Human   123 ELRLYFCGL----SDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIF 183

  Fly   444 RVDSQLLAGL--PSLRRLDLSENGLIELAP-------NSFRHNPLLETLNIS------------S 487
            .|....|..|  .:|....|:.|.|.....       |.|| |.:||.|::|            |
Human   184 LVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFR-NMVLEILDVSGNGWTVDITGNFS 247

  Fly   488 NELTKIHSSTLIHLERLFEVDASYNQLK----SVIAGLPRIVERISLKGNQITSLPAAASKDLQL 548
            |.::|..:.:||....:......::.:|    :..|||.|
Human   248 NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR------------------------- 287

  Fly   549 PNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEAD 613
            .::|.||||...:..|....|:...:|:||:||.|::.::.|.:|.|:..|::|:|..|.|||..
Human   288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352

  Fly   614 ERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRSIS--PTAFDTQRSLEYLDL 676
            ......|.::..::||.|.:..|.|..|....:|:.|||..|.:.:|.  |       |:..:.|
Human   353 SSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP-------SIPDIFL 410

  Fly   677 SGNALLDISVGLGNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLSNNLIVELQQGTFRNLPK 741
            |||.|:          .|..|:|:.|.|            ::.|.||.|..|:..    ...:|.
Human   411 SGNKLV----------TLPKINLTANLI------------HLSENRLENLDILYF----LLRVPH 449

  Fly   742 LQYLDLSSNEIRNVE----PGALKGLDELQEFVLADNKL-----VELKDHVFEELPSLLASHFQY 797
            ||.|.|:.|...:..    |.....|::|   .|.:|.|     .||...|||.|..|...:..:
Human   450 LQILILNQNRFSSCSGDQTPSENPSLEQL---FLGENMLQLAWETELCWDVFEGLSHLQVLYLNH 511

  Fly   798 NKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLRSMRNLEVLDLSTNGVKLVSTMPLKALNWL 862
            |.|..:.|..|.:..:|..|:|::|....:.:..|.:  |||:||:|.|  :|::..|
Human   512 NYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILDISRN--QLLAPNP------- 565

  Fly   863 VELKMDNNQICRIQGSPFETMPRLRVLSMRNNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEM 927
                                                       :|..::::||:..|...|.||:
Human   566 -------------------------------------------DVFVSLSVLDITHNKFICECEL 587

  Fly   928 QWLSVWLQETNFPYPGPKCQDGRLLRSARMERSLCVGADIY 968
            .....||..||....||.                   ||||
Human   588 STFINWLNHTNVTIAGPP-------------------ADIY 609

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.