DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and NRROS

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_940967.1 Gene:NRROS / 375387 HGNCID:24613 Length:692 Species:Homo sapiens


Alignment Length:685 Identity:186/685 - (27%)
Similarity:261/685 - (38%) Gaps:222/685 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   424 LPFWNLPGL----------KGLDLAQNQ--------FARVDSQLLAGLPS-----LRRLDLSENG 465
            ||.|...|.          .|...|.:|        .|....|.||.:||     .|.|.|..|.
Human     4 LPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANP 68

  Fly   466 LIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHLERL----FEVDASYNQLKSVIAGLPRIVE 526
            |..|..:|.:..||||:|::.|           .||||:    |:   ....|:|::.|     :
Human    69 LKTLWNHSLQPYPLLESLSLHS-----------CHLERISRGAFQ---EQGHLRSLVLG-----D 114

  Fly   527 RISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRI-EQLPRHGFQGAMELRVLSLAQNELRQLKD 590
            ....:..:.|:....|     ||.||.||||.|.: |.:.....|....||.:|||.|.:.:|.|
Human   115 NCLSENYEETAAALHA-----LPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDD 174

  Fly   591 TSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRN 655
            :.|.|::||..|.||.|.:.|.:..|...|||||:|||..|.|..|.|   ...:||..|::|.|
Human   175 SVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVD---FGLTRLRVLNVSYN 236

  Fly   656 LIRSISPTAFDTQRSLEYLDLSGNALL-----------------DISVGL--------------- 688
            ::.....|..:....||.||||.|.||                 |.::|.               
Human   237 VLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVA 301

  Fly   689 ------GNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIR---LSNNLIVELQQGTFRNLPKLQY 744
                  ||:.|:..:.| :.:.|  .||       :.::|   :|.|....|..|..|.:|.|.:
Human   302 QFLLVDGNVTNITTVSL-WEEFS--SSD-------LADLRFLDMSQNQFQYLPDGFLRKMPSLSH 356

  Fly   745 LDLSSN-----EIRNVE-PGALKGLDELQEFVLADNKLVELKDHVFEELPSLLAS----HFQYNK 799
            |:|..|     .||..| ||||..||      |:.|:|.||  |:...|.|.|.|    :...|:
Human   357 LNLHQNCLMTLHIREHEPPGALTELD------LSHNQLSEL--HLAPGLASCLGSLRLFNLSSNQ 413

  Fly   800 LRYISPESFHNANSLVFLNLSNNH--------------------FRNM--------ENIGLRSM- 835
            |..:.|..|.||.::..|::|:|.                    ||||        |..||.:: 
Human   414 LLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALP 478

  Fly   836 ------RNLEVLDLSTN-GVKLVSTMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMRN 893
                  .:|..||||:| ||...|..||:                       :..|.|:|||:||
Human   479 DCPFQGTSLTYLDLSSNWGVLNGSLAPLQ-----------------------DVAPMLQVLSLRN 520

  Fly   894 NQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFP-YPGPKCQDGRLLR---- 953
            ..|.|.......:..||:..||:.||.:               |.|| :.|....:...||    
Human   521 MGLHSSFMALDFSGFGNLRDLDLSGNCL---------------TTFPRFGGSLALETLDLRRNSL 570

  Fly   954 --------SARMERSL-----------CVGADIYG 969
                    |.::.|.|           |.|.|.:|
Human   571 TALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWG 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
LRR_8 183..244 CDD:290566
leucine-rich repeat 185..209 CDD:275380
LRR_4 209..247 CDD:289563
leucine-rich repeat 210..233 CDD:275380
leucine-rich repeat 234..259 CDD:275380
LRR_RI 250..492 CDD:238064 26/90 (29%)
LRR_8 259..318 CDD:290566
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..359 CDD:275380
leucine-rich repeat 334..348 CDD:275378
LRR_8 358..418 CDD:290566
leucine-rich repeat 360..383 CDD:275380
leucine-rich repeat 384..407 CDD:275380
LRR_8 406..466 CDD:290566 17/64 (27%)
leucine-rich repeat 408..431 CDD:275380 3/6 (50%)
leucine-rich repeat 432..455 CDD:275380 7/40 (18%)
LRR_RI 447..705 CDD:238064 90/305 (30%)
LRR_8 454..514 CDD:290566 20/68 (29%)
leucine-rich repeat 456..476 CDD:275380 7/19 (37%)
leucine-rich repeat 480..501 CDD:275380 4/20 (20%)
leucine-rich repeat 505..517 CDD:275378 2/11 (18%)
leucine-rich repeat 525..550 CDD:275380 3/24 (13%)
LRR_8 549..609 CDD:290566 26/60 (43%)
leucine-rich repeat 551..574 CDD:275380 9/23 (39%)
leucine-rich repeat 575..598 CDD:275380 10/22 (45%)
leucine-rich repeat 599..622 CDD:275380 8/22 (36%)
LRR_8 622..681 CDD:290566 23/58 (40%)
leucine-rich repeat 623..646 CDD:275380 9/22 (41%)
LRR_RI 647..896 CDD:238064 87/335 (26%)
leucine-rich repeat 647..670 CDD:275380 5/22 (23%)
leucine-rich repeat 671..693 CDD:275380 13/59 (22%)
leucine-rich repeat 694..717 CDD:275380 4/22 (18%)
LRR_8 716..776 CDD:290566 22/68 (32%)
leucine-rich repeat 718..741 CDD:275380 6/25 (24%)
leucine-rich repeat 742..763 CDD:275380 11/26 (42%)
LRR_8 765..824 CDD:290566 19/82 (23%)
leucine-rich repeat 766..789 CDD:275380 7/22 (32%)
leucine-rich repeat 790..813 CDD:275380 8/26 (31%)
leucine-rich repeat 814..835 CDD:275380 10/48 (21%)
leucine-rich repeat 838..861 CDD:275380 11/23 (48%)
LRR_8 862..921 CDD:290566 15/58 (26%)
leucine-rich repeat 862..885 CDD:275380 0/22 (0%)
leucine-rich repeat 886..906 CDD:275380 8/19 (42%)
TPKR_C2 919..>946 CDD:301599 5/27 (19%)
NRROSNP_940967.1 leucine-rich repeat 42..61 CDD:275380 5/18 (28%)
LRR 1. /evidence=ECO:0000255 58..79 7/20 (35%)
leucine-rich repeat 62..82 CDD:275380 6/19 (32%)
LRR_RI 76..>285 CDD:238064 74/235 (31%)
LRR_8 81..144 CDD:290566 25/86 (29%)
LRR 2. /evidence=ECO:0000255 82..103 10/34 (29%)
leucine-rich repeat 83..106 CDD:275380 9/36 (25%)
LRR 3. /evidence=ECO:0000255 106..127 4/25 (16%)
leucine-rich repeat 107..133 CDD:275380 6/35 (17%)
LRR 4. /evidence=ECO:0000255 133..155 8/21 (38%)
leucine-rich repeat 134..158 CDD:275380 9/23 (39%)
LRR_8 157..217 CDD:290566 27/59 (46%)
LRR 5. /evidence=ECO:0000255 158..179 9/20 (45%)
leucine-rich repeat 159..182 CDD:275380 10/22 (45%)
LRR 6. /evidence=ECO:0000255 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
LRR 7. /evidence=ECO:0000255 206..227 10/23 (43%)
leucine-rich repeat 207..227 CDD:275380 9/22 (41%)
leucine-rich repeat 228..251 CDD:275380 5/22 (23%)
LRR 8. /evidence=ECO:0000255 228..239 4/10 (40%)
LRR 9. /evidence=ECO:0000255 251..272 9/20 (45%)
leucine-rich repeat 252..273 CDD:275380 9/20 (45%)
LRR 10. /evidence=ECO:0000255 273..294 2/20 (10%)
LRR 11. /evidence=ECO:0000255 329..350 5/20 (25%)
LRR_8 330..388 CDD:290566 22/63 (35%)
leucine-rich repeat 330..353 CDD:275380 6/22 (27%)
LRR 12. /evidence=ECO:0000255 353..374 6/20 (30%)
leucine-rich repeat 354..377 CDD:275380 8/22 (36%)
LRR_RI 357..594 CDD:238064 73/282 (26%)
LRR 13. /evidence=ECO:0000255 377..398 10/28 (36%)
LRR_8 378..438 CDD:290566 22/67 (33%)
leucine-rich repeat 378..403 CDD:275380 12/32 (38%)
LRR 14. /evidence=ECO:0000255 403..424 5/20 (25%)
leucine-rich repeat 404..427 CDD:275380 6/22 (27%)
LRR 15. /evidence=ECO:0000255 427..447 3/19 (16%)
leucine-rich repeat 428..463 CDD:275380 7/34 (21%)
LRR 16. /evidence=ECO:0000255 463..484 3/20 (15%)
leucine-rich repeat 464..486 CDD:275380 3/21 (14%)
LRR 17. /evidence=ECO:0000255 486..507 10/20 (50%)
leucine-rich repeat 487..512 CDD:275380 11/47 (23%)
LRR 18. /evidence=ECO:0000255 512..534 8/21 (38%)
LRR_8 513..570 CDD:290566 20/71 (28%)
leucine-rich repeat 513..537 CDD:275380 8/23 (35%)
LRR 19. /evidence=ECO:0000255 537..558 9/35 (26%)
leucine-rich repeat 538..559 CDD:275380 8/35 (23%)
LRR 20. /evidence=ECO:0000255 559..580 2/20 (10%)
LRR 21. /evidence=ECO:0000255 585..594 1/8 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138601at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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