DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and LRRC7

DIOPT Version :10

Sequence 1:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_001357714.1 Gene:LRRC7 / 57554 HGNCID:18531 Length:1575 Species:Homo sapiens


Alignment Length:1736 Identity:345/1736 - (19%)
Similarity:564/1736 - (32%) Gaps:602/1736 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 NLIRAESCPPSQAILPC---RCSLRGK-EIQIWCSHSNLPQIMDGLKAVERNIKGRIDELVLENN 75
            ||||..: ||.....||   |.:||.: |.::.|..          ...:|.|.||:        
Human     4 NLIRGRN-PPQYQRSPCKEVRAALRKRPEEELQCLE----------MTTKRKIIGRL-------- 49

  Fly    76 QLPALPGRFF-GSLQIVRLM-LRHNSIERVSNGWLNELENGLVEIFVVEPQLRSIPAESLNGMIN 138
                :|.|.| |..:|:.:: ..|.|:::|.....| .|..|.|:::...|:..:|.:..|    
Human    50 ----VPCRCFRGEEEIISVLDYSHCSLQQVPKEVFN-FERTLEELYLDANQIEELPKQLFN---- 105

  Fly   139 MLAITIQSEELKHLPDFSGLLSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGGSGLTRLEAGL 203
                               ..:|..||:....|..||:.:                         
Human   106 -------------------CQALRKLSIPDNDLSNLPTTI------------------------- 126

  Fly   204 FDGLISLKNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVGRIVKDLEHLKKLRLDNN 268
             ..|::||.||:|.||:.                :...|           :|..:.|..:....|
Human   127 -ASLVNLKELDISKNGVQ----------------EFPEN-----------IKCCKCLTIIEASVN 163

  Fly   269 LITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLIRRIHPESLLQASGSG 333
            .|:.:.|| |..|.||::|:||| ...|.....|.|..:|:.:.|:.|                 
Human   164 PISKLPDG-FTQLLNLTQLYLND-AFLEFLPANFGRLVKLRILELREN----------------- 209

  Fly   334 VEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGTLEQLHLNHNHLRLIE 398
                        |::.|...:..|.:|..||:..|...|||                        
Human   210 ------------HLKTLPKSMHKLAQLERLDLGNNEFGELP------------------------ 238

  Fly   399 RDALMAMPALRELRMRNNSLSSDLPLPFWNLPGLKGLDLAQNQFARVDSQLLAGLPSLRRLDLSE 463
             :.|..:..||||.|.||:|.. ||.....|..|..||:::|:...||.. ::|..:|..|.||.
Human   239 -EVLDQIQNLRELWMDNNALQV-LPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEALEDLLLSS 300

  Fly   464 NGLIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHLERLFEVDASYNQLKSV--IAGLPRIVE 526
            |.|.:| |:|......|.||.:..|:||.: .:|:.:|..|.|.|.|.|:|:|:  ..|....:.
Human   301 NMLQQL-PDSIGLLKKLTTLKVDDNQLTML-PNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 363

  Fly   527 RISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAME-LRVLSLAQNELRQLKD 590
            .:::..|.:..||....   ...|:.::.|..|::|.||..  .|.|: ||||:|:.|.|:.| .
Human   364 TLAVDENFLPELPREIG---SCKNVTVMSLRSNKLEFLPEE--IGQMQKLRVLNLSDNRLKNL-P 422

  Fly   591 TSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRN 655
            .||..::.|..|.|.:||     .:||:||....:   ...|...:|:..|....|.:: |...:
Human   423 FSFTKLKELAALWLSDNQ-----SKALIPLQTEAH---PETKQRVLTNYMFPQQPRGDE-DFQSD 478

  Fly   656 LIRSISPTAFDTQR------SLEYLDL-----SGNALLDISVGLGNLNNLRDIDLSYNQISRIQS 709
             ..|.:||.::.||      :.|:.|.     :...:.|:|.........|.|.|   |.:|:..
Human   479 -SDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITL---QPARLSG 539

  Fly   710 DVIGGWRNVVEIRLSNNLIVELQQGTF-RNLPKLQYLDLSSNEIRNVEPGALKGLDELQEF---- 769
            |....|....:         ::|.... :|.|:|.:             |.:.||.:.:..    
Human   540 DCCTPWARCDQ---------QIQDMPVPQNDPQLAW-------------GCISGLQQERSMCTPL 582

  Fly   770 -VLADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLR 833
             |.|.:          ..||||.....:.|..||.:|                 :..:::|: ::
Human   583 PVAAQS----------TTLPSLSGRQVEINLKRYPTP-----------------YPEDLKNM-VK 619

  Fly   834 SMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNN---------------------QICRIQG 877
            |::||  :...::||::.::.|.......|:.|.::.                     :|..:..
Human   620 SVQNL--VGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHP 682

  Fly   878 SPFET---MPRLRVLSMRNNQL-------------RSIKERTF------------RNVRGNIAIL 914
            |..||   .|:|.:|.....:.             .|:...|:            .|.|..:..|
Human   683 SLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSL 747

  Fly   915 DVDGNPIDCNCEMQWLSVWLQE--TNFPYPGPKCQDGRLLRSARMERSLCVG-----------AD 966
            .........|      |:|...  .:||.|    .|.:.|.|.|  .::..|           :|
Human   748 QTTAKDAVHN------SLWGNRIAPSFPQP----LDSKPLLSQR--EAVPPGNIPQRPDRLPMSD 800

  Fly   967 IYGNERTDGNQLPLLNEHGDVFQRDLPDDFNDE---CEAGEGTRLPGDRPLVG---------ESE 1019
            .:.:..|||:.   .:..|.|.:....::.|..   ......|...|.|||:.         |.|
Human   801 TFTDNWTDGSH---YDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELE 862

  Fly  1020 YFYDQYVDATEAP----------------DTT--HSAISTSQRPKPTPTINSNIDLNNTI----- 1061
            ....::...||.|                |.|  .|.:.|:....|.|....:|..:..|     
Human   863 QSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFS 927

  Fly  1062 ------LHTKYFNR-----------KPQPGSG-----------SP-------------------- 1078
                  .|....||           :|:...|           ||                    
Human   928 PGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEID 992

  Fly  1079 ---FTFFGYPL---------------PSVSLGRFFGFGDRGRKQRTDSNDDMPATHRMAHISLPS 1125
               :..:..||               |...||...|.....|.|.....||...|:         
Human   993 IGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTY--------- 1048

  Fly  1126 GRGKTRMYQPNSAEFEKYLKDQQ--------------------------KQEKLNIARN------ 1158
            |..|....|..|...:.|..||.                          :|...|||::      
Human  1049 GSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRA 1113

  Fly  1159 -------RYVDTDSTTSSMEDALSN-ESGSAATTVGVFRTTFREPSSIERGGFRPIVPAHVGGFM 1215
                   ..:.:.|..|..|||:.| :..|.....|..|......|:.|...||.:...|.   :
Human  1114 YRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHE---L 1175

  Fly  1216 PVHD----PQQRRGLVEVVNITGNPSEIVQGIGQRK-----FIPISTQARPKPTKS-------SG 1264
            |..|    |..|.||....::|...|:.::..|:.:     :..:..||...|.|:       |.
Human  1176 PPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSA 1240

  Fly  1265 ESSETATYEVTETTPDIT--TTTPLMQRIATSTTKASTTTTRSTTTTSTTQVTPAENNAS----- 1322
            .|..|.:|..::|.|...  |...|:::|.:.....:.....|..:...|:.||.:...|     
Human  1241 RSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMP 1305

  Fly  1323 -----------SSTELD------------------------------------SQYDDEDLEAQS 1340
                       .:..||                                    |::|.::|    
Human  1306 ADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQEL---- 1366

  Fly  1341 VTLLRPPPLVQTTTAETILL----------------------IPP------AEEHVAQIK-SRSW 1376
                   ||.:|.:.::.:|                      :||      |..|:..:. |:|.
Human  1367 -------PLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSL 1424

  Fly  1377 VTTTTPQSPSD---NQVTLAGPTSTVPPPPPASPPLRG--GGRSTI 1417
            ...:..|.|.:   |:||:....|.:|...|:|...||  .||..|
Human  1425 QHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLI 1470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380 4/44 (9%)
PCC 891..>936 CDD:188093 8/69 (12%)
leucine-rich repeat 69..89 CDD:275380 4/20 (20%)
leucine-rich repeat 90..113 CDD:275380 5/23 (22%)
LRR 93..530 CDD:443914 99/439 (23%)
leucine-rich repeat 115..138 CDD:275380 5/22 (23%)
leucine-rich repeat 139..160 CDD:275380 0/20 (0%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 185..209 CDD:275380 1/23 (4%)
leucine-rich repeat 210..233 CDD:275380 7/22 (32%)
leucine-rich repeat 234..259 CDD:275380 2/24 (8%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..359 CDD:275380 6/50 (12%)
leucine-rich repeat 334..348 CDD:275378 1/13 (8%)
PLN00113 359..>824 CDD:215061 119/484 (25%)
leucine-rich repeat 360..383 CDD:275380 7/22 (32%)
leucine-rich repeat 384..407 CDD:275380 1/22 (5%)
leucine-rich repeat 408..431 CDD:275380 11/22 (50%)
leucine-rich repeat 432..455 CDD:275380 7/22 (32%)
leucine-rich repeat 456..476 CDD:275380 9/19 (47%)
leucine-rich repeat 480..501 CDD:275380 7/20 (35%)
leucine-rich repeat 505..517 CDD:275378 5/11 (45%)
leucine-rich repeat 525..550 CDD:275380 3/24 (13%)
leucine-rich repeat 551..574 CDD:275380 6/22 (27%)
leucine-rich repeat 575..598 CDD:275380 10/22 (45%)
leucine-rich repeat 599..622 CDD:275380 9/22 (41%)
leucine-rich repeat 623..646 CDD:275380 3/22 (14%)
leucine-rich repeat 647..670 CDD:275380 6/28 (21%)
leucine-rich repeat 671..693 CDD:275380 4/26 (15%)
leucine-rich repeat 694..717 CDD:275380 7/22 (32%)
leucine-rich repeat 718..741 CDD:275380 2/23 (9%)
leucine-rich repeat 742..763 CDD:275380 2/20 (10%)
leucine-rich repeat 766..789 CDD:275380 3/27 (11%)
leucine-rich repeat 790..813 CDD:275380 5/22 (23%)
leucine-rich repeat 814..835 CDD:275380 1/20 (5%)
leucine-rich repeat 838..861 CDD:275380 4/22 (18%)
leucine-rich repeat 862..885 CDD:275380 6/46 (13%)
LRRC7NP_001357714.1 PRK15370 <15..>280 CDD:185268 87/420 (21%)
leucine-rich repeat 64..85 CDD:275380 5/21 (24%)
leucine-rich repeat 86..108 CDD:275380 5/44 (11%)
leucine-rich repeat 109..131 CDD:275380 7/47 (15%)
leucine-rich repeat 132..177 CDD:275380 16/72 (22%)
LRR 175..>451 CDD:443914 97/345 (28%)
leucine-rich repeat 178..200 CDD:275380 8/22 (36%)
leucine-rich repeat 201..223 CDD:275380 6/50 (12%)
leucine-rich repeat 224..246 CDD:275380 8/46 (17%)
leucine-rich repeat 247..269 CDD:275380 11/22 (50%)
leucine-rich repeat 270..292 CDD:275380 7/22 (32%)
leucine-rich repeat 316..336 CDD:275380 7/20 (35%)
leucine-rich repeat 339..361 CDD:275380 8/21 (38%)
leucine-rich repeat 362..384 CDD:275380 3/24 (13%)
leucine-rich repeat 385..407 CDD:275380 7/23 (30%)
leucine-rich repeat 408..430 CDD:275380 10/22 (45%)
PDZ_densin_erbin-like 1485..1571 CDD:467231
Blue background indicates that the domain is not in the aligned region.

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