Protein Alignment atk and Lgr6

DIOPT Version :10

• Sequence 1: NP_649228.1
• Gene: atk / 40266
• FlyBaseID: FBgn0036995
• Length: 1535
• Species: Drosophila melanogaster
• Sequence 2: NP_001405234.1
• Gene: Lgr6 / 329252
• MGIID: 2441805
• Length: 1004
• Species: Mus musculus
• Alignment Length: 622
• Identity: 158/622 - (25%)
• Similarity: 234/622 - (37%)
• Gaps: 218/622 - (35%)

  Fly   163 YLSVQTGALQELPSHLFRHLPKLQHIHITGGSGLTRLEAGLFDGLISLKNLDLSHNGLNWIHLRA 227
            ||.:....|.||...||.||..|:.:.:: |:.|:.:....|.||.|||.|.|..|.|..|...|
Mouse    70 YLDLSMNNLTELQPGLFHHLRFLEELRLS-GNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEA 133

  Fly   228 LSRLPNLVSLKLSHNQISDVGMVGRIVKDLEHLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDN 292
            |..||:|.|                          ||||.|||:::.:.||..|.:|..|.|:||
Mouse   134 LWELPSLQS--------------------------LRLDANLISLVPERSFEGLSSLRHLWLDDN 172

  Fly   293 RITELQYGAFLRTPQLKTIYLQNNLIRRIHPESLLQASGSGVEAVHMYNNEIGHV---------- 347
            .:||:...|....|.|:.:.|..|.||.| |:...|...|.| .:|::||.|.||
Mouse   173 ALTEIPVRALNNLPALQAMTLALNHIRHI-PDYAFQNLTSLV-VLHLHNNRIQHVGTHSFEGLHN 235

  Fly   348 -EALRALLDALPRLRYL-------------------------DMSGNLLSELPYGALRGHGTLEQ 386
             |.|...|...|. |:|                         |::.|.|.|.|. |:|..|.|::
Mouse   236 LETLVFFLFCSPE-RFLGEPAGEGRCGGGGAAARMKGGRNDRDLNYNELQEFPL-AIRTLGRLQE 298

  Fly   387 LHLNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWNLPGLKGLDLAQNQFARVDSQLLA 451
            |..::|:::.|...|.|..|.|:.:...:|      |:.|
Mouse   299 LGFHNNNIKAIPEKAFMGSPLLQTIHFYDN------PIQF------------------------- 332

  Fly   452 GLPSLRRLDLSENGLIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHLERLFEVDASYNQLKS 516
                             :..::|::...|.||::  |..|.|.               .:..||.
Mouse   333 -----------------VGRSAFQYLSKLHTLSL--NGATDIQ---------------EFPDLKG 363

  Fly   517 VIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLA 581
            ..:     :|.::|....|..||....:  |||.||:|:||.|:||:||
Mouse   364 TTS-----LEILTLTRAGIRLLPPGVCQ--QLPRLRILELSHNQIEELP---------------- 405

  Fly   582 QNELRQLKDTSFIGIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSR 646
                      |....|:||                        .:.|:.|:::.|..:.||....
Mouse   406 ----------SLHRCQKLE------------------------EIGLRHNRIKEIGADTFSQLGS 436

  Fly   647 LEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISV-GLGNLNNLRDIDLSYNQISRIQSD 710
            |:.||||.|.||:|.|.||.|.|||..|||:.|.|..:.: |||.|
Mouse   437 LQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGL------------------- 482

  Fly   711 VIGGWRNVVEIRLSNNLIVELQQGTFRNLPKLQYLDL 747
                    :.::|..||.:. |..:..:.|||:.|::
Mouse   483 --------MHLKLKGNLALS-QAFSKDSFPKLRILEV 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
atk	NP_649228.1	leucine-rich repeat	886..906	CDD:275380
		PCC	891..>936	CDD:188093
		leucine-rich repeat	69..89	CDD:275380
		leucine-rich repeat	90..113	CDD:275380
		LRR	93..530	CDD:443914	99/402 (25%)
		leucine-rich repeat	115..138	CDD:275380
		leucine-rich repeat	139..160	CDD:275380
		leucine-rich repeat	161..184	CDD:275380	9/20 (45%)
		leucine-rich repeat	185..209	CDD:275380	6/23 (26%)
		leucine-rich repeat	210..233	CDD:275380	10/22 (45%)
		leucine-rich repeat	234..259	CDD:275380	2/24 (8%)
		leucine-rich repeat	260..283	CDD:275380	10/22 (45%)
		leucine-rich repeat	284..307	CDD:275380	8/22 (36%)
		leucine-rich repeat	308..359	CDD:275380	19/61 (31%)
		leucine-rich repeat	334..348	CDD:275378	7/24 (29%)
		PLN00113	359..>824	CDD:215061	90/415 (22%)
		leucine-rich repeat	360..383	CDD:275380	9/47 (19%)
		leucine-rich repeat	384..407	CDD:275380	6/22 (27%)
		leucine-rich repeat	408..431	CDD:275380	4/22 (18%)
		leucine-rich repeat	432..455	CDD:275380	0/22 (0%)
		leucine-rich repeat	456..476	CDD:275380	1/19 (5%)
		leucine-rich repeat	480..501	CDD:275380	6/20 (30%)
		leucine-rich repeat	505..517	CDD:275378	2/11 (18%)
		leucine-rich repeat	525..550	CDD:275380	7/24 (29%)
		leucine-rich repeat	551..574	CDD:275380	10/22 (45%)
		leucine-rich repeat	575..598	CDD:275380	1/22 (5%)
		leucine-rich repeat	599..622	CDD:275380	2/22 (9%)
		leucine-rich repeat	623..646	CDD:275380	5/22 (23%)
		leucine-rich repeat	647..670	CDD:275380	13/22 (59%)
		leucine-rich repeat	671..693	CDD:275380	10/22 (45%)
		leucine-rich repeat	694..717	CDD:275380	0/22 (0%)
		leucine-rich repeat	718..741	CDD:275380	4/22 (18%)
		leucine-rich repeat	742..763	CDD:275380	2/6 (33%)
		leucine-rich repeat	766..789	CDD:275380
		leucine-rich repeat	790..813	CDD:275380
		leucine-rich repeat	814..835	CDD:275380
		leucine-rich repeat	838..861	CDD:275380
		leucine-rich repeat	862..885	CDD:275380
Lgr6	NP_001405234.1	LRR	<51..350	CDD:443914	93/360 (26%)
		leucine-rich repeat	70..91	CDD:275380	9/20 (45%)
		leucine-rich repeat	92..115	CDD:275380	6/23 (26%)
		leucine-rich repeat	116..139	CDD:275380	10/22 (45%)
		leucine-rich repeat	140..163	CDD:275380	12/48 (25%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..211	CDD:275380	8/23 (35%)
		leucine-rich repeat	212..235	CDD:275380	7/23 (30%)
		leucine-rich repeat	236..295	CDD:275380	13/60 (22%)
		LRR	277..>508	CDD:443914	87/381 (23%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		leucine-rich repeat	320..341	CDD:275380	5/68 (7%)
		leucine-rich repeat	344..385	CDD:275380	13/62 (21%)
		leucine-rich repeat	391..412	CDD:275380	11/46 (24%)
		leucine-rich repeat	413..436	CDD:275380	7/46 (15%)
		leucine-rich repeat	437..458	CDD:275380	12/20 (60%)
		leucine-rich repeat	461..481	CDD:275380	8/19 (42%)
		7tmA_LGR6	599..875	CDD:320484
		TM helix 1	600..626	CDD:320484
		TM helix 2	634..659	CDD:320484
		TM helix 3	679..709	CDD:320484
		TM helix 4	721..743	CDD:320484
		TM helix 5	765..794	CDD:320484
		TM helix 6	803..833	CDD:320484
		TM helix 7	843..868	CDD:320484