DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and lrrc8c

DIOPT Version :10

Sequence 1:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:XP_004913784.1 Gene:lrrc8c / 493197 XenbaseID:XB-GENE-5797483 Length:796 Species:Xenopus tropicalis


Alignment Length:908 Identity:197/908 - (21%)
Similarity:321/908 - (35%) Gaps:316/908 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 CSLRGKEIQIWC---------------SHSNLP-----QIMDGLKAVERNIKGRIDELVLEN--- 74
            |:|:..:.:|.|               |:||||     .|..|  .||  :||...:|.|:.   
 Frog    43 CTLQVMQGKIICLPRVQPIHNISVYNVSNSNLPLNTPKPITPG--TVE--MKGLKTDLDLQQYSF 103

  Fly    75 -NQL---PALP--GRFFGSLQIVRLMLRHNSIERVSNGWL------NELEN-------------- 113
             ||:   .||.  .::|..|.::..::    ....||.|.      :::|:              
 Frog   104 INQMCYERALHWYAKYFPYLVLIHTLI----FMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWT 164

  Fly   114 --GLVEIFVVEPQLRSIPAESLN-GMINMLAI---TIQSEELKHLPDFSGLLSLTYLSVQTGALQ 172
              .|.::...||:.:.....:|| ..:|:..:   .::::.||.:|:     .........|||.
 Frog   165 TRALCKVSGEEPEEKDNRKNNLNKSNMNLSPLESPLVKTQSLKSIPE-----KFIVDKAAAGALD 224

  Fly   173 ----ELPSHLFRHLPKLQHIHITGGSGL-------TRLEA-------GLFDGLISLK------NL 213
                |....||..:.|.: ||:..|..|       |.|:.       |....|:|..      |:
 Frog   225 KKEGEQAKALFEKVKKFR-IHVEEGDLLYVMYVRQTILKVLKFLFIIGYNSALVSEVRFTVECNV 288

  Fly   214 DLSH-NGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVG------------RIVKDLEHLKKLRL 265
            |:.. .|.|  |......:.:|.| |||...:..||:.|            |.:|:.. .:.:||
 Frog   289 DIQDMTGYN--HFSCNHTMAHLFS-KLSFCYLCFVGVYGLTCLYTLYWLFYRSLKEYS-FEYVRL 349

  Fly   266 D---NNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLIRRIHPESLL 327
            :   |::..|..|.:|:       .|:.|               |...:|.:...:      .|.
 Frog   350 ETGINDIPDVKNDFAFM-------FHMID---------------QYDPLYSKRFAV------FLS 386

  Fly   328 QASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGTLEQLHLNHN 392
            :||.:.::.::: ||| ...|.||..|......| |::...:||.||                  
 Frog   387 EASENKLKQLNL-NNE-WTAEKLRQRLQTNASNR-LELQLFMLSGLP------------------ 430

  Fly   393 HLRLIERDALMAMPALRELRMR--NNSLSSDLPLPFWNLPGLKGLDLAQNQFARVDSQLLA---- 451
                   |.:..:..|:.|::.  ||.:   :|.....|..|:.|.|.|.. .::.|..||    
 Frog   431 -------DTIFEITELQSLKLEIINNVM---IPATIAQLDNLQELSLCQCS-VKIHSAALAFLKE 484

  Fly   452 --------------------GLPSLRRL--------DLSENGLIELAPNSFRHNPLLETLNISSN 488
                                ||.:|..|        |:|:|    :..:|||....|:.|.|.||
 Frog   485 NLKILRVKFDDVRELPPWMYGLRNLEELYLIGSLSPDVSKN----ITLDSFRELKSLKHLFIKSN 545

  Fly   489 ELTKIHSSTLI---HLERL-FEVDAS----YNQLKSVIAGLPRIVERISLKGNQITSLPAAASKD 545
             |:||....:.   ||::| ...|.:    .|.||.::                           
 Frog   546 -LSKIPQGAVDVSGHLQKLCIHNDGTKLVMLNNLKKMV--------------------------- 582

  Fly   546 LQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKD-TSFIGIQRLELLHLQENQL 609
                ||..|||....::.: .|.....:.|..|:|.:|.|:.::: .||..:::|.:|.|..|.:
 Frog   583 ----NLTELDLIHCDLDHI-HHSIFSLLALEELNLKENNLKSIQEIVSFQYLRKLTILKLWYNSI 642

  Fly   610 GEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYL 674
            ...... :..|..|..|....||:|.:....|..: :|..||||.|.||.| |......:||:|.
 Frog   643 THIPVE-IKKLTSLERLYFSHNKIEVLPSQLFLCH-KLRYLDLSYNDIRFI-PPEIGVMQSLQYF 704

  Fly   675 DLSGN-------------ALLDISVGLGNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLSNN 726
            .:|.|             .|:.:.:|..||.:|              |..||             
 Frog   705 SISCNKVESVPDELYFCKKLITLKIGKNNLCSL--------------SPKIG------------- 742

  Fly   727 LIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEF-VLADNKLVELKDHVFEELP 788
                       ||..|.|||:..|....:.|       ||.:. .|..|.|: ::|.:||.||
 Frog   743 -----------NLVLLSYLDIKGNHFETLPP-------ELGDCRALKKNGLI-VEDTLFETLP 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380
PCC 891..>936 CDD:188093
leucine-rich repeat 69..89 CDD:275380 7/28 (25%)
leucine-rich repeat 90..113 CDD:275380 3/28 (11%)
LRR 93..530 CDD:443914 109/544 (20%)
leucine-rich repeat 115..138 CDD:275380 5/23 (22%)
leucine-rich repeat 139..160 CDD:275380 3/23 (13%)
leucine-rich repeat 161..184 CDD:275380 6/26 (23%)
leucine-rich repeat 185..209 CDD:275380 8/37 (22%)
leucine-rich repeat 210..233 CDD:275380 5/29 (17%)
leucine-rich repeat 234..259 CDD:275380 10/36 (28%)
leucine-rich repeat 260..283 CDD:275380 6/25 (24%)
leucine-rich repeat 284..307 CDD:275380 2/22 (9%)
leucine-rich repeat 308..359 CDD:275380 11/50 (22%)
leucine-rich repeat 334..348 CDD:275378 3/13 (23%)
PLN00113 359..>824 CDD:215061 110/487 (23%)
leucine-rich repeat 360..383 CDD:275380 6/22 (27%)
leucine-rich repeat 384..407 CDD:275380 1/22 (5%)
leucine-rich repeat 408..431 CDD:275380 6/24 (25%)
leucine-rich repeat 432..455 CDD:275380 9/46 (20%)
leucine-rich repeat 456..476 CDD:275380 7/27 (26%)
leucine-rich repeat 480..501 CDD:275380 8/23 (35%)
leucine-rich repeat 505..517 CDD:275378 4/15 (27%)
leucine-rich repeat 525..550 CDD:275380 0/24 (0%)
leucine-rich repeat 551..574 CDD:275380 5/22 (23%)
leucine-rich repeat 575..598 CDD:275380 7/23 (30%)
leucine-rich repeat 599..622 CDD:275380 5/22 (23%)
leucine-rich repeat 623..646 CDD:275380 6/22 (27%)
leucine-rich repeat 647..670 CDD:275380 10/22 (45%)
leucine-rich repeat 671..693 CDD:275380 8/34 (24%)
leucine-rich repeat 694..717 CDD:275380 4/22 (18%)
leucine-rich repeat 718..741 CDD:275380 2/22 (9%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
leucine-rich repeat 766..789 CDD:275380 9/24 (38%)
leucine-rich repeat 790..813 CDD:275380
leucine-rich repeat 814..835 CDD:275380
leucine-rich repeat 838..861 CDD:275380
leucine-rich repeat 862..885 CDD:275380
lrrc8cXP_004913784.1 Pannexin_like 1..331 CDD:463622 65/304 (21%)
leucine-rich repeat 439..461 CDD:275380 6/24 (25%)
leucine-rich repeat 462..485 CDD:275380 7/23 (30%)
leucine-rich repeat 486..508 CDD:275380 2/21 (10%)
LRR 506..>765 CDD:443914 80/343 (23%)
leucine-rich repeat 509..536 CDD:275380 8/30 (27%)
leucine-rich repeat 537..559 CDD:275380 8/22 (36%)
leucine-rich repeat 560..583 CDD:275380 6/53 (11%)
leucine-rich repeat 584..606 CDD:275380 5/22 (23%)
leucine-rich repeat 607..631 CDD:275380 7/23 (30%)
leucine-rich repeat 632..654 CDD:275380 5/22 (23%)
leucine-rich repeat 655..677 CDD:275380 6/22 (27%)
leucine-rich repeat 701..723 CDD:275380 4/21 (19%)
leucine-rich repeat 724..746 CDD:275380 10/59 (17%)
Blue background indicates that the domain is not in the aligned region.

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