DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atk and lrrc32

DIOPT Version :9

Sequence 1:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster
Sequence 2:XP_001920576.2 Gene:lrrc32 / 100148867 ZFINID:ZDB-GENE-090630-1 Length:659 Species:Danio rerio


Alignment Length:632 Identity:170/632 - (26%)
Similarity:266/632 - (42%) Gaps:133/632 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 ALRALLDALP-RLRYLDMSGNLLSELPYGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELR 412
            :||.:...|| .:|.||:|.|||..|....|....:|.:|.|:||.::.::       |.|    
Zfish    40 SLRRVPAPLPSSIRLLDLSQNLLQNLTLQDLPSRSSLRRLDLHHNQIQFLQ-------PGL---- 93

  Fly   413 MRNNSLSSDLPLPFWNLPGLKGLDLAQNQ---FARVDSQLLAGLPSLRRLDLSENGLI-ELAPNS 473
                         |.:|..|:.|||:.|.   :|.:.:. |..||:|||||||.|||. :::...
Zfish    94 -------------FRDLLHLEDLDLSGNALDLYAALHTP-LGPLPALRRLDLSGNGLFTDMSDYF 144

  Fly   474 FRHNPLLETLNISSNELTKIHSSTLIHLERLFEVDASYNQLKSVIAGLPRIVERISLKGNQITSL 538
            ....|.|..|::..|.:|||                                .|.:..|:|.   
Zfish   145 LSDAPALTNLSLDGNSITKI--------------------------------SRTTFNGSQA--- 174

  Fly   539 PAAASKDLQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNELRQLKDTSFIGIQRLELLH 603
                        |:.:||..|.|.::....|:...||..|.|:.|.:..:.|.:.:   :|..|:
Zfish   175 ------------LQNIDLHNNVIIEIEEGAFEFLTELSELDLSVNSISCITDFNLV---QLRTLN 224

  Fly   604 LQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRSISPTAFDTQ 668
            |..|.|.......:....:|::|:|:.|||  :........:||..|||||||:||::.:.  ..
Zfish   225 LSRNSLTNFQSLDMEDEFQLQHLDLRENKL--LYFPVLPQRNRLMYLDLSRNLLRSVNCSG--PL 285

  Fly   669 RSLEYLDLSGNAL--------LDISVGLGNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLSN 725
            ..||.|..||..|        |..:.....|..|..:|||:||:..:.|........:..:.:||
Zfish   286 EELESLRESGYLLTAHDKPLTLCANERQQELGRLLYLDLSFNQLKTLSSSFFSSMAALESLNISN 350

  Fly   726 NLIVELQQGTFRNLPKLQYLDLSSNEIRNV--EPGALKGLDELQEFVLADNKLVELKDHVFEELP 788
            |.   ||..:..:|..|:.||||.|.::|:  ..|||..|:.|   :|..|.|..|..|:|..||
Zfish   351 NC---LQSFSVDSLRSLKTLDLSFNNLQNLSFSGGALPALEVL---LLQGNALHLLDAHIFSSLP 409

  Fly   789 SLLASHFQYNKLR-----YISPESFHNAN--SLVFLNLSNNHFRNMENIGLRSMRNLEVLDLSTN 846
            |:.:.|.|.|.|.     .||....|.::  ||.:|.||.|...::.: |......|.:||||.|
Zfish   410 SIRSLHLQQNLLSICADPQISSGCVHLSDIPSLTYLYLSENSLSSIPD-GAFKGSPLLILDLSLN 473

  Fly   847 -GVKLVSTMPLKALNWLVELKMDNNQ--------------------ICRIQG-SPFETMPRLRVL 889
             ||.:.:.........|..|.:..||                    :.|:.| ||:.....:.:|
Zfish   474 PGVDITAASLSGVETSLTHLSLRGNQLHSLSIDFRVFQKLRSLDVSVNRLSGVSPWSEDSSVEIL 538

  Fly   890 SMRNNQLRSIKERTFRNVRGNIAILDVDGNPIDCNCEMQWLSVWLQE 936
            :::||::.::....   ::|.:..|.|..||:.|....|.|.:..||
Zfish   539 NLQNNRVEALGSAL---LQGRLRTLYVGWNPLSCCRNPQLLDLLQQE 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
LRR_8 183..244 CDD:290566
leucine-rich repeat 185..209 CDD:275380
LRR_4 209..247 CDD:289563
leucine-rich repeat 210..233 CDD:275380
leucine-rich repeat 234..259 CDD:275380
LRR_RI 250..492 CDD:238064 45/147 (31%)
LRR_8 259..318 CDD:290566
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..359 CDD:275380 4/10 (40%)
leucine-rich repeat 334..348 CDD:275378
LRR_8 358..418 CDD:290566 17/60 (28%)
leucine-rich repeat 360..383 CDD:275380 9/22 (41%)
leucine-rich repeat 384..407 CDD:275380 5/22 (23%)
LRR_8 406..466 CDD:290566 21/62 (34%)
leucine-rich repeat 408..431 CDD:275380 3/22 (14%)
leucine-rich repeat 432..455 CDD:275380 8/25 (32%)
LRR_RI 447..705 CDD:238064 71/266 (27%)
LRR_8 454..514 CDD:290566 18/60 (30%)
leucine-rich repeat 456..476 CDD:275380 10/20 (50%)
leucine-rich repeat 480..501 CDD:275380 6/20 (30%)
leucine-rich repeat 505..517 CDD:275378 0/11 (0%)
leucine-rich repeat 525..550 CDD:275380 3/24 (13%)
LRR_8 549..609 CDD:290566 16/59 (27%)
leucine-rich repeat 551..574 CDD:275380 6/22 (27%)
leucine-rich repeat 575..598 CDD:275380 5/22 (23%)
leucine-rich repeat 599..622 CDD:275380 5/22 (23%)
LRR_8 622..681 CDD:290566 22/58 (38%)
leucine-rich repeat 623..646 CDD:275380 6/22 (27%)
LRR_RI 647..896 CDD:238064 85/287 (30%)
leucine-rich repeat 647..670 CDD:275380 10/22 (45%)
leucine-rich repeat 671..693 CDD:275380 8/29 (28%)
leucine-rich repeat 694..717 CDD:275380 7/22 (32%)
LRR_8 716..776 CDD:290566 20/61 (33%)
leucine-rich repeat 718..741 CDD:275380 6/22 (27%)
leucine-rich repeat 742..763 CDD:275380 10/22 (45%)
LRR_8 765..824 CDD:290566 23/65 (35%)
leucine-rich repeat 766..789 CDD:275380 8/22 (36%)
leucine-rich repeat 790..813 CDD:275380 7/29 (24%)
leucine-rich repeat 814..835 CDD:275380 6/20 (30%)
leucine-rich repeat 838..861 CDD:275380 8/23 (35%)
LRR_8 862..921 CDD:290566 15/79 (19%)
leucine-rich repeat 862..885 CDD:275380 8/43 (19%)
leucine-rich repeat 886..906 CDD:275380 3/19 (16%)
TPKR_C2 919..>946 CDD:301599 7/18 (39%)
lrrc32XP_001920576.2 LRR_RI 33..276 CDD:238064 82/312 (26%)
leucine-rich repeat 55..75 CDD:275380 8/19 (42%)
leucine-rich repeat 76..125 CDD:275380 17/73 (23%)
leucine-rich repeat 100..122 CDD:275380 7/22 (32%)
leucine-rich repeat 126..150 CDD:275380 10/23 (43%)
LRR_8 149..209 CDD:290566 21/106 (20%)
leucine-rich repeat 151..174 CDD:275380 8/54 (15%)
leucine-rich repeat 175..198 CDD:275380 6/22 (27%)
LRR_RI 198..453 CDD:238064 83/267 (31%)
leucine-rich repeat 199..219 CDD:275380 5/22 (23%)
leucine-rich repeat 220..243 CDD:275380 5/22 (23%)
leucine-rich repeat 266..318 CDD:275380 18/53 (34%)
leucine-rich repeat 288..310 CDD:275380 7/21 (33%)
LRR_8 318..374 CDD:290566 19/58 (33%)
leucine-rich repeat 319..342 CDD:275380 7/22 (32%)
leucine-rich repeat 343..363 CDD:275380 6/22 (27%)
LRR_8 362..421 CDD:290566 24/61 (39%)
leucine-rich repeat 387..410 CDD:275380 9/25 (36%)
leucine-rich repeat 411..441 CDD:275380 7/29 (24%)
leucine-rich repeat 442..463 CDD:275380 6/21 (29%)
leucine-rich repeat 465..489 CDD:275380 8/23 (35%)
leucine-rich repeat 490..512 CDD:275380 4/21 (19%)
leucine-rich repeat 513..534 CDD:275380 4/20 (20%)
leucine-rich repeat 535..555 CDD:275380 3/22 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138601at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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