DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atk and Lrrc32

DIOPT Version :9

Sequence 1:	NP_001262113.1	Gene:	atk / 40266	FlyBaseID:	FBgn0036995	Length:	1535	Species:	Drosophila melanogaster
Sequence 2:	XP_006229808.1	Gene:	Lrrc32 / 293135	RGDID:	1309087	Length:	690	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	171/642 - (26%)
Similarity:	271/642 - (42%)	Gaps:	117/642 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 HPESLLQAS---GSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGT 383
            |..||||..   ...::|:::..|.:..:  |.:.|.....||:||:|.|.:|.|..|..:....
  Rat    64 HGLSLLQVPSVLSLDIQALYLSGNRLQSI--LVSPLSFYTALRHLDLSDNEISFLQPGVFQALPY 126

  Fly   384 LEQLHLNHNHL---RLIERDALMAMPALRELRMRNNSLSSDL-PLPFWNLPGLKGLDLAQNQFAR 444
            ||.|:|.||.|   ..:....|..:|.:..|.:..|||...| .......|.|:.|.||:|...|
  Rat   127 LEHLNLAHNRLAAGMALNSGGLGRLPLVVSLDLSGNSLHGSLVERLLGEAPRLRTLSLAENSLTR 191

  Fly   445 VDSQLLAGLPSLRRLDLSENGLIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHLERLFEVDA 509
            :......|:|::.:|||..|.|:::...:|...|.|..||:|.|.||.|.             |.
  Rat   192 LARHTFWGMPAMEQLDLHSNVLMDIEDGAFEALPQLTHLNLSRNSLTCIS-------------DF 243

  Fly   510 SYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAME 574
            |..||           :.:.|..|.|.:...|.....|. .|..|||.:|::...|    ..||.
  Rat   244 SLQQL-----------QVLDLSCNSIETFQTAPESQAQF-QLAWLDLRENKLLHFP----DLAMF 292

  Fly   575 LRVLSL-AQNELRQLKDTSFIGI-QRLELLH---------LQENQLGEADERALLPLAELRNLNL 628
            .|::.| ..|.|.||.    .|: |..|.||         |..|....|   ::.||::|.||:|
  Rat   293 PRLIYLNVSNNLIQLP----TGLPQDSEDLHAPSEGWSASLLSNPSRNA---SIHPLSQLLNLDL 350

  Fly   629 QSNKLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLEYLDLSGNALLDISVGLGNLNN 693
            ..|::|.:...|..:.:.|..|:||||.:||     |:.:|:                  |:|..
  Rat   351 SYNEIELVPAGFLEHLTSLRFLNLSRNCLRS-----FEARRA------------------GSLPC 392

  Fly   694 LRDIDLSYNQISRIQ--SDVIGGWRNVVEIRLSNNLIVELQQGTFRNLPKLQYLDLSSNEIR--- 753
            |..:|||:|.:..::  :.|:|..:.::   |.:|.:.||...||..|..||.|:|..|::.
  Rat   393 LVLLDLSHNVLEALELGTKVLGSLKTLL---LQDNTLRELPPYTFAGLASLQRLNLQGNQVSPCG 454

  Fly   754 -NVEPGALKGLDELQEFVLADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFL 817
             ..|||....:|                   |..:|:|...:...|.:..:...||.: ..|..|
  Rat   455 GQAEPGPPGCVD-------------------FSGIPTLHFLNMAGNSMETLRAGSFLH-TPLTEL 499

  Fly   818 NLSNNHFRNMEN---IGLRSMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNNQICRIQGSP 879
            :||.|...::..   :||.:  :||||:|..||: :|..:.|.....|..|.:..|::..:..
  Rat   500 DLSANPGLDVATGALVGLEA--SLEVLELQGNGL-VVLRVDLPCFRRLKRLNLAENRLSHLPA-- 559

  Fly   880 FETMPRLRVLSMRNNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQE 936
            :.....|.||.:|||....:.......:..::..|.:.|||:.| |...||:..|.:
  Rat   560 WTRAVSLEVLDLRNNSFSLLPGNAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQ 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atk	NP_001262113.1	leucine-rich repeat	69..89	CDD:275380
		leucine-rich repeat	90..113	CDD:275380
		leucine-rich repeat	115..138	CDD:275380
		leucine-rich repeat	139..160	CDD:275380
		leucine-rich repeat	161..184	CDD:275380
		LRR_8	183..244	CDD:290566
		leucine-rich repeat	185..209	CDD:275380
		LRR_4	209..247	CDD:289563
		leucine-rich repeat	210..233	CDD:275380
		leucine-rich repeat	234..259	CDD:275380
		LRR_RI	250..492	CDD:238064	54/176 (31%)
		LRR_8	259..318	CDD:290566
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..359	CDD:275380	9/39 (23%)
		leucine-rich repeat	334..348	CDD:275378	2/13 (15%)
		LRR_8	358..418	CDD:290566	20/62 (32%)
		leucine-rich repeat	360..383	CDD:275380	9/22 (41%)
		leucine-rich repeat	384..407	CDD:275380	8/25 (32%)
		LRR_8	406..466	CDD:290566	19/60 (32%)
		leucine-rich repeat	408..431	CDD:275380	5/23 (22%)
		leucine-rich repeat	432..455	CDD:275380	7/22 (32%)
		LRR_RI	447..705	CDD:238064	74/268 (28%)
		LRR_8	454..514	CDD:290566	18/59 (31%)
		leucine-rich repeat	456..476	CDD:275380	6/19 (32%)
		leucine-rich repeat	480..501	CDD:275380	8/20 (40%)
		leucine-rich repeat	505..517	CDD:275378	4/11 (36%)
		leucine-rich repeat	525..550	CDD:275380	5/24 (21%)
		LRR_8	549..609	CDD:290566	21/70 (30%)
		leucine-rich repeat	551..574	CDD:275380	7/22 (32%)
		leucine-rich repeat	575..598	CDD:275380	7/24 (29%)
		leucine-rich repeat	599..622	CDD:275380	8/31 (26%)
		LRR_8	622..681	CDD:290566	17/58 (29%)
		leucine-rich repeat	623..646	CDD:275380	7/22 (32%)
		LRR_RI	647..896	CDD:238064	66/257 (26%)
		leucine-rich repeat	647..670	CDD:275380	9/22 (41%)
		leucine-rich repeat	671..693	CDD:275380	2/21 (10%)
		leucine-rich repeat	694..717	CDD:275380	7/24 (29%)
		LRR_8	716..776	CDD:290566	16/63 (25%)
		leucine-rich repeat	718..741	CDD:275380	7/22 (32%)
		leucine-rich repeat	742..763	CDD:275380	8/24 (33%)
		LRR_8	765..824	CDD:290566	11/58 (19%)
		leucine-rich repeat	766..789	CDD:275380	1/22 (5%)
		leucine-rich repeat	790..813	CDD:275380	4/22 (18%)
		leucine-rich repeat	814..835	CDD:275380	7/23 (30%)
		leucine-rich repeat	838..861	CDD:275380	9/22 (41%)
		LRR_8	862..921	CDD:290566	12/58 (21%)
		leucine-rich repeat	862..885	CDD:275380	3/22 (14%)
		leucine-rich repeat	886..906	CDD:275380	6/19 (32%)
		TPKR_C2	919..>946	CDD:301599	7/18 (39%)
Lrrc32	XP_006229808.1	LRR_8	80..137	CDD:290566	19/58 (33%)
		LRR_RI	82..305	CDD:238064	70/253 (28%)
		leucine-rich repeat	82..102	CDD:275380	3/21 (14%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		leucine-rich repeat	127..153	CDD:275380	8/25 (32%)
		leucine-rich repeat	154..178	CDD:275380	5/23 (22%)
		LRR_8	177..237	CDD:290566	21/59 (36%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRR_8	225..283	CDD:290566	23/82 (28%)
		leucine-rich repeat	227..247	CDD:275380	10/32 (31%)
		leucine-rich repeat	248..272	CDD:275380	6/35 (17%)
		leucine-rich repeat	273..294	CDD:275380	8/24 (33%)
		LRR_8	343..403	CDD:290566	24/82 (29%)
		leucine-rich repeat	345..368	CDD:275380	7/22 (32%)
		LRR_RI	389..605	CDD:238064	60/244 (25%)
		LRR_8	393..450	CDD:290566	19/59 (32%)
		leucine-rich repeat	393..415	CDD:275380	6/21 (29%)
		leucine-rich repeat	416..439	CDD:275380	7/25 (28%)
		leucine-rich repeat	440..472	CDD:275380	10/50 (20%)
		leucine-rich repeat	473..494	CDD:275380	4/21 (19%)
		leucine-rich repeat	496..520	CDD:275380	7/25 (28%)
		leucine-rich repeat	521..543	CDD:275380	9/22 (41%)
		LRR_8	542..601	CDD:290566	12/60 (20%)
		leucine-rich repeat	544..565	CDD:275380	3/22 (14%)
		leucine-rich repeat	566..587	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138601at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920