DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and 18w

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster


Alignment Length:1455 Identity:318/1455 - (21%)
Similarity:511/1455 - (35%) Gaps:459/1455 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 SEELKHLPDFSGLLSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGGSGLTRLEAGLFDGLISL 210
            |:||.|                   ..||...|||.|.||..:.| ....|.|:....|:||:||
  Fly    72 SQELLH-------------------ASELAPGLFRQLQKLSELRI-DACKLQRVPPNAFEGLMSL 116

  Fly   211 KNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVGRIVKDLEHLKKLRLDNNLITVIED 275
            |.|.|.                       |||.:...|      |.||              :..
  Fly   117 KRLTLE-----------------------SHNAVWGPG------KTLE--------------LHG 138

  Fly   276 GSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLIRRIH----PESLLQAS------ 330
            .||..|..||||||.||.|.:|..|.:...|.|:.:.|..|.||...    .|.|...|      
  Fly   139 QSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNAN 203

  Fly   331 -----GSGVEAVHMYNNEIGHVEALRALLDA-----LPRLRYLDMSGNLLSELPYGALRGHGTLE 385
                 ||.::.:.:..||      ||:|.||     |.||:.|.:..|.:|.|...||.|..:|.
  Fly   204 GAVSGGSELQTLDVSFNE------LRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLR 262

  Fly   386 QLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWN-LPGLKGLDLAQNQFA--RVDS 447
            .|::::|||..:..:|......||||.::.|.| .:||....: |..|..|||:.||..  .||:
  Fly   263 VLNISYNHLVSLPSEAFAGNKELRELHLQGNDL-YELPKGLLHRLEQLLVLDLSGNQLTSHHVDN 326

  Fly   448 QLLAGLPSLRRLDLSENGLIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHLERLFEVDASYN 512
            ...|||..|..|:||.|.|..:...:|:....|:.|::.:|.:..|.....:.|..|..::.:.|
  Fly   327 STFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAEN 391

  Fly   513 QLKS----VIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAM 573
            :|.:    :..|| .::.:::|..|.::.:.:.|.::..  :|:.||||.|::.::| ...|...
  Fly   392 RLHTLDNRIFNGL-YVLTKLTLNNNLVSIVESQAFRNCS--DLKELDLSSNQLTEVP-EAVQDLS 452

  Fly   574 ELRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITD 638
            .|:.|.|.:|::.:.|:.:|..:.:|..|.|.:|::|.........|..|..|||..|::::|..
  Fly   453 MLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIER 517

  Fly   639 NFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGNAL--------------LDIS---- 685
            ..|..|:.:|.:.|.:|.:..|: ..|.|..||.:|:||.|.|              |||.    
  Fly   518 GAFDKNTEIEAIRLDKNFLTDIN-GIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYI 581

  Fly   686 VGLGNLNNLRD------IDLSYNQISRIQSDVIGGWRNVVEIR-LSNNLIVELQQGTFRNLPKLQ 743
            ..|||...|::      :|.|:|:|:.|.:..:   .|.:|:. ::||:|.::|..||.:..:|.
  Fly   582 EALGNYYKLQEEIRVTTLDASHNRITEIGAMSV---PNSIELLFINNNIIGQIQANTFVDKTRLA 643

  Fly   744 YLDLSSNEIRNVEPGALK-----GLDELQEFVLADN-----------------------KLVEL- 779
            .:||.:|.:..:...||:     ....:.||.|..|                       .:|:| 
  Fly   644 RVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLG 708

  Fly   780 ---------KDHVFEELPSLLASHF---------------QYN--KLRYISP---ESFHNA---- 811
                     :......|.||.||.|               :|.  :...|.|   ..||:|    
  Fly   709 NIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWAT 773

  Fly   812 ----------------------------NSL----------------VFLNLSNNHFRNMENIGL 832
                                        |::                ::||.||  ...::|..|
  Fly   774 NIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASN--LMTLQNGSL 836

  Fly   833 RSMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMRNNQLR 897
            ..:.||.||.|..|.:..:.....::|..|.||.:.||.:..|..:.||.:..|.||.:.||:|.
  Fly   837 AQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLS 901

  Fly   898 SIKERTFRNVRGNIAILDVDGNPIDCNCEM-----QWLS---VWLQETNFPYPGPKCQDGRLLRS 954
            |:....:|:   ::..|.:..|...|.|:.     |::|   :.:::.:..|    |.|..:.|.
  Fly   902 SLPHLQYRH---SLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIY----CLDAGIKRE 959

  Fly   955 ARMERSLCVGADI------------YGNERTDGNQLPLLN------------------------- 982
            ..:..:|..|.|.            ...:...|.:||||.                         
  Fly   960 LELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMW 1024

  Fly   983 -------------------------------------------EHGD------VFQRDLPDDFND 998
                                                       |||.      :.|||||...: 
  Fly  1025 LFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQAS- 1088

  Fly   999 ECEAGEGTRLPGDRPLV------------GESEY---FYDQ---------YVDATEAPDTTHSAI 1039
            ..:..||.|  ..|.::            ...|:   |::.         .::.|..........
  Fly  1089 HLQLVEGAR--ASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVA 1151

  Fly  1040 STSQRPKPTPTINSNIDLNNTILHTKYFNRKPQPGSGSPFTFFGYPLPSVSLGRFFGFGDRGRKQ 1104
            ..|...|..|:       |..:...:||..|           ..|.:|       .....||...
  Fly  1152 ELSPYLKSVPS-------NRLLTCDRYFWEK-----------LRYAIP-------IELSPRGNNY 1191

  Fly  1105 RTDSNDDMPATHRMAHISLPSGRGKTRMYQPNSAEFEKYLKDQQKQEKLNIARNRYVDTDSTTSS 1169
            ..|.::         ....|...|......|....:  |..::.:           .:..|.|::
  Fly  1192 TLDHHE---------RFKQPVSPGMIFRQAPPPPAY--YCTEEME-----------ANYSSATTA 1234

  Fly  1170 MEDALSNESGSAATTVGVFRTTFREPS-----SIE-------RGGFRPIVPAHVGGFMPVHDPQQ 1222
            .........|.||..|.......|.||     |||       :.....::|.   |.|..|..||
  Fly  1235 TPSPRPTRPGGAARIVDSMPMPMRPPSEHIYHSIESEYSAYDQHEALSMIPT---GLMHQHQQQQ 1296

  Fly  1223 RRGLVEVVNITGNPSEIVQGIGQRKFIPISTQARPKPTKSSGESSETATYEVTETTPDITTTTPL 1287
            .|...:      ...:..|.:.|.:|..:..||.|.|                        :.|:
  Fly  1297 LRLHQQ------QQQQQQQRLLQPQFRAMPQQAIPAP------------------------SAPV 1331

  Fly  1288 MQRIATSTTKASTTTTRSTTTTSTT 1312
            ..|..:..::|| |:|:||...||:
  Fly  1332 HLRSGSGLSQAS-TSTQSTAQASTS 1355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380 4/13 (31%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
LRR_8 183..244 CDD:290566 16/60 (27%)
leucine-rich repeat 185..209 CDD:275380 7/23 (30%)
LRR_4 209..247 CDD:289563 8/37 (22%)
leucine-rich repeat 210..233 CDD:275380 4/22 (18%)
leucine-rich repeat 234..259 CDD:275380 6/24 (25%)
LRR_RI 250..492 CDD:238064 81/264 (31%)
LRR_8 259..318 CDD:290566 18/58 (31%)
leucine-rich repeat 260..283 CDD:275380 3/22 (14%)
leucine-rich repeat 284..307 CDD:275380 11/22 (50%)
leucine-rich repeat 308..359 CDD:275380 18/70 (26%)
leucine-rich repeat 334..348 CDD:275378 2/13 (15%)
LRR_8 358..418 CDD:290566 20/59 (34%)
leucine-rich repeat 360..383 CDD:275380 8/22 (36%)
leucine-rich repeat 384..407 CDD:275380 6/22 (27%)
LRR_8 406..466 CDD:290566 25/62 (40%)
leucine-rich repeat 408..431 CDD:275380 9/23 (39%)
leucine-rich repeat 432..455 CDD:275380 11/24 (46%)
LRR_RI 447..705 CDD:238064 74/285 (26%)
LRR_8 454..514 CDD:290566 14/59 (24%)
leucine-rich repeat 456..476 CDD:275380 7/19 (37%)
leucine-rich repeat 480..501 CDD:275380 4/20 (20%)
leucine-rich repeat 505..517 CDD:275378 2/15 (13%)
leucine-rich repeat 525..550 CDD:275380 3/24 (13%)
LRR_8 549..609 CDD:290566 18/59 (31%)
leucine-rich repeat 551..574 CDD:275380 8/22 (36%)
leucine-rich repeat 575..598 CDD:275380 6/22 (27%)
leucine-rich repeat 599..622 CDD:275380 6/22 (27%)
LRR_8 622..681 CDD:290566 20/58 (34%)
leucine-rich repeat 623..646 CDD:275380 8/22 (36%)
LRR_RI 647..896 CDD:238064 84/379 (22%)
leucine-rich repeat 647..670 CDD:275380 6/22 (27%)
leucine-rich repeat 671..693 CDD:275380 12/39 (31%)
leucine-rich repeat 694..717 CDD:275380 6/28 (21%)
LRR_8 716..776 CDD:290566 18/88 (20%)
leucine-rich repeat 718..741 CDD:275380 7/23 (30%)
leucine-rich repeat 742..763 CDD:275380 6/25 (24%)
LRR_8 765..824 CDD:290566 23/159 (14%)
leucine-rich repeat 766..789 CDD:275380 7/55 (13%)
leucine-rich repeat 790..813 CDD:275380 10/74 (14%)
leucine-rich repeat 814..835 CDD:275380 6/36 (17%)
leucine-rich repeat 838..861 CDD:275380 6/22 (27%)
LRR_8 862..921 CDD:290566 18/58 (31%)
leucine-rich repeat 862..885 CDD:275380 8/22 (36%)
leucine-rich repeat 886..906 CDD:275380 7/19 (37%)
TPKR_C2 919..>946 CDD:301599 6/34 (18%)
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 10/37 (27%)
leucine-rich repeat 92..115 CDD:275380 7/23 (30%)
LRR_8 115..181 CDD:290566 30/108 (28%)
leucine-rich repeat 116..146 CDD:275380 14/72 (19%)
leucine-rich repeat 147..170 CDD:275380 11/22 (50%)
leucine-rich repeat 171..201 CDD:275380 8/29 (28%)
LRR_RI 210..464 CDD:238064 76/264 (29%)
leucine-rich repeat 212..236 CDD:275380 8/29 (28%)
LRR_8 235..295 CDD:290566 20/59 (34%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
LRR_8 283..345 CDD:290566 25/62 (40%)
leucine-rich repeat 285..308 CDD:275380 9/23 (39%)
leucine-rich repeat 309..334 CDD:275380 11/24 (46%)
LRR_8 334..393 CDD:290566 14/58 (24%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 5/22 (23%)
LRR_8 382..441 CDD:290566 14/61 (23%)
leucine-rich repeat 383..406 CDD:275380 5/23 (22%)
leucine-rich repeat 407..430 CDD:275380 3/24 (13%)
LRR_8 431..488 CDD:290566 18/57 (32%)
leucine-rich repeat 431..451 CDD:275380 8/20 (40%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..559 CDD:290566 26/82 (32%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 6/22 (27%)
leucine-rich repeat 590..617 CDD:275380 6/29 (21%)
leucine-rich repeat 618..641 CDD:275380 7/22 (32%)
leucine-rich repeat 642..689 CDD:275380 10/46 (22%)
LRRCT 679..736 CDD:214507 9/56 (16%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 13/56 (23%)
leucine-rich repeat 797..817 CDD:275380 1/19 (5%)
leucine-rich repeat 818..841 CDD:275380 6/24 (25%)
LRR_8 841..900 CDD:290566 20/58 (34%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 15/40 (38%)
leucine-rich repeat 866..889 CDD:275380 8/22 (36%)
leucine-rich repeat 890..911 CDD:275380 8/23 (35%)
TIR 1045..1183 CDD:214587 24/165 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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