DRSC/TRiP Functional Genomics Resources

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Protein Alignment atk and Tlr9

DIOPT Version :10

Sequence 1:NP_649228.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_937764.1 Gene:Tlr9 / 338457 RGDID:631352 Length:1032 Species:Rattus norvegicus


Alignment Length:937 Identity:233/937 - (24%)
Similarity:367/937 - (39%) Gaps:254/937 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 LKHLPDFSGL---LSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGG---SGLTRL-------- 199
            ||.:|.||..   .::|.||:....:..|.:..|.|||.::.:::...   .||:.|        
  Rat    50 LKSVPHFSAAEPRSNITSLSLIANRIHHLHNLDFVHLPNVRQLNLKWNCPPPGLSPLHFSCRMTI 114

  Fly   200 EAGLFDGLISLKNLDLSHNGLNWIHLRALSRLP-NLVSLKLSHNQISDVGMVGRIVKD------L 257
            |...|..:..|:.|:||:||:.     .:.||| :|.:|.|||..|        :|.|      |
  Rat   115 EPKTFLAMRMLEELNLSYNGIT-----TVPRLPSSLTNLSLSHTNI--------LVLDASSLAGL 166

  Fly   258 EHLKKLRLD---------NNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYL 313
            ..|:.|.:|         |..:.|..| :|:.|.||:.|.|..|.:||:....   .|.|:.:.|
  Rat   167 HSLRVLFMDGNCYYKNPCNGAVNVTPD-AFLGLSNLTHLSLKYNNLTEVPRQL---PPSLEYLLL 227

  Fly   314 QNNLIRRIHPESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGAL 378
            ..|||.::.||.|..                            |..||.||:.||.         
  Rat   228 SYNLIVKLGPEDLAN----------------------------LTSLRVLDVGGNC--------- 255

  Fly   379 RGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDL-PLPFWNLPGLKGLDLAQNQF 442
                                |....|.....|.|.:    |.|| |..|.:|..|:||.|..:..
  Rat   256 --------------------RRCDHAPDLCTECRQK----SLDLHPQTFHHLSHLEGLVLKDSSL 296

  Fly   443 ARVDSQLLAGLPSLRRLDLSENGLIEL--APNSFRHNPLLETLNISSNELTKIHSSTLIHLERLF 505
            ..::|:...||.:|..||||||.|.|.  ..::|::...|..|::|.|...|: |...:||...|
  Rat   297 HSLNSKWFQGLVNLSVLDLSENFLYESINKTSAFQNLTRLRKLDLSFNYCKKV-SFARLHLASSF 360

  Fly   506 EVDASYNQL-----------KSV---IAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDL 556
            :...|..:|           |:.   :||||:: ..:.|:.|.|.....:.....:.  ||.:||
  Rat   361 KSLVSLQELNMNGIFFRLLNKNTLRWLAGLPKL-HTLHLQMNFINQAQLSVFSTFRA--LRFVDL 422

  Fly   557 SQNRIEQLP---------------------------------RHGFQGAMELR-VLSLAQNELRQ 587
            |.|||...|                                 ::.......|| .:.|::|.|..
  Rat   423 SNNRISGPPTLSRVAPEKADEAEKGVPWPASLTPALPSTPVSKNFMVRCKNLRFTMDLSRNNLVT 487

  Fly   588 LKDTSFIGIQRLELLHLQENQLGEA-DERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLD 651
            :|...|:.:..|:.|.|..|.:.:| :....|||..|:.|:|..|||:......||...:|:.||
  Rat   488 IKPEMFVNLSHLQCLSLSHNCIAQAVNGSQFLPLTNLKVLDLSYNKLDLYHSKSFSELPQLQALD 552

  Fly   652 LSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISVG-----LGNLNNLRDIDLSYNQI-SRIQSD 710
            ||.|      ...|..|                .:|     |.||:.|:::.|::|.| ||:.| 
  Rat   553 LSYN------SQPFSMQ----------------GIGHNFSFLANLSRLQNLSLAHNDIHSRVSS- 594

  Fly   711 VIGGWRNVVEIRLSNNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADNK 775
                       ||.:.              .::|||.|.|       |..:..||          
  Rat   595 -----------RLYST--------------SVEYLDFSGN-------GVGRMWDE---------- 617

  Fly   776 LVELKDHVFEELPSLLASHFQYNKLRYISPESF-HNANSLVFLNLSNNHFRNMENIGLRSMRNLE 839
             .:|..:.|::|.||:......|||..:.|::. :...||..|:..:||........|..:.||.
  Rat   618 -EDLYLYFFQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFLPNLR 681

  Fly   840 VLDLSTNGVKLVS--TMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMRNNQLRSIKER 902
            .|||:.|.:|.::  |:|...|  |.:|.:.:|.|..:..:.|.....|:.:::.:|.|:::...
  Rat   682 DLDLAGNLLKALTNGTLPNGTL--LQKLDVSSNSIVFVVPAFFALAVELKEVNLSHNILKTVDRS 744

  Fly   903 TFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQ-ETNFP--YPGPKCQDGRLLRSARM---ERSL 961
            .|..:..|:.:|||..||:.|.|...::.:.|: :|..|  ..|.||...|.|:...:   :..|
  Rat   745 WFGPIVMNLTVLDVSSNPLHCACGAPFVDLLLEVQTKVPGLANGVKCGSPRQLQGRSIFAQDLRL 809

  Fly   962 C----VGADIYGNER---TDGNQLPLL 981
            |    :..|.:|...   ..|..||||
  Rat   810 CLDDVLSRDCFGLSLLAVAVGTVLPLL 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_649228.1 leucine-rich repeat 886..906 CDD:275380 4/19 (21%)
PCC 891..>936 CDD:188093 12/45 (27%)
leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
LRR 93..530 CDD:443914 110/427 (26%)
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380 5/13 (38%)
leucine-rich repeat 161..184 CDD:275380 7/22 (32%)
leucine-rich repeat 185..209 CDD:275380 5/34 (15%)
leucine-rich repeat 210..233 CDD:275380 9/23 (39%)
leucine-rich repeat 234..259 CDD:275380 9/30 (30%)
leucine-rich repeat 260..283 CDD:275380 8/31 (26%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..359 CDD:275380 9/50 (18%)
leucine-rich repeat 334..348 CDD:275378 0/13 (0%)
PLN00113 359..>824 CDD:215061 126/523 (24%)
leucine-rich repeat 360..383 CDD:275380 6/22 (27%)
leucine-rich repeat 384..407 CDD:275380 2/22 (9%)
leucine-rich repeat 408..431 CDD:275380 8/23 (35%)
leucine-rich repeat 432..455 CDD:275380 7/22 (32%)
leucine-rich repeat 456..476 CDD:275380 10/21 (48%)
leucine-rich repeat 480..501 CDD:275380 6/20 (30%)
leucine-rich repeat 505..517 CDD:275378 4/22 (18%)
leucine-rich repeat 525..550 CDD:275380 3/24 (13%)
leucine-rich repeat 551..574 CDD:275380 9/55 (16%)
leucine-rich repeat 575..598 CDD:275380 7/23 (30%)
leucine-rich repeat 599..622 CDD:275380 8/23 (35%)
leucine-rich repeat 623..646 CDD:275380 8/22 (36%)
leucine-rich repeat 647..670 CDD:275380 8/22 (36%)
leucine-rich repeat 671..693 CDD:275380 4/26 (15%)
leucine-rich repeat 694..717 CDD:275380 7/23 (30%)
leucine-rich repeat 718..741 CDD:275380 2/22 (9%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
leucine-rich repeat 766..789 CDD:275380 3/22 (14%)
leucine-rich repeat 790..813 CDD:275380 5/23 (22%)
leucine-rich repeat 814..835 CDD:275380 5/20 (25%)
leucine-rich repeat 838..861 CDD:275380 9/24 (38%)
leucine-rich repeat 862..885 CDD:275380 5/22 (23%)
Tlr9NP_937764.1 leucine-rich repeat 43..64 CDD:275380 5/13 (38%)
LRR_8 63..135 CDD:404697 18/71 (25%)
leucine-rich repeat 65..88 CDD:275380 7/22 (32%)
leucine-rich repeat 89..124 CDD:275380 5/34 (15%)
LRR <125..>383 CDD:443914 88/336 (26%)
leucine-rich repeat 125..144 CDD:275380 9/23 (39%)
leucine-rich repeat 145..168 CDD:275380 9/30 (30%)
leucine-rich repeat 169..200 CDD:275380 8/31 (26%)
leucine-rich repeat 201..221 CDD:275380 6/22 (27%)
leucine-rich repeat 222..245 CDD:275380 9/50 (18%)
leucine-rich repeat 246..285 CDD:275380 16/71 (23%)
leucine-rich repeat 286..309 CDD:275380 7/22 (32%)
leucine-rich repeat 310..335 CDD:275380 10/24 (42%)
leucine-rich repeat 336..365 CDD:275380 9/29 (31%)
LRR 378..>714 CDD:443914 97/406 (24%)
leucine-rich repeat 393..416 CDD:275380 3/23 (13%)
leucine-rich repeat 477..498 CDD:275380 5/20 (25%)
leucine-rich repeat 499..523 CDD:275380 8/23 (35%)
leucine-rich repeat 524..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..577 CDD:275380 12/50 (24%)
leucine-rich repeat 578..630 CDD:275380 20/95 (21%)
leucine-rich repeat 601..618 CDD:275380 8/34 (24%)
leucine-rich repeat 631..655 CDD:275380 5/23 (22%)
leucine-rich repeat 656..679 CDD:275380 5/22 (23%)
leucine-rich repeat 680..703 CDD:275380 8/22 (36%)
leucine-rich repeat 704..727 CDD:275380 5/22 (23%)
leucine-rich repeat 728..746 CDD:275380 3/17 (18%)
leucine-rich repeat 753..774 CDD:275380 7/20 (35%)
SEFIR 870..1013 CDD:474043
Blue background indicates that the domain is not in the aligned region.

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