DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and TLR3

DIOPT Version :10

Sequence 1:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens


Alignment Length:767 Identity:188/767 - (24%)
Similarity:314/767 - (40%) Gaps:190/767 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 LDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVGRIVKDLEHLKKLRLDNNLITVIEDGS 277
            |:|:||.|..:.....:|...|.||.:..|.||.  :...:.:.|..||.|.|.:|.::.:.|.:
Human    56 LNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISK--LEPELCQKLPMLKVLNLQHNELSQLSDKT 118

  Fly   278 FVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLIRRIHPESLLQASGSGVEAVHMYNN 342
            |....||:||||..|.|.:::...|::         |.|||.                       
Human   119 FAFCTNLTELHLMSNSIQKIKNNPFVK---------QKNLIT----------------------- 151

  Fly   343 EIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDAL--MAM 405
                                ||:|.|.||....|.......|::|.|::|.::.::.:.|  .|.
Human   152 --------------------LDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN 196

  Fly   406 PALRELRMRNNSLSSDLPLPFWNLPGLKGLDLAQNQFARVDSQLLAGLPSLRRLDLSENGLIELA 470
            .:|::|.:.:|.:....|..|..:..|.||.|...|..          ||     |:|...:|||
Human   197 SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLG----------PS-----LTEKLCLELA 246

  Fly   471 PNSFRHNPLLETLNISSNELTKIHSSTLIHLE--RLFEVDASYNQLKSVIAGLPRIVERISLKGN 533
            ..|.|:      |::|:::|:...::|.:.|:  .|..:|.|||.|..|              ||
Human   247 NTSIRN------LSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVV--------------GN 291

  Fly   534 QITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQN---------ELRQLK 589
            ...:         .||.|....|..|.|:.|..|...|...:|.|:|.::         .|.::.
Human   292 DSFA---------WLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKID 347

  Fly   590 DTSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSN--KLEAITDNFFSN--NSRLEQL 650
            |.||..::.||.|::::|.:..........|..|:.|:|.::  .|..:|:..|.:  :|.|..|
Human   348 DFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHIL 412

  Fly   651 DLSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISVGLGNLNNLRDIDLSYNQISRIQSDVIG-G 714
            :|::|.|..|...||.....||.|||.                          ::.|..::.| .
Human   413 NLTKNKISKIESDAFSWLGHLEVLDLG--------------------------LNEIGQELTGQE 451

  Fly   715 WR---NVVEIRLSNNLIVELQQGTFRNLPKLQYLDLSSNEIRNVE--PGALKGLDELQEFVLADN 774
            ||   |:.||.||.|..::|.:.:|..:|.||.|.|....::||:  |...:.|..|....|::|
Human   452 WRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNN 516

  Fly   775 KLVELKDHVFEELPSLLASHFQYNKL----RYISPESFHNANSLVFL-NLSNNHFRNMENIG--- 831
            .:..:.|.:.|.|..|.....|:|.|    ::.:|     ...:.|| .||:.|..|:|:.|   
Human   517 NIANINDDMLEGLEKLEILDLQHNNLARLWKHANP-----GGPIYFLKGLSHLHILNLESNGFDE 576

  Fly   832 -----LRSMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSM 891
                 .:.:..|:::||..|.   ::|:|....         |||:            .|:.|::
Human   577 IPVEVFKDLFELKIIDLGLNN---LNTLPASVF---------NNQV------------SLKSLNL 617

  Fly   892 RNNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCE-MQWLSVWLQETNFPYP 942
            :.|.:.|::::.|.....|:..||:..||.||.|| :.|...|:.||:...|
Human   618 QKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIP 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380 5/19 (26%)
PCC 891..>936 CDD:188093 14/45 (31%)
leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
LRR 93..530 CDD:443914 77/320 (24%)
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
leucine-rich repeat 185..209 CDD:275380
leucine-rich repeat 210..233 CDD:275380 6/19 (32%)
leucine-rich repeat 234..259 CDD:275380 7/24 (29%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..359 CDD:275380 4/50 (8%)
leucine-rich repeat 334..348 CDD:275378 0/13 (0%)
PLN00113 359..>824 CDD:215061 123/492 (25%)
leucine-rich repeat 360..383 CDD:275380 7/22 (32%)
leucine-rich repeat 384..407 CDD:275380 6/24 (25%)
leucine-rich repeat 408..431 CDD:275380 5/22 (23%)
leucine-rich repeat 432..455 CDD:275380 5/22 (23%)
leucine-rich repeat 456..476 CDD:275380 6/19 (32%)
leucine-rich repeat 480..501 CDD:275380 4/20 (20%)
leucine-rich repeat 505..517 CDD:275378 5/11 (45%)
leucine-rich repeat 525..550 CDD:275380 3/24 (13%)
leucine-rich repeat 551..574 CDD:275380 7/22 (32%)
leucine-rich repeat 575..598 CDD:275380 7/31 (23%)
leucine-rich repeat 599..622 CDD:275380 5/22 (23%)
leucine-rich repeat 623..646 CDD:275380 6/26 (23%)
leucine-rich repeat 647..670 CDD:275380 8/22 (36%)
leucine-rich repeat 671..693 CDD:275380 5/21 (24%)
leucine-rich repeat 694..717 CDD:275380 4/26 (15%)
leucine-rich repeat 718..741 CDD:275380 7/22 (32%)
leucine-rich repeat 742..763 CDD:275380 7/22 (32%)
leucine-rich repeat 766..789 CDD:275380 6/22 (27%)
leucine-rich repeat 790..813 CDD:275380 5/26 (19%)
leucine-rich repeat 814..835 CDD:275380 8/29 (28%)
leucine-rich repeat 838..861 CDD:275380 6/22 (27%)
leucine-rich repeat 862..885 CDD:275380 3/22 (14%)
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380
LRR <36..309 CDD:443914 83/350 (24%)
LRR 1 52..73 5/16 (31%)
leucine-rich repeat 53..76 CDD:275380 6/19 (32%)
LRR 2 76..97 6/22 (27%)
leucine-rich repeat 77..100 CDD:275380 7/24 (29%)
LRR 3 100..121 7/20 (35%)
leucine-rich repeat 101..124 CDD:275380 7/22 (32%)
LRR 4 124..145 9/20 (45%)
leucine-rich repeat 125..148 CDD:275380 9/31 (29%)
LRR 5 148..168 10/62 (16%)
leucine-rich repeat 149..198 CDD:275380 15/91 (16%)
LRR 6 172..193 5/20 (25%)
LRR 7 198..219 5/20 (25%)
leucine-rich repeat 199..249 CDD:275380 17/64 (27%)
LRR 8 222..244 9/36 (25%)
LRR 9 249..270 6/26 (23%)
leucine-rich repeat 250..275 CDD:275380 6/30 (20%)
LRR 10 275..296 9/43 (21%)
leucine-rich repeat 276..299 CDD:275380 10/45 (22%)
LRR 284..>630 CDD:443914 99/423 (23%)
LRR 11 299..320 6/20 (30%)
leucine-rich repeat 300..321 CDD:275380 6/20 (30%)
LRR 12 323..344 3/20 (15%)
LRR 13 356..377 4/20 (20%)
leucine-rich repeat 357..380 CDD:275380 5/22 (23%)
LRR 14 380..400 5/19 (26%)
leucine-rich repeat 381..406 CDD:275380 6/24 (25%)
LRR 15 408..429 8/20 (40%)
leucine-rich repeat 409..432 CDD:275380 8/22 (36%)
LRR 16 432..454 8/47 (17%)
leucine-rich repeat 433..457 CDD:275380 9/49 (18%)
leucine-rich repeat 458..481 CDD:275380 7/22 (32%)
LRR 17 465..486 6/20 (30%)
leucine-rich repeat 482..507 CDD:275380 8/24 (33%)
LRR 18 507..528 4/20 (20%)
leucine-rich repeat 508..531 CDD:275380 6/22 (27%)
LRR 19 531..552 5/25 (20%)
leucine-rich repeat 532..563 CDD:275380 8/35 (23%)
LRR 20 563..584 4/20 (20%)
leucine-rich repeat 564..585 CDD:275380 4/20 (20%)
LRR 21 587..608 6/32 (19%)
leucine-rich repeat 588..611 CDD:275380 9/46 (20%)
LRR 22 611..632 5/20 (25%)
leucine-rich repeat 612..630 CDD:275380 4/17 (24%)
leucine-rich repeat 637..659 CDD:275380 9/21 (43%)
LRRCT 645..697 CDD:214507 11/25 (44%)
Tlr3_TMD 698..730 CDD:465595
TIR 755..900 CDD:214587
Blue background indicates that the domain is not in the aligned region.

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