DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hpd and hpda

DIOPT Version :9

Sequence 1:	NP_730536.1	Gene:	Hpd / 40263	FlyBaseID:	FBgn0036992	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	XP_005171786.1	Gene:	hpda / 394142	ZFINID:	ZDB-GENE-040426-986	Length:	397	Species:	Danio rerio

Alignment Length:	383	Identity:	249/383 - (65%)
Similarity:	302/383 - (78%)	Gaps:	4/383 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYTDKGTKPEAGKFLSFDHLTFYVGNAKQAASYYTTRLGFEPLGYQGLETGERRFAKHAVRQN 65
            ||||||||.|||.||||:|.|:.|:||||||||.:|..:.|||||.|:|||||.|....|||:|:
Zfish     1 MTSYTDKGEKPERGKFLNFHHIKFWVGNAKQAAVFYCDKFGFEPLAYKGLETGSREVVSHAVKQD 65

  Fly    66 KIVFVFVSAYTPDDEEHGLHLMRHGDGVKDVAFEVEDLNAIFTLAVSRGAEVVRDIWEESDDQGF 130
            ||:|||.||..|.:||.|.||::||||||||||.|||.:.:...|..|||.|:::.|.|.|..|.
Zfish    66 KIIFVFESALNPGNEEMGEHLIKHGDGVKDVAFLVEDCDFLVKKAKERGAAVLKEPWVEQDAGGK 130

  Fly   131 VRFATIKTYGDTTHTFVERNG-YAGDFLPGFQRSP--KDVLLNGLPSTKLNFIDHVVGNQPDLQM 192
            |::|.::|||||||||||..| |.|.||||: :.|  :|.||..|||..|:||||:||||||.:|
Zfish   131 VKYAIVQTYGDTTHTFVEYLGPYKGLFLPGY-KEPLFRDPLLPKLPSGHLSFIDHIVGNQPDDEM 194

  Fly   193 ESVASWYERILQFHRFWSVDDSQIHTEYSALRSIVMANYEETVKMPINEPANGKKKSQIQEYVEY 257
            ..|:.||::.|.||||||:||.|||||||||||||:.|||||:||||||||.||||||||||::|
Zfish   195 VPVSDWYQKCLLFHRFWSIDDKQIHTEYSALRSIVVTNYEETIKMPINEPAMGKKKSQIQEYIDY 259

  Fly   258 YGGGGVQHIALNTDDIIEAVSNLKARGTEFLTIPSSYYEILQEQLSHSRTKIKEDMEVLKKLNIL 322
            .||.|||||||||.:||:|:.||:|||.|||:.|.:|||.|:|:|..::.|:|||::.|::|.||
Zfish   260 NGGPGVQHIALNTSNIIQAIVNLRARGLEFLSAPDNYYESLREKLKTAKIKVKEDLKTLQELKIL 324

  Fly   323 IDFDENGYLLQIFTKNCQDRPTLFLEVIQRYNHNGFGAGNFKSLFTAIEIEQAKRGNL 380
            :|||:.|||||||||..|||||||||||||.||.|||||||||||.|||.:|..||||
Zfish   325 VDFDDKGYLLQIFTKPVQDRPTLFLEVIQRNNHFGFGAGNFKSLFEAIEKDQDARGNL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hpd	NP_730536.1	4HPPD	17..380	CDD:273528	233/365 (64%)
hpda	XP_005171786.1	4HPPD	19..382	CDD:273528	232/363 (64%)
		HPPD_N_like	19..163	CDD:176690	83/144 (58%)
		HPPD_C_like	179..374	CDD:176673	138/194 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586799
Domainoid	1	1.000	231	1.000	Domainoid score	I2365
eggNOG	1	0.900	-	-		E1_COG3185
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1307
OMA	1	1.010	-	-		QHG63570
OrthoDB	1	1.010	-	-		D1087836at2759
OrthoFinder	1	1.000	-	-		FOG0004104
OrthoInspector	1	1.000	-	-		otm24598
orthoMCL	1	0.900	-	-		OOG6_102248
Panther	1	1.100	-	-	LDO	PTHR11959
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2577
SonicParanoid	1	1.000	-	-		X2845
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800