DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and lrrc32.2

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:XP_031747547.1 Gene:lrrc32.2 / 100496842 XenbaseID:XB-GENE-6461207 Length:682 Species:Xenopus tropicalis


Alignment Length:679 Identity:178/679 - (26%)
Similarity:288/679 - (42%) Gaps:161/679 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 LPR-LRYLDMSGNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNSLSS 420
            ||| ::.||:|.||::::....:....:|:.|.|.:|.|..|:|.|.:|:..|..|.:..|.|..
 Frog    40 LPRSIKTLDLSHNLITKITVSPISHLHSLQSLSLGYNQLEEIDRGAFLAVTQLDTLNLAANQLHK 104

  Fly   421 DLPL---PFWNLPGLKGLDLAQNQFARVDSQL----LAGLPSLRRLDLSENGLIELAPNSFRHNP 478
            ....   .|.:||.||.|.||||   .:||::    |.|..||::||||.|.::.|:|.:|....
 Frog   105 HYQRHDGVFASLPNLKILSLAQN---HLDSKMVTFYLNGSRSLKKLDLSGNKMVTLSPGTFDGAL 166

  Fly   479 LLETLNISSNELTKIHSSTLIHLERLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSLPAAA- 542
            .|..|::::|::|.|...|...|:.|..::.:.|.::.:.:        ..|...|:.:|.:.| 
 Frog   167 HLTELDLANNDITGITEGTFDALQNLRTLNLAGNFIQCIAS--------FDLTQLQVLNLSSNAL 223

  Fly   543 ----SKDLQLP-NLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELL 602
                |.|.|.| .|..||||||.:::.|  ......:::.|:|:.|.|.::...|...::.:|..
 Frog   224 RFFYSNDSQTPYQLSTLDLSQNNLKRFP--FLPNIHKIQYLNLSGNNLVEMAPGSETTLENVESS 286

  Fly   603 HLQENQLG----EADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLI------ 657
            |..|...|    .|.|.:...|:.||:|:|..|.|.:...:|.||.:|||.|:|:.|.|      
 Frog   287 HWFEAAEGLDLFSAIEYSNYNLSHLRDLDLSHNHLTSFPSHFLSNATRLENLNLAHNCITYMREE 351

  Fly   658 --RSISPTAFD------TQRSLEYLDLSGNALLDISVGLGN-LNNLRDIDLSYNQ-ISRIQS--- 709
              .::|....|      |..:|:.|:|.||::..:...|.. |.|::.::|..|. |.|.||   
 Frog   352 PSSTVSSQVKDWTHIPVTLNALKVLNLEGNSIQTVPQWLFKFLPNIQHLNLKGNNVILRPQSHPK 416

  Fly   710 --------DVIGGWRNVVEIR---LSNNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGL 763
                    |:...:....:::   |.:|.|.:|....|.:.| |..||||.|....:|...::||
 Frog   417 MINGSSKDDICTNFSRAPKLKYLNLGHNYITQLPPRAFHHTP-LAVLDLSENLGLTLEESTMEGL 480

  Fly   764 DELQEFV-LADNKLVELKDHVFEELPSLLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNM 827
            :|..:|: |..|::.|.:    .:||.|                     .||.|||:|||..|  
 Frog   481 EESLQFLSLQGNQMNESQ----AKLPCL---------------------KSLQFLNMSNNKLR-- 518

  Fly   828 ENIGLRSMRNLEVLDLSTNGVKLVSTMPLKALNWLVELKMDNNQICRIQGSPFETMPRLRVLSMR 892
                                     .:|.             |..|          ..:.::.:|
 Frog   519 -------------------------ALPA-------------NLYC----------SHVDIVDLR 535

  Fly   893 NNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFPYPGPKCQDGRLLRSARM 957
            ||.||.:..:.......::..|.:.|||..| |.:.||.: ||      .||       :|...:
 Frog   536 NNDLRMLDNKAALAWASSLTHLYIKGNPFSC-CSLNWLKI-LQ------AGP-------VRIWDL 585

  Fly   958 ERSLCVGADIYGNERTDGNQLPLLNEHGD 986
            |.:.|    ||    .|.|.....|..||
 Frog   586 EEAHC----IY----LDNNSTGKANVTGD 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
LRR_8 183..244 CDD:290566
leucine-rich repeat 185..209 CDD:275380
LRR_4 209..247 CDD:289563
leucine-rich repeat 210..233 CDD:275380
leucine-rich repeat 234..259 CDD:275380
LRR_RI 250..492 CDD:238064 48/142 (34%)
LRR_8 259..318 CDD:290566
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..359 CDD:275380 1/1 (100%)
leucine-rich repeat 334..348 CDD:275378
LRR_8 358..418 CDD:290566 19/60 (32%)
leucine-rich repeat 360..383 CDD:275380 5/22 (23%)
leucine-rich repeat 384..407 CDD:275380 9/22 (41%)
LRR_8 406..466 CDD:290566 25/66 (38%)
leucine-rich repeat 408..431 CDD:275380 6/25 (24%)
leucine-rich repeat 432..455 CDD:275380 11/26 (42%)
LRR_RI 447..705 CDD:238064 79/287 (28%)
LRR_8 454..514 CDD:290566 19/59 (32%)
leucine-rich repeat 456..476 CDD:275380 9/19 (47%)
leucine-rich repeat 480..501 CDD:275380 6/20 (30%)
leucine-rich repeat 505..517 CDD:275378 1/11 (9%)
leucine-rich repeat 525..550 CDD:275380 8/30 (27%)
LRR_8 549..609 CDD:290566 17/60 (28%)
leucine-rich repeat 551..574 CDD:275380 8/22 (36%)
leucine-rich repeat 575..598 CDD:275380 5/22 (23%)
leucine-rich repeat 599..622 CDD:275380 7/26 (27%)
LRR_8 622..681 CDD:290566 24/72 (33%)
leucine-rich repeat 623..646 CDD:275380 9/22 (41%)
LRR_RI 647..896 CDD:238064 62/279 (22%)
leucine-rich repeat 647..670 CDD:275380 9/36 (25%)
leucine-rich repeat 671..693 CDD:275380 7/22 (32%)
leucine-rich repeat 694..717 CDD:275380 7/34 (21%)
LRR_8 716..776 CDD:290566 19/63 (30%)
leucine-rich repeat 718..741 CDD:275380 5/25 (20%)
leucine-rich repeat 742..763 CDD:275380 7/20 (35%)
LRR_8 765..824 CDD:290566 16/59 (27%)
leucine-rich repeat 766..789 CDD:275380 5/23 (22%)
leucine-rich repeat 790..813 CDD:275380 1/22 (5%)
leucine-rich repeat 814..835 CDD:275380 8/20 (40%)
leucine-rich repeat 838..861 CDD:275380 1/22 (5%)
LRR_8 862..921 CDD:290566 10/58 (17%)
leucine-rich repeat 862..885 CDD:275380 2/22 (9%)
leucine-rich repeat 886..906 CDD:275380 5/19 (26%)
TPKR_C2 919..>946 CDD:301599 10/26 (38%)
lrrc32.2XP_031747547.1 leucine-rich repeat 25..43 CDD:275380 2/2 (100%)
PLN00113 36..>497 CDD:215061 135/470 (29%)
leucine-rich repeat 45..67 CDD:275380 5/21 (24%)
leucine-rich repeat 68..91 CDD:275380 9/22 (41%)
leucine-rich repeat 92..118 CDD:275380 6/25 (24%)
leucine-rich repeat 119..143 CDD:275380 11/26 (42%)
leucine-rich repeat 144..167 CDD:275380 9/22 (41%)
leucine-rich repeat 168..191 CDD:275380 7/22 (32%)
leucine-rich repeat 192..212 CDD:275380 3/27 (11%)
leucine-rich repeat 213..236 CDD:275380 7/22 (32%)
leucine-rich repeat 237..258 CDD:275380 8/22 (36%)
leucine-rich repeat 259..280 CDD:275380 5/20 (25%)
leucine-rich repeat 335..372 CDD:275380 9/36 (25%)
leucine-rich repeat 373..396 CDD:275380 7/22 (32%)
leucine-rich repeat 436..456 CDD:275380 5/19 (26%)
leucine-rich repeat 459..483 CDD:275380 9/23 (39%)
leucine-rich repeat 484..506 CDD:275380 7/46 (15%)
leucine-rich repeat 507..528 CDD:275380 11/70 (16%)
leucine-rich repeat 529..553 CDD:275380 5/23 (22%)
leucine-rich repeat 554..573 CDD:275380 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138601at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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