DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and CG7896

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster


Alignment Length:1480 Identity:347/1480 - (23%)
Similarity:585/1480 - (39%) Gaps:392/1480 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IFLLLCI---GINLIRAESCPP-SQAI-LPCRCSL-----RGK--EIQIWCS----HSNLPQIMD 54
            :.||.||   |..::....||. |.|: |||||::     .|:  .:.:.|.    |.:.||:..
  Fly    15 LLLLACIAHLGHPILAWRPCPELSPALRLPCRCNVVPFAATGQLGAVAMDCDRVVFHGDAPQLPY 79

  Fly    55 G--LKAVERNIKGRIDELVLENNQLPALPGRFFGSLQ--IVRLMLRHNSIERVSNGWLNELENGL 115
            |  :.|..:...|:           ..||.:.||.|:  |..|.|.:|.|.|:.....:.|::.|
  Fly    80 GAPIVAYTQRHSGQ-----------QVLPAQTFGQLKLTIEELDLSYNLIRRIPEKAFDGLKDSL 133

  Fly   116 VEIFVVEPQLRSIPAESLNGMINMLAITIQSEELKHLPDFSGLLSLTYLSVQTGALQELPSHLFR 180
            .|:.:.    .::..::||                  |.||           |..|     |:.:
  Fly   134 NELRLA----NNLLGDNLN------------------PIFS-----------TAEL-----HVLK 160

  Fly   181 HLPKLQHIHITGGSGLTRLEAGLFDGLISLKNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQIS 245
            :|..|.    ..|:.:..:|.||..|.:.||...:..|.|..:...:|:....|..|.|..||| 
  Fly   161 NLRLLD----LSGNKIKLIEEGLLKGCMDLKEFYIDRNSLTSVPTNSLNGPSALRHLSLRQNQI- 220

  Fly   246 DVGMVGRIVKD----LEHLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTP 306
                 |.::.|    ...|:.:.|.:|:|..|:..:|..|..:.|:.|..|||:.|....|.:..
  Fly   221 -----GSLLADSFNAQRQLEIIDLRHNVIRSIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQ 280

  Fly   307 QLKTIYLQNNLIRRIHPESLLQASGSGVEAVHMYNN-----EIGHVEALRALLDALPRLRYLDMS 366
            .|:.:.|..|...:....:|  |:..|::.:::.:|     :..|::.:|:       |..||:|
  Fly   281 SLQKLDLSENFFGQFPTVAL--AAVPGLKHLNLSSNMLQQLDYTHMQVVRS-------LESLDIS 336

  Fly   367 GNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLP---FWN 428
            .|.::.:..|..|..|.|:.|.|:.|.||.||.|||..:.:|:.|.:::|::   |.:|   ...
  Fly   337 RNTITTITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQTLIIKDNNI---LLVPGSALGR 398

  Fly   429 LPGLKGLDLAQNQFARVDSQLLAGLPS--LRRLDLSENGLIELAPNSFRHNPLLETLNISSNELT 491
            ||.|..|.|..|:.|.:.:::|..|.:  :..|.||.|.:.||.|.||:....|.||::|.|.|.
  Fly   399 LPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNVIRELPPGSFQMFSSLHTLDLSGNSLA 463

  Fly   492 KIHSSTLIHLE-RLFEVDASYNQLKSVIAGLPRI---VERISLKGNQITSLPAAASKDLQ----- 547
            .|::.|...|| .|..:..|.|:|.. :.|.|.:   :..:.|.||.:|.||:...::|:     
  Fly   464 VINADTFAGLESTLMALKLSQNRLTG-LGGAPWVLPELRSLDLSGNTLTELPSTIFEELENVQSL 527

  Fly   548 -----------------LPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIG 595
                             |..|:::|||...|.|:......|..:|:.:.|..|:|::|:|.||:.
  Fly   528 NLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQISGDLLAGLQDLKHIYLNDNQLQELQDGSFVN 592

  Fly   596 IQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRSI 660
            :..:..:.|..|::|.....|.:.:.:|:.|:|..|:|.|....:|:..:.:|:||:|.|.:..:
  Fly   593 LWNISSIDLSNNRIGSIRSGAFVNVMKLQKLDLHGNQLSAFKGEYFNTGTGIEELDISDNQLSYL 657

  Fly   661 SPTAFDTQRSLEYLDLSGNALLDISVGL-GNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLS 724
            .|::|.....|..:..:.|........| ..|..|..||||:||:..|:.........:..:.::
  Fly   658 FPSSFRIHPRLREIRAANNKFSFFPAELISTLQYLEHIDLSHNQLKTIEELDFARLPRLRVLLVA 722

  Fly   725 NNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADNKLVELKDHVFE---- 785
            ||.:..:.:..|.|..:||.|||:.|.:..:.....:||..|::..|..|:|.||.|.|||    
  Fly   723 NNQLDMVSEMAFHNSTQLQILDLAHNNLDRIGERTFEGLVRLEQLNLEGNRLSELSDGVFERTKL 787

  Fly   786 ---ELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNM---ENIGLRSMRNLEVLDLS 844
               |..:|..:.|:|..|..:..:.|..::    ::||:|..:.:   ::|    |.|::.:|||
  Fly   788 QMLENINLAHNRFEYAPLNALQRQFFFVSS----VDLSHNKIKELPGDDSI----MVNIKRIDLS 844

  Fly   845 TNGVKLVSTMPL--KAL-NWLVELKMDNNQICRIQGSPFETM-----PRLRVLSMRNNQLRSIKE 901
            .|        ||  ||: |.|.|.|....  ..:.|:..|.:     |.|:.|::.:|:|:::|.
  Fly   845 FN--------PLSSKAVHNVLNEPKTVRE--LSLAGTGIENLELLETPFLQFLNLSHNKLKNVKP 899

  Fly   902 RTFRNVRGNIAILDVDGNPIDC--NCEMQW--LSVW------------LQETNFPYPGPKCQDGR 950
            ..|:.|. .:..||:..|.::.  :..|.|  |.|.            :.::||         |:
  Fly   900 EVFQRVT-LLETLDLSSNQLESLEDLSMAWPQLQVLQSLDVSNNSFEIVSQSNF---------GK 954

  Fly   951 L--LRSARMER-SLCVGADIYGNERTDGNQLPLLNEHGDVFQRDLPDDFNDECEAGEGTRLPGDR 1012
            |  |||.|:.. ..|...     |:....|||.|   ..:...|||              |.|..
  Fly   955 LEMLRSLRLSHLPQCTRI-----EKNAFKQLPNL---VSLEAYDLP--------------LLGYL 997

  Fly  1013 PLVGESEYFYDQYVDATEAPDTTHSAISTSQ-RPKPTPTINSNIDLNNTILHTKYFNRKPQPGSG 1076
            .|.|..|......|...|..|   |:|.:.| :|...|.:.|                       
  Fly   998 DLQGILELLPGLEVLDIEVKD---SSIGSEQIQPLKHPRLKS----------------------- 1036

  Fly  1077 SPFTFFGYPLPSVSLGRFFGF--GDRGRKQRTDSNDDMP-----ATHRMAHISLPSGRGKTRMYQ 1134
              ....|..|.|:|.|...|.  .|...:.|..|.:.:|     ...|.:|:||           
  Fly  1037 --LGIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPVPRSSHLSL----------- 1088

  Fly  1135 PNSAEFEKYLKDQQKQEKLNIARNRYVDTDSTTSSMEDALSNESGSAATTVGVFRTTFREPSSIE 1199
                                                     |..||..|.               
  Fly  1089 -----------------------------------------NVEGSKITV--------------- 1097

  Fly  1200 RGGFRPIVPAHVGGFMPVHDPQQRRGLVEVVNITGNPSEIV---QGIGQRKFIPISTQARPKPTK 1261
                  :||..:...      :.||..:::..:..||  ||   .....|:::|           
  Fly  1098 ------LVPQFLNAL------EDRRASLQLQGLASNP--IVCDCNARALRRWLP----------- 1137

  Fly  1262 SSGESSETATYEVTETTPDITTTTP--LMQR---------IATSTTKASTTTTRSTTT------T 1309
            |||             .||:|..:|  |:.|         :.....:.:::|:|.|.:      |
  Fly  1138 SSG-------------MPDVTCASPAYLLNRKLIEVGDDELTCDARRMTSSTSRPTASVPHLLKT 1189

  Fly  1310 STTQVTPAENNASSSTELDSQYDDEDLEAQSVTLLRPPPLVQTTTAETIL 1359
            |:..||    .:||:||       |.|...|:...:||.|.:..|...::
  Fly  1190 SSQLVT----RSSSTTE-------EPLIIWSLEPTQPPSLKKMKTKAPLM 1228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380 4/19 (21%)
leucine-rich repeat 90..113 CDD:275380 7/22 (32%)
leucine-rich repeat 115..138 CDD:275380 4/22 (18%)
leucine-rich repeat 139..160 CDD:275380 3/20 (15%)
leucine-rich repeat 161..184 CDD:275380 4/22 (18%)
LRR_8 183..244 CDD:290566 15/60 (25%)
leucine-rich repeat 185..209 CDD:275380 6/23 (26%)
LRR_4 209..247 CDD:289563 11/37 (30%)
leucine-rich repeat 210..233 CDD:275380 5/22 (23%)
leucine-rich repeat 234..259 CDD:275380 8/28 (29%)
LRR_RI 250..492 CDD:238064 73/255 (29%)
LRR_8 259..318 CDD:290566 17/58 (29%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
leucine-rich repeat 284..307 CDD:275380 7/22 (32%)
leucine-rich repeat 308..359 CDD:275380 9/55 (16%)
leucine-rich repeat 334..348 CDD:275378 2/18 (11%)
LRR_8 358..418 CDD:290566 22/59 (37%)
leucine-rich repeat 360..383 CDD:275380 7/22 (32%)
leucine-rich repeat 384..407 CDD:275380 11/22 (50%)
LRR_8 406..466 CDD:290566 18/64 (28%)
leucine-rich repeat 408..431 CDD:275380 6/25 (24%)
leucine-rich repeat 432..455 CDD:275380 7/22 (32%)
LRR_RI 447..705 CDD:238064 79/286 (28%)
LRR_8 454..514 CDD:290566 22/62 (35%)
leucine-rich repeat 456..476 CDD:275380 9/19 (47%)
leucine-rich repeat 480..501 CDD:275380 8/20 (40%)
leucine-rich repeat 505..517 CDD:275378 3/11 (27%)
leucine-rich repeat 525..550 CDD:275380 8/46 (17%)
LRR_8 549..609 CDD:290566 17/59 (29%)
leucine-rich repeat 551..574 CDD:275380 7/22 (32%)
leucine-rich repeat 575..598 CDD:275380 8/22 (36%)
leucine-rich repeat 599..622 CDD:275380 4/22 (18%)
LRR_8 622..681 CDD:290566 16/58 (28%)
leucine-rich repeat 623..646 CDD:275380 7/22 (32%)
LRR_RI 647..896 CDD:238064 71/267 (27%)
leucine-rich repeat 647..670 CDD:275380 7/22 (32%)
leucine-rich repeat 671..693 CDD:275380 4/22 (18%)
leucine-rich repeat 694..717 CDD:275380 8/22 (36%)
LRR_8 716..776 CDD:290566 15/59 (25%)
leucine-rich repeat 718..741 CDD:275380 4/22 (18%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
LRR_8 765..824 CDD:290566 19/65 (29%)
leucine-rich repeat 766..789 CDD:275380 11/29 (38%)
leucine-rich repeat 790..813 CDD:275380 5/22 (23%)
leucine-rich repeat 814..835 CDD:275380 4/23 (17%)
leucine-rich repeat 838..861 CDD:275380 8/25 (32%)
LRR_8 862..921 CDD:290566 16/63 (25%)
leucine-rich repeat 862..885 CDD:275380 5/27 (19%)
leucine-rich repeat 886..906 CDD:275380 6/19 (32%)
TPKR_C2 919..>946 CDD:301599 7/42 (17%)
CG7896NP_651754.1 LRR_8 109..172 CDD:290566 19/104 (18%)
leucine-rich repeat 109..132 CDD:275380 6/22 (27%)
LRR_RI <132..338 CDD:238064 57/262 (22%)
leucine-rich repeat 133..161 CDD:275380 10/65 (15%)
LRR_8 160..220 CDD:290566 16/63 (25%)
leucine-rich repeat 162..185 CDD:275380 7/26 (27%)
leucine-rich repeat 186..209 CDD:275380 5/22 (23%)
leucine-rich repeat 210..233 CDD:275380 8/28 (29%)
LRR_8 232..290 CDD:290566 16/57 (28%)
leucine-rich repeat 234..257 CDD:275380 7/22 (32%)
leucine-rich repeat 258..281 CDD:275380 7/22 (32%)
LRR_RI 273..535 CDD:238064 75/274 (27%)
LRR_8 281..338 CDD:290566 13/65 (20%)
leucine-rich repeat 282..329 CDD:275380 8/48 (17%)
LRR_8 328..388 CDD:290566 23/66 (35%)
leucine-rich repeat 330..353 CDD:275380 7/22 (32%)
leucine-rich repeat 354..377 CDD:275380 11/22 (50%)
leucine-rich repeat 378..401 CDD:275380 6/25 (24%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 428..451 CDD:275380 9/22 (41%)
LRR_8 429..487 CDD:290566 22/57 (39%)
leucine-rich repeat 452..473 CDD:275380 8/20 (40%)
leucine-rich repeat 477..497 CDD:275378 6/20 (30%)
LRR_8 498..558 CDD:290566 12/59 (20%)
leucine-rich repeat 500..523 CDD:275380 7/22 (32%)
LRR_RI 502..769 CDD:238064 66/266 (25%)
leucine-rich repeat 524..547 CDD:275380 1/22 (5%)
leucine-rich repeat 548..571 CDD:275380 7/22 (32%)
LRR_8 572..630 CDD:290566 16/57 (28%)
leucine-rich repeat 572..595 CDD:275380 8/22 (36%)
leucine-rich repeat 596..619 CDD:275380 4/22 (18%)
LRR_8 619..678 CDD:290566 16/58 (28%)
leucine-rich repeat 620..643 CDD:275380 7/22 (32%)
leucine-rich repeat 644..667 CDD:275380 7/22 (32%)
LRR_8 666..726 CDD:290566 14/59 (24%)
leucine-rich repeat 668..691 CDD:275380 4/22 (18%)
leucine-rich repeat 692..715 CDD:275380 8/22 (36%)
LRR_8 714..774 CDD:290566 15/59 (25%)
leucine-rich repeat 716..739 CDD:275380 4/22 (18%)
leucine-rich repeat 740..761 CDD:275380 6/20 (30%)
leucine-rich repeat 764..789 CDD:275380 10/24 (42%)
leucine-rich repeat 790..810 CDD:275380 5/19 (26%)
leucine-rich repeat 818..850 CDD:275380 12/43 (28%)
leucine-rich repeat 863..883 CDD:275378 2/21 (10%)
LRR_RI <878..1070 CDD:238064 55/251 (22%)
LRR_8 884..944 CDD:290566 14/60 (23%)
LRR_4 884..925 CDD:289563 10/41 (24%)
leucine-rich repeat 884..907 CDD:275380 7/23 (30%)
leucine-rich repeat 908..933 CDD:275380 6/24 (25%)
leucine-rich repeat 934..955 CDD:275380 3/29 (10%)
leucine-rich repeat 958..982 CDD:275380 8/28 (29%)
leucine-rich repeat 983..1055 CDD:275380 23/116 (20%)
leucine-rich repeat 1009..1033 CDD:275380 7/26 (27%)
leucine-rich repeat 1058..1085 CDD:275380 5/26 (19%)
TPKR_C2 1121..1168 CDD:301599 15/72 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42484
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.910

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