DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atk and alrm

DIOPT Version :9

Sequence 1:	NP_001262113.1	Gene:	atk / 40266	FlyBaseID:	FBgn0036995	Length:	1535	Species:	Drosophila melanogaster
Sequence 2:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	105/424 - (24%)
Similarity:	171/424 - (40%)	Gaps:	97/424 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 LKSVIAGLPRI------------VERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPR 566
            |.|.||.:|.:            :|..||:..:......|:       ||..|.|..||::.:|:
  Fly    73 LNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGAS-------NLMSLFLGYNRLKDIPK 130

  Fly   567 HGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSN 631
            :.|.||..|..|.|..|:|:||.:.||..::.::.|.|.||||.:........:.:|.:|||..|
  Fly   131 NIFLGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGN 195

  Fly   632 KLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGN---------ALLDISVG 687
            :|:|:....|..|..|.:|:|:||...:........|.....||:|||         .:||:::.
  Fly   196 RLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAIA 260

  Fly   688 ------------------LGNLNNLRD------------IDLSYNQISRIQSDVIGGWRNVVEIR 722
                              |.| |:||:            :|||:|.:..:|.:.:..:.:::.:.
  Fly   261 HSCDLRRLTVYGVIHELDLHN-NSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLN 324

  Fly   723 LSNNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADN------------K 775
            ||.....||.:|.|:....||.||:|.|.|.:::......|..||.|....|            .
  Fly   325 LSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNNWNCDFLQLLMSS 389

  Fly   776 LVELKDHVFEE---LPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLRSMRN 837
            .|:.||..|.|   .|.|:..:                .:.:.....|:...:..|:.|..:...
  Fly   390 FVKRKDISFMEDITAPELVDDY----------------VDGIACWYESDKQSKKCESGGSDAAME 438

  Fly   838 LEVLDLSTNGVK----LVSTMPLKALNWLVELKM 867
            |.|:   .|.:|    ||....:|....|.|:||
  Fly   439 LSVV---RNEIKTFTELVEKKFVKVYRMLEEMKM 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atk	NP_001262113.1	leucine-rich repeat	69..89	CDD:275380
		leucine-rich repeat	90..113	CDD:275380
		leucine-rich repeat	115..138	CDD:275380
		leucine-rich repeat	139..160	CDD:275380
		leucine-rich repeat	161..184	CDD:275380
		LRR_8	183..244	CDD:290566
		leucine-rich repeat	185..209	CDD:275380
		LRR_4	209..247	CDD:289563
		leucine-rich repeat	210..233	CDD:275380
		leucine-rich repeat	234..259	CDD:275380
		LRR_RI	250..492	CDD:238064
		LRR_8	259..318	CDD:290566
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..359	CDD:275380
		leucine-rich repeat	334..348	CDD:275378
		LRR_8	358..418	CDD:290566
		leucine-rich repeat	360..383	CDD:275380
		leucine-rich repeat	384..407	CDD:275380
		LRR_8	406..466	CDD:290566
		leucine-rich repeat	408..431	CDD:275380
		leucine-rich repeat	432..455	CDD:275380
		LRR_RI	447..705	CDD:238064	65/241 (27%)
		LRR_8	454..514	CDD:290566	105/424 (25%)
		leucine-rich repeat	456..476	CDD:275380
		leucine-rich repeat	480..501	CDD:275380
		leucine-rich repeat	505..517	CDD:275378	1/2 (50%)
		leucine-rich repeat	525..550	CDD:275380	4/24 (17%)
		LRR_8	549..609	CDD:290566	23/59 (39%)
		leucine-rich repeat	551..574	CDD:275380	9/22 (41%)
		leucine-rich repeat	575..598	CDD:275380	9/22 (41%)
		leucine-rich repeat	599..622	CDD:275380	6/22 (27%)
		LRR_8	622..681	CDD:290566	20/67 (30%)
		leucine-rich repeat	623..646	CDD:275380	9/22 (41%)
		LRR_RI	647..896	CDD:238064	62/279 (22%)
		leucine-rich repeat	647..670	CDD:275380	6/22 (27%)
		leucine-rich repeat	671..693	CDD:275380	9/48 (19%)
		leucine-rich repeat	694..717	CDD:275380	7/34 (21%)
		LRR_8	716..776	CDD:290566	18/71 (25%)
		leucine-rich repeat	718..741	CDD:275380	6/22 (27%)
		leucine-rich repeat	742..763	CDD:275380	7/20 (35%)
		LRR_8	765..824	CDD:290566	12/73 (16%)
		leucine-rich repeat	766..789	CDD:275380	9/37 (24%)
		leucine-rich repeat	790..813	CDD:275380	1/22 (5%)
		leucine-rich repeat	814..835	CDD:275380	3/20 (15%)
		leucine-rich repeat	838..861	CDD:275380	7/26 (27%)
		LRR_8	862..921	CDD:290566	4/6 (67%)
		leucine-rich repeat	862..885	CDD:275380	4/6 (67%)
		leucine-rich repeat	886..906	CDD:275380
		TPKR_C2	919..>946	CDD:301599
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	73/277 (26%)
		LRR_8	91..149	CDD:290566	18/64 (28%)
		leucine-rich repeat	91..114	CDD:275380	4/29 (14%)
		leucine-rich repeat	115..138	CDD:275380	9/22 (41%)
		LRR_8	138..197	CDD:290566	20/58 (34%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		leucine-rich repeat	163..186	CDD:275380	6/22 (27%)
		LRR_8	185..243	CDD:290566	18/57 (32%)
		leucine-rich repeat	187..210	CDD:275380	9/22 (41%)
		leucine-rich repeat	211..283	CDD:275380	15/72 (21%)
		leucine-rich repeat	284..319	CDD:275380	7/34 (21%)
		LRR_8	318..377	CDD:290566	17/58 (29%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..365	CDD:275380	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010