DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and lron-1

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:NP_510424.4 Gene:lron-1 / 181553 WormBaseID:WBGene00008093 Length:607 Species:Caenorhabditis elegans


Alignment Length:759 Identity:176/759 - (23%)
Similarity:281/759 - (37%) Gaps:243/759 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MLLPIFLLLCIGINLIRAESCPPSQAILPCRC-SLRGKEIQIWC-SHSNLPQIMDGLKAVERNIK 64
            |.|.:|.||..|...   ..||..|...||.| |.|.:.:.|.| ..|:|..:::.|.    |..
 Worm     1 MRLLLFNLLIAGWVY---SQCPTLQLQEPCTCTSTRYEAVSINCDGGSSLDAVLESLS----NSP 58

  Fly    65 GRIDELVLENNQLPALPGRFFGSLQIVRLMLRHNSIERV-SNGWLNELENGLVEIFVVEPQLRSI 128
            ..||.|.:.|..:..:||..|...||.:|.||:|.:... .|.:...|||.|.|:.:....:..|
 Worm    59 QAIDSLTISNTPIEKMPGYAFQGFQIKKLFLRNNGLRSFHPNTFTGNLENSLEELEIRGNYIDGI 123

  Fly   129 PAESLNGMINMLAITIQSEELKHLPDFSGLLSLTYLSVQTGALQELPSHLFRHLPKLQHIHITGG 193
            |.                         ||:..|..|.:.:     ||.:|..::.....:.    
 Worm   124 PQ-------------------------SGVSILKQLKILS-----LPDNLIEYVQDNAFLS---- 154

  Fly   194 SGLTRLEAGLFDGLISLKNLDLSHNGLNWIHLRALSRLPNLVSLKLSHNQISDVGMVGRIVKDLE 258
                      :....||..||||.|.|..||                     ..|::|     ||
 Worm   155 ----------YHSRDSLLKLDLSANNLTAIH---------------------PTGLLG-----LE 183

  Fly   259 HLKKLRLDNNLITVIEDGSFVDLPNLSELHLNDNRITELQYGAFLRTPQLKTIYLQNNLIRRIHP 323
            :|.:|.||.||::.|...:..::|:|.:|.|..|||..:...: |..|.||::.|:.|.||.|..
 Worm   184 NLSQLSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISRNS-LPLPNLKSLSLEVNQIRLIPS 247

  Fly   324 ESLLQASGSGVEAVHMYNNEIGHVEALRALLDALPRLRYLDMSGNLLSELPYGALRGHGTLEQLH 388
            :|..:.                            |.|.||.:..|||:.:               
 Worm   248 DSFSET----------------------------PLLSYLYLGNNLLTSI--------------- 269

  Fly   389 LNHNHLRLIERDALMAMPALRELRMRNNSLSSDLPLPFWNLPGLKGLDLAQN------------- 440
                       ||.|                      |.::.|||.|.::.|             
 Worm   270 -----------DASM----------------------FLHIGGLKVLSMSNNKDITSIQANGKLS 301

  Fly   441 --QFARVDSQLLA--GLPSLRRLDLSENGLIELAPNSFRHNPLLETLNISSNELTKIHSSTLIHL 501
              || ::...:||  ..|||.||:|.:..:..:.|.|.:....::.:.:|.|::|:|...|..:|
 Worm   302 VQQF-KLCICILAFQHAPSLIRLELFDCSISRIEPKSLQKVQHIQVILLSRNQITRISHDTFSNL 365

  Fly   502 ERLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKDLQLPNLRMLDLSQNRIEQLPR 566
            ..|.|:|                     |.||.|.::...|..  |||.|..||||.||:|.||.
 Worm   366 PELSELD---------------------LSGNSINAVDDFAFS--QLPMLTSLDLSSNRLESLPS 407

  Fly   567 HG-FQGAME------LRVLSLAQNELRQLKDTSFIGIQRLELLHLQENQLGEADERAL-LPLAE- 622
            :. :...|:      .|.||:..|..|..||..::      ...|::|  |:....|. .|.|: 
 Worm   408 NVIYDSLMQKKTSPVQRKLSIQNNPWRCDKDLMWL------RKWLRDN--GDVTTAASNSPPAKC 464

  Fly   623 -----LRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQRSLE--YLDLSGNA 680
                 |..|:|:.      ||:...:.:....:|..:...:.::.:...:|...:  :.:::|.|
 Worm   465 WTPSNLSGLDLRQ------TDSKLPHKTTKPPVDQFQYKNQQVTNSNGTSQLGYQNPHTEVNGLA 523

  Fly   681 LLDISVG-----------LGNLNNLRDIDLSYNQISRIQSDVIG 713
            |:.:.:|           ||.|  :|.|.|||.  ::.:.:|.|
 Worm   524 LVGLILGIVLVVFVSCIILGYL--MRFIFLSYE--AKTKPNVFG 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380 5/19 (26%)
leucine-rich repeat 90..113 CDD:275380 7/23 (30%)
leucine-rich repeat 115..138 CDD:275380 4/22 (18%)
leucine-rich repeat 139..160 CDD:275380 2/20 (10%)
leucine-rich repeat 161..184 CDD:275380 5/22 (23%)
LRR_8 183..244 CDD:290566 10/60 (17%)
leucine-rich repeat 185..209 CDD:275380 0/23 (0%)
LRR_4 209..247 CDD:289563 10/37 (27%)
leucine-rich repeat 210..233 CDD:275380 9/22 (41%)
leucine-rich repeat 234..259 CDD:275380 3/24 (13%)
LRR_RI 250..492 CDD:238064 57/258 (22%)
LRR_8 259..318 CDD:290566 20/58 (34%)
leucine-rich repeat 260..283 CDD:275380 7/22 (32%)
leucine-rich repeat 284..307 CDD:275380 7/22 (32%)
leucine-rich repeat 308..359 CDD:275380 8/50 (16%)
leucine-rich repeat 334..348 CDD:275378 0/13 (0%)
LRR_8 358..418 CDD:290566 10/59 (17%)
leucine-rich repeat 360..383 CDD:275380 6/22 (27%)
leucine-rich repeat 384..407 CDD:275380 3/22 (14%)
LRR_8 406..466 CDD:290566 16/76 (21%)
leucine-rich repeat 408..431 CDD:275380 1/22 (5%)
leucine-rich repeat 432..455 CDD:275380 8/39 (21%)
LRR_RI 447..705 CDD:238064 70/286 (24%)
LRR_8 454..514 CDD:290566 17/59 (29%)
leucine-rich repeat 456..476 CDD:275380 6/19 (32%)
leucine-rich repeat 480..501 CDD:275380 5/20 (25%)
leucine-rich repeat 505..517 CDD:275378 2/11 (18%)
leucine-rich repeat 525..550 CDD:275380 7/24 (29%)
LRR_8 549..609 CDD:290566 21/66 (32%)
leucine-rich repeat 551..574 CDD:275380 10/23 (43%)
leucine-rich repeat 575..598 CDD:275380 7/22 (32%)
leucine-rich repeat 599..622 CDD:275380 5/23 (22%)
LRR_8 622..681 CDD:290566 8/66 (12%)
leucine-rich repeat 623..646 CDD:275380 5/22 (23%)
LRR_RI 647..896 CDD:238064 16/80 (20%)
leucine-rich repeat 647..670 CDD:275380 2/22 (9%)
leucine-rich repeat 671..693 CDD:275380 7/34 (21%)
leucine-rich repeat 694..717 CDD:275380 7/20 (35%)
LRR_8 716..776 CDD:290566
leucine-rich repeat 718..741 CDD:275380
leucine-rich repeat 742..763 CDD:275380
LRR_8 765..824 CDD:290566
leucine-rich repeat 766..789 CDD:275380
leucine-rich repeat 790..813 CDD:275380
leucine-rich repeat 814..835 CDD:275380
leucine-rich repeat 838..861 CDD:275380
LRR_8 862..921 CDD:290566
leucine-rich repeat 862..885 CDD:275380
leucine-rich repeat 886..906 CDD:275380
TPKR_C2 919..>946 CDD:301599
lron-1NP_510424.4 PRK15370 <58..>289 CDD:185268 81/377 (21%)
leucine-rich repeat 85..109 CDD:275380 7/23 (30%)
leucine-rich repeat 110..133 CDD:275380 7/47 (15%)
leucine-rich repeat 134..157 CDD:275380 4/41 (10%)
leucine-rich repeat 161..184 CDD:275380 12/48 (25%)
leucine-rich repeat 185..208 CDD:275380 7/22 (32%)
leucine-rich repeat 209..231 CDD:275380 7/22 (32%)
leucine-rich repeat 232..255 CDD:275380 8/50 (16%)
leucine-rich repeat 256..279 CDD:275380 10/70 (14%)
leucine-rich repeat 280..319 CDD:275380 8/39 (21%)
leucine-rich repeat 320..343 CDD:275380 6/22 (27%)
LRR_8 343..402 CDD:338972 23/81 (28%)
leucine-rich repeat 344..367 CDD:275380 6/22 (27%)
leucine-rich repeat 368..391 CDD:275380 10/45 (22%)
leucine-rich repeat 392..410 CDD:275380 10/17 (59%)
leucine-rich repeat 414..435 CDD:275378 5/20 (25%)
LRRCT 431..>472 CDD:214507 11/48 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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