DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and TLR7

DIOPT Version :10

Sequence 1:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:1046 Identity:244/1046 - (23%)
Similarity:388/1046 - (37%) Gaps:306/1046 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LLPIFLLLCIGINLIRAESCPPSQAILPCRCSL--RGKEIQIWCSHSNLPQIMDGLKAVERNIKG 65
            :|.:|.::.|. .|:.|...|.:   |||..:|  ....:.:.|:..:|.:|..|:.....|   
Human    12 ILILFNIILIS-KLLGARWFPKT---LPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTN--- 69

  Fly    66 RIDELVLENNQLPAL-PGRFFGSLQIVRLMLRHNSIERVSNGWLNELENGLVEIFVVEPQLRSIP 129
                |.|..|.:|.: |..|.....:|.:..|.|.:                          .||
Human    70 ----LTLTINHIPDISPASFHRLDHLVEIDFRCNCV--------------------------PIP 104

  Fly   130 AESLNGM-INMLAITIQSEELKHLPDFSGLLSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGG 193
            ..|.|.| |..|.|..:|        ||||..|..|.:....|.|:|..|   .|.||       
Human   105 LGSKNNMCIKRLQIKPRS--------FSGLTYLKSLYLDGNQLLEIPQGL---PPSLQ------- 151

  Fly   194 SGLTRLEA-GLF----DGLISLKNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVGRI 253
              |..||| .:|    :.|..|.|:::.:.|.|..:     |.|..||..               
Human   152 --LLSLEANNIFSIRKENLTELANIEILYLGQNCYY-----RNPCYVSYS--------------- 194

  Fly   254 VKDLEHLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLI 318
                               ||..:|::|..|..|.|.||.:|.:   ..:....|..:||.||:|
Human   195 -------------------IEKDAFLNLTKLKVLSLKDNNVTAV---PTVLPSTLTELYLYNNMI 237

  Fly   319 RRIHPESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGN----LLSELPYGALR 379
            .:|..:.              :||              |.:|:.||:|||    ..:..|....:
Human   238 AKIQEDD--------------FNN--------------LNQLQILDLSGNCPRCYNAPFPCAPCK 274

  Fly   380 GHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWNLPGLKGLDLAQNQFAR 444
            .:..|:           |..:|..|:..|:.||:.:|||....|..|.|:..|:.|||:||..|:
Human   275 NNSPLQ-----------IPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAK 328

  Fly   445 V--DSQLLAGLPSLRRLDLSENGLIEL---------APNSFRHNPLLETLNISSNELTKIHSSTL 498
            .  |::.|..||||.:||||.|..:::         |.:|.:...:|........||...:.|.|
Human   329 EIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPL 393

  Fly   499 IHLERLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIE- 562
            .:|:.|..:|...|.:|  ||.|                     |...|...|:::|||.|:|. 
Human   394 HNLQNLEVLDLGTNFIK--IANL---------------------SMFKQFKRLKVIDLSVNKISP 435

  Fly   563 --QLPRHGFQGAMELRVLSLAQNELRQL----------------KDTSFIGIQRL-----ELLHL 604
              .....||.......|.|.....|.||                |:.||:.:...     :.|.|
Human   436 SGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDL 500

  Fly   605 QENQLGEADERALLPLAELRNLNLQSNKL-EAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQ 668
            .:|.:..........|:.|:.|||..|.: :.:..:.|...:.|..||.|.|.:..:..|||:..
Human   501 SKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEEL 565

  Fly   669 RSLEYLDLSGNALLDISVGLGNLNN------------LRDIDLSYNQISRIQSDVIGGWRNVVEI 721
            ..||.||:|.|:....|.|:.::.|            :.|.|:|.:....::|:.:    ..:|.
Human   566 HKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESL----RTLEF 626

  Fly   722 RLSNNLIVELQQG------TFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADNKLVELK 780
            | .|:|.|..::|      .|:||.||:.||:|.|.:..:..|...|:                 
Human   627 R-GNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGM----------------- 673

  Fly   781 DHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLRSMRNLEVLDLST 845
                                    |.:..|      |:|:.|..::.....|:.::|||.||||.
Human   674 ------------------------PPNLKN------LSLAKNGLKSFSWKKLQCLKNLETLDLSH 708

  Fly   846 NGVKLVSTMPLKALNWLVELK---MDNNQICRIQGSPFETMPRLRVLSMRNNQLRSIKERTF-RN 906
            |   .::|:|.:..|....||   :.||||..:.....:...:||.|.:.:|:::.|::.:| .|
Human   709 N---QLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPEN 770

  Fly   907 VRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFPYP---------GPKCQDGRLLRSARMERSLC 962
            |..|:.:|.:..|...|.|:..|...|:..|....|         ||....|:.:          
Human   771 VLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSV---------- 825

  Fly   963 VGADIY 968
            :..|:|
Human   826 ISLDLY 831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380 6/20 (30%)
PCC 891..>936 CDD:188093 12/45 (27%)
leucine-rich repeat 69..89 CDD:275380 6/20 (30%)
leucine-rich repeat 90..113 CDD:275380 3/22 (14%)
LRR 93..530 CDD:443914 111/457 (24%)
leucine-rich repeat 115..138 CDD:275380 5/23 (22%)
leucine-rich repeat 139..160 CDD:275380 7/20 (35%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 185..209 CDD:275380 8/28 (29%)
leucine-rich repeat 210..233 CDD:275380 5/22 (23%)
leucine-rich repeat 234..259 CDD:275380 2/24 (8%)
leucine-rich repeat 260..283 CDD:275380 4/22 (18%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..359 CDD:275380 10/50 (20%)
leucine-rich repeat 334..348 CDD:275378 2/13 (15%)
PLN00113 359..>824 CDD:215061 124/522 (24%)
leucine-rich repeat 360..383 CDD:275380 7/26 (27%)
leucine-rich repeat 384..407 CDD:275380 4/22 (18%)
leucine-rich repeat 408..431 CDD:275380 9/22 (41%)
leucine-rich repeat 432..455 CDD:275380 10/24 (42%)
leucine-rich repeat 456..476 CDD:275380 8/28 (29%)
leucine-rich repeat 480..501 CDD:275380 5/20 (25%)
leucine-rich repeat 505..517 CDD:275378 3/11 (27%)
leucine-rich repeat 525..550 CDD:275380 2/24 (8%)
leucine-rich repeat 551..574 CDD:275380 8/25 (32%)
leucine-rich repeat 575..598 CDD:275380 8/38 (21%)
leucine-rich repeat 599..622 CDD:275380 4/27 (15%)
leucine-rich repeat 623..646 CDD:275380 6/23 (26%)
leucine-rich repeat 647..670 CDD:275380 8/22 (36%)
leucine-rich repeat 671..693 CDD:275380 8/21 (38%)
leucine-rich repeat 694..717 CDD:275380 4/22 (18%)
leucine-rich repeat 718..741 CDD:275380 9/28 (32%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
leucine-rich repeat 766..789 CDD:275380 0/22 (0%)
leucine-rich repeat 790..813 CDD:275380 2/22 (9%)
leucine-rich repeat 814..835 CDD:275380 4/20 (20%)
leucine-rich repeat 838..861 CDD:275380 9/22 (41%)
leucine-rich repeat 862..885 CDD:275380 6/25 (24%)
TLR7NP_057646.1 PCC 753..>837 CDD:188093 19/89 (21%)
LRR 27 772..795 6/22 (27%)
TIR 890..>993 CDD:214587
LRR 1 43..64 4/20 (20%)
leucine-rich repeat 48..69 CDD:275380 4/20 (20%)
LRR 2 65..87 7/28 (25%)
LRR_8 75..139 CDD:404697 22/97 (23%)
leucine-rich repeat 91..128 CDD:275380 16/70 (23%)
LRR 109..>434 CDD:443914 113/448 (25%)
LRR 3 110..126 7/23 (30%)
LRR 4 127..149 6/24 (25%)
leucine-rich repeat 129..173 CDD:275380 16/55 (29%)
LRR 5 151..170 7/27 (26%)
LRR 6 171..195 8/62 (13%)
LRR 7 203..226 7/25 (28%)
leucine-rich repeat 206..225 CDD:275380 6/21 (29%)
leucine-rich repeat 227..250 CDD:275380 10/50 (20%)
LRR 8 228..247 6/32 (19%)
LRR 9 248..275 8/26 (31%)
leucine-rich repeat 251..291 CDD:275380 11/50 (22%)
LRR 10 289..312 8/22 (36%)
leucine-rich repeat 292..315 CDD:275380 9/22 (41%)
LRR 11 314..337 8/22 (36%)
leucine-rich repeat 316..341 CDD:275380 10/24 (42%)
LRR 12 339..368 10/28 (36%)
leucine-rich repeat 342..371 CDD:275380 8/28 (29%)
LRR 13 369..392 3/22 (14%)
leucine-rich repeat 372..398 CDD:275380 6/25 (24%)
LRR 14 396..419 9/45 (20%)
leucine-rich repeat 399..422 CDD:275380 9/45 (20%)
LRR 15 421..443 6/21 (29%)
LRR 478..>785 CDD:443914 85/361 (24%)
LRR 16 492..515 3/22 (14%)
leucine-rich repeat 496..518 CDD:275380 4/21 (19%)
LRR 17 516..540 7/23 (30%)
leucine-rich repeat 519..543 CDD:275380 6/23 (26%)
LRR 18 541..564 8/22 (36%)
leucine-rich repeat 544..567 CDD:275380 8/22 (36%)
LRR 19 566..588 8/21 (38%)
leucine-rich repeat 568..597 CDD:275380 9/28 (32%)
LRR 20 595..618 3/22 (14%)
leucine-rich repeat 598..651 CDD:275380 13/57 (23%)
LRR 21 619..644 6/29 (21%)
leucine-rich repeat 621..643 CDD:275380 6/26 (23%)
LRR 22 649..672 8/22 (36%)
leucine-rich repeat 652..676 CDD:275380 8/64 (13%)
LRR 23 674..697 6/28 (21%)
leucine-rich repeat 677..700 CDD:275380 5/28 (18%)
LRR 24 698..721 10/25 (40%)
leucine-rich repeat 701..724 CDD:275380 10/25 (40%)
LRR 25 723..745 6/21 (29%)
leucine-rich repeat 725..748 CDD:275380 6/22 (27%)
LRR 26 746..769 6/22 (27%)
leucine-rich repeat 749..767 CDD:275380 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

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