DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and dma-1

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_492253.1 Gene:dma-1 / 187968 WormBaseID:WBGene00011345 Length:603 Species:Caenorhabditis elegans


Alignment Length:409 Identity:111/409 - (27%)
Similarity:177/409 - (43%) Gaps:69/409 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   541 AASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLHLQ 605
            |.|:.::||:|.:|||..|.||......|.|..:||||.|:.|.|..|....|..::.|..|.|.
 Worm   103 AMSRSIRLPSLEVLDLHSNNIEHATMSNFGGMPKLRVLDLSSNHLNILPTGVFTYLRALRSLSLS 167

  Fly   606 ENQLGEADERALLPLAELRNLNLQSN--KLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQ 668
            .|.:.:.....|..|..||.|.|..|  .:|.|.: .|::.|:|::|.|:...:.||...|.|..
 Worm   168 NNTISDLSTNLLRGLNSLRVLRLDRNPIPIEHINE-LFTDVSQLDELYLNHCNLSSIYSLALDRI 231

  Fly   669 RSLEYLDLSGNALLDI-SVGLGNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLSNNLI---- 728
            ..|..|.:.||.|..: :..|.:|..|..:|||:|.|..|.:..... .|:.::.||:||:    
 Worm   232 PQLRQLGIGGNNLKMVPTKELRSLPQLSVLDLSHNSIQEITACAFCN-TNISKLDLSHNLLGISK 295

  Fly   729 -VELQQGTFRNLPKLQYLDLSSNEIRNVEPGALK-GLDELQEFVLADNKLVELKDHVFEELPSLL 791
             ....:..||.:| |::||||.|.:.:.:...|. ..:||....|:.|.|...::.....|.||:
 Worm   296 DSPFNEDAFRTMP-LRHLDLSFNHMNDFDSKWLGWAQEELTSIALSGNFLKNFEESWTYTLKSLI 359

  Fly   792 ASHFQYNKLRYIS---PESFHNANSLVFLNLSNNHFRNM-ENIGLRSMRNLEVLDLSTNGVKLVS 852
            .....||.:::|.   |..:::   |:.||:|.|....: :||. ..:.|::..|::.|.....|
 Worm   360 HLELAYNHIKFIPVQLPSRYYH---LISLNISGNELTYLPDNIN-TLLPNVKTFDITANRFHTFS 420

  Fly   853 TMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMRNNQLRSIKERTFRNVRGNIAILDVD 917
            ...|..||                                                 |:..:.||
 Worm   421 HTDLAFLN-------------------------------------------------NVEQVYVD 436

  Fly   918 GNPIDCNCEMQWLSVWLQE 936
            |||.||:|.:|.|.|.:::
 Worm   437 GNPWDCSCAIQGLQVHMRD 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
LRR_8 183..244 CDD:290566
leucine-rich repeat 185..209 CDD:275380
LRR_4 209..247 CDD:289563
leucine-rich repeat 210..233 CDD:275380
leucine-rich repeat 234..259 CDD:275380
LRR_RI 250..492 CDD:238064
LRR_8 259..318 CDD:290566
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..359 CDD:275380
leucine-rich repeat 334..348 CDD:275378
LRR_8 358..418 CDD:290566
leucine-rich repeat 360..383 CDD:275380
leucine-rich repeat 384..407 CDD:275380
LRR_8 406..466 CDD:290566
leucine-rich repeat 408..431 CDD:275380
leucine-rich repeat 432..455 CDD:275380
LRR_RI 447..705 CDD:238064 56/166 (34%)
LRR_8 454..514 CDD:290566
leucine-rich repeat 456..476 CDD:275380
leucine-rich repeat 480..501 CDD:275380
leucine-rich repeat 505..517 CDD:275378
leucine-rich repeat 525..550 CDD:275380 3/8 (38%)
LRR_8 549..609 CDD:290566 23/59 (39%)
leucine-rich repeat 551..574 CDD:275380 9/22 (41%)
leucine-rich repeat 575..598 CDD:275380 9/22 (41%)
leucine-rich repeat 599..622 CDD:275380 6/22 (27%)
LRR_8 622..681 CDD:290566 20/60 (33%)
leucine-rich repeat 623..646 CDD:275380 8/24 (33%)
LRR_RI 647..896 CDD:238064 62/259 (24%)
leucine-rich repeat 647..670 CDD:275380 7/22 (32%)
leucine-rich repeat 671..693 CDD:275380 7/22 (32%)
leucine-rich repeat 694..717 CDD:275380 7/22 (32%)
LRR_8 716..776 CDD:290566 19/65 (29%)
leucine-rich repeat 718..741 CDD:275380 6/27 (22%)
leucine-rich repeat 742..763 CDD:275380 7/21 (33%)
LRR_8 765..824 CDD:290566 17/61 (28%)
leucine-rich repeat 766..789 CDD:275380 5/22 (23%)
leucine-rich repeat 790..813 CDD:275380 5/25 (20%)
leucine-rich repeat 814..835 CDD:275380 7/21 (33%)
leucine-rich repeat 838..861 CDD:275380 5/22 (23%)
LRR_8 862..921 CDD:290566 5/58 (9%)
leucine-rich repeat 862..885 CDD:275380 0/22 (0%)
leucine-rich repeat 886..906 CDD:275380 0/19 (0%)
TPKR_C2 919..>946 CDD:301599 8/18 (44%)
dma-1NP_492253.1 LRR_8 90..147 CDD:338972 19/43 (44%)
leucine-rich repeat 91..112 CDD:275380 3/8 (38%)
leucine-rich repeat 113..136 CDD:275380 9/22 (41%)
LRR 136..430 CDD:227223 86/349 (25%)
leucine-rich repeat 137..160 CDD:275380 9/22 (41%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 185..209 CDD:275380 8/24 (33%)
leucine-rich repeat 210..233 CDD:275380 7/22 (32%)
leucine-rich repeat 234..257 CDD:275380 7/22 (32%)
leucine-rich repeat 258..280 CDD:275380 7/22 (32%)
leucine-rich repeat 281..307 CDD:275380 6/25 (24%)
leucine-rich repeat 309..357 CDD:275380 13/47 (28%)
leucine-rich repeat 382..405 CDD:275380 7/23 (30%)
leucine-rich repeat 406..429 CDD:275380 6/71 (8%)
TPKR_C2 438..>478 CDD:387596 8/18 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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