DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and TLR8

DIOPT Version :10

Sequence 1:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1103 Identity:256/1103 - (23%)
Similarity:423/1103 - (38%) Gaps:288/1103 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MLLPIFLLLCIGINLIRAESCPPSQAILPCRCSLRGKEIQIWCSHSNLPQIMDGLKAVERNIKGR 66
            ||..||||:.....|...|:...|   .||....:...:...||:..|.:       |.:.:...
Human    28 MLTCIFLLISGSCELCAEENFSRS---YPCDEKKQNDSVIAECSNRRLQE-------VPQTVGKY 82

  Fly    67 IDELVLENNQLPALPGRFFGSLQ-IVRLMLRHNSIERVSNGWLNELENGLVEIFVVEPQLRSIPA 130
            :.||.|.:|.:..:....|..|| :.::.|.||...:..||......|||           :|..
Human    83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGL-----------NITD 136

  Fly   131 ESLNGMINMLAITIQSEELKHLPDFSGL-LSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGGS 194
            .:...:.|:..:.::..:|..:|  ||| .|||.||:....:..:.......|..|:::::....
Human   137 GAFLNLKNLRELLLEDNQLPQIP--SGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNC 199

  Fly   195 GL------TRLEAGLFDGLISLKNLDLSHNGLNWIHLRALSRLP-NLVSLKLSHNQISDV----- 247
            ..      |.:|.|:|:.|.:|:.|.||.|.|:.:.    .:|| :|..|.||:.||..:     
Human   200 YFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVP----PKLPSSLRKLFLSNTQIKYISEEDF 260

  Fly   248 -GMVGRIVKDLE---------HLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAF 302
             |::...:.||.         ....:..|......|:..:|.:|..|..|:|:...:.::....|
Human   261 KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWF 325

  Fly   303 LRTPQLKTIYLQ-NNLIRRIHPESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMS 366
            ...|.||.:.|: |.|:..|       |||                    |.|..||||..||:|
Human   326 KNMPHLKVLDLEFNYLVGEI-------ASG--------------------AFLTMLPRLEILDLS 363

  Fly   367 GNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRN---NSLSSDLPLPFWN 428
            .|.:.    |:...|     ::::.|..:|:         :||.|.:|.   ..|..|...|...
Human   364 FNYIK----GSYPQH-----INISRNFSKLL---------SLRALHLRGYVFQELREDDFQPLMQ 410

  Fly   429 LPGLKGLDLAQNQFARVDSQLLAGLPSLRRLDLSENGLIELAPNSFRHNPLL-ETLNISSNELTK 492
            ||.|..::|..|...::|.:|.....:|..:.||||          |.:||: :|....:|.   
Human   411 LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSEN----------RISPLVKDTRQSYANS--- 462

  Fly   493 IHSSTLIHLERL----FEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRM 553
              ||...|:.:.    ||.|...|.....   .|.|..:.:..|                   :.
Human   463 --SSFQRHIRKRRSTDFEFDPHSNFYHFT---RPLIKPQCAAYG-------------------KA 503

  Fly   554 LDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQ-LKDTSFIGIQRLELLHLQENQLGEADERAL 617
            ||||.|.|..:..:.|:...::..|:|:.|...| |..|.|..|..::.|.|..|:|...:..||
Human   504 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASAL 568

  Fly   618 LPLAELRNLNLQSN----KLEAITDN--FFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDL 676
            ..|::|..|:|..|    ::..:|.:  |..|.:.|:.|:||.|.|.:::.......:||..|..
Human   569 TELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVF 633

  Fly   677 SGNAL-----------LDISVGLGNLNNLRDIDLSYNQISRIQSDV-IGGWRNVVEIRLSNNLIV 729
            |||.|           :.|..||.||..|   |||.|::..|.::. :....::.|:.:::|::.
Human   634 SGNRLDILWNDDDNRYISIFKGLKNLTRL---DLSLNRLKHIPNEAFLNLPASLTELHINDNMLK 695

  Fly   730 ELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADNKLVELKDHVFEELPSLLASH 794
            .......:..|:|:.|||..|::       |...|.|.:|.              ..|.:||.||
Human   696 FFNWTLLQQFPRLELLDLRGNKL-------LFLTDSLSDFT--------------SSLRTLLLSH 739

  Fly   795 FQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLRSMRNLEVLDLSTNGVKLVSTMPLKAL 859
               |::.:: |..|                       |..:.:|:.||||:|.:|.::.      
Human   740 ---NRISHL-PSGF-----------------------LSEVSSLKHLDLSSNLLKTINK------ 771

  Fly   860 NWLVELKMDNNQICRIQGSPFETMPRLRVLSMRNNQLRSIKERTFRNVRGNIAILDVDGNPIDCN 924
                              |..||                 |..|      .:::|::.|||.:|.
Human   772 ------------------SALET-----------------KTTT------KLSMLELHGNPFECT 795

  Fly   925 CEMQWLSVWLQE-TNFPYP--------GPKCQDGRLLRSARMERSLCVGADI-------YGNERT 973
            |::.....|:.| .|...|        .|..|.|:.:.|  :|.:.|| :|:       :....|
Human   796 CDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVS--LELTTCV-SDVTAVILFFFTFFIT 857

  Fly   974 DGNQLPLLNEHGDVFQRDLPDDFNDECEAGEGTRLPGDRPLVGESEYFYDQYV--DATEAPDT 1034
            ....|..|..|  :|..|:...:| .|.|    ::.|.|.| ..|:.|||.|:  |..:|..|
Human   858 TMVMLAALAHH--LFYWDVWFIYN-VCLA----KVKGYRSL-STSQTFYDAYISYDTKDASVT 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380 2/19 (11%)
PCC 891..>936 CDD:188093 9/44 (20%)
leucine-rich repeat 69..89 CDD:275380 5/19 (26%)
leucine-rich repeat 90..113 CDD:275380 5/22 (23%)
LRR 93..530 CDD:443914 109/468 (23%)
leucine-rich repeat 115..138 CDD:275380 2/22 (9%)
leucine-rich repeat 139..160 CDD:275380 5/21 (24%)
leucine-rich repeat 161..184 CDD:275380 5/22 (23%)
leucine-rich repeat 185..209 CDD:275380 6/29 (21%)
leucine-rich repeat 210..233 CDD:275380 8/23 (35%)
leucine-rich repeat 234..259 CDD:275380 9/39 (23%)
leucine-rich repeat 260..283 CDD:275380 4/22 (18%)
leucine-rich repeat 284..307 CDD:275380 4/22 (18%)
leucine-rich repeat 308..359 CDD:275380 12/51 (24%)
leucine-rich repeat 334..348 CDD:275378 0/13 (0%)
PLN00113 359..>824 CDD:215061 117/491 (24%)
leucine-rich repeat 360..383 CDD:275380 7/22 (32%)
leucine-rich repeat 384..407 CDD:275380 2/22 (9%)
leucine-rich repeat 408..431 CDD:275380 8/25 (32%)
leucine-rich repeat 432..455 CDD:275380 5/22 (23%)
leucine-rich repeat 456..476 CDD:275380 5/19 (26%)
leucine-rich repeat 480..501 CDD:275380 4/21 (19%)
leucine-rich repeat 505..517 CDD:275378 4/11 (36%)
leucine-rich repeat 525..550 CDD:275380 1/24 (4%)
leucine-rich repeat 551..574 CDD:275380 7/22 (32%)
leucine-rich repeat 575..598 CDD:275380 8/23 (35%)
leucine-rich repeat 599..622 CDD:275380 7/22 (32%)
leucine-rich repeat 623..646 CDD:275380 7/28 (25%)
leucine-rich repeat 647..670 CDD:275380 6/22 (27%)
leucine-rich repeat 671..693 CDD:275380 11/32 (34%)
leucine-rich repeat 694..717 CDD:275380 6/23 (26%)
leucine-rich repeat 718..741 CDD:275380 2/22 (9%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
leucine-rich repeat 766..789 CDD:275380 3/22 (14%)
leucine-rich repeat 790..813 CDD:275380 7/22 (32%)
leucine-rich repeat 814..835 CDD:275380 1/20 (5%)
leucine-rich repeat 838..861 CDD:275380 7/22 (32%)
leucine-rich repeat 862..885 CDD:275380 3/22 (14%)
TLR8NP_057694.2 LRR 81..460 CDD:443914 106/450 (24%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
leucine-rich repeat 107..144 CDD:275380 9/47 (19%)
leucine-rich repeat 145..165 CDD:275380 5/21 (24%)
leucine-rich repeat 166..189 CDD:275380 5/22 (23%)
leucine-rich repeat 190..220 CDD:275380 6/29 (21%)
leucine-rich repeat 221..241 CDD:275380 8/23 (35%)
leucine-rich repeat 242..265 CDD:275380 7/22 (32%)
leucine-rich repeat 266..306 CDD:275380 6/39 (15%)
leucine-rich repeat 307..330 CDD:275380 4/22 (18%)
leucine-rich repeat 331..356 CDD:275380 12/51 (24%)
leucine-rich repeat 387..413 CDD:275380 8/25 (32%)
leucine-rich repeat 414..437 CDD:275380 5/22 (23%)
LRR 483..>793 CDD:443914 94/429 (22%)
leucine-rich repeat 504..524 CDD:275380 7/19 (37%)
leucine-rich repeat 525..549 CDD:275380 8/23 (35%)
leucine-rich repeat 550..573 CDD:275380 7/22 (32%)
leucine-rich repeat 574..603 CDD:275380 7/28 (25%)
leucine-rich repeat 604..658 CDD:275380 16/53 (30%)
leucine-rich repeat 659..683 CDD:275380 7/26 (27%)
leucine-rich repeat 684..707 CDD:275380 2/22 (9%)
leucine-rich repeat 708..730 CDD:275380 9/42 (21%)
leucine-rich repeat 732..755 CDD:275380 9/49 (18%)
leucine-rich repeat 756..775 CDD:275380 8/42 (19%)
PCC 760..>847 CDD:188093 28/136 (21%)
TIR 898..1040 CDD:214587 6/15 (40%)

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