DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hpd and HPD

DIOPT Version :9

Sequence 1:	NP_730536.1	Gene:	Hpd / 40263	FlyBaseID:	FBgn0036992	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_002141.2	Gene:	HPD / 3242	HGNCID:	5147	Length:	393	Species:	Homo sapiens

Alignment Length:	382	Identity:	238/382 - (62%)
Similarity:	299/382 - (78%)	Gaps:	3/382 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYTDKGTKPEAGKFLSFDHLTFYVGNAKQAASYYTTRLGFEPLGYQGLETGERRFAKHAVRQN 65
            ||:|:|||.|||.|:||.|..:||:|||||||.|:|.:::|||||.|:|||||.|....|.::|.
Human     1 MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQATSFYCSKMGFEPLAYRGLETGSREVVSHVIKQG 65

  Fly    66 KIVFVFVSAYTPDDEEHGLHLMRHGDGVKDVAFEVEDLNAIFTLAVSRGAEVVRDIWEESDDQGF 130
            |||||..||..|.::|.|.||::|||||||:||||||.:.|...|..|||:::|:.|.|.|..|.
Human    66 KIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGK 130

  Fly   131 VRFATIKTYGDTTHTFVERNGYAGDFLPGFQRSP--KDVLLNGLPSTKLNFIDHVVGNQPDLQME 193
            |:||.::||||||||.||:..|.|.||||:: :|  .|.||..||...|..|||:||||||.:|.
Human   131 VKFAVLQTYGDTTHTLVEKMNYIGQFLPGYE-APAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMV 194

  Fly   194 SVASWYERILQFHRFWSVDDSQIHTEYSALRSIVMANYEETVKMPINEPANGKKKSQIQEYVEYY 258
            |.:.||.:.|||||||||||:|:|||||:|||||:|||||::||||||||.|||||||||||:|.
Human   195 SASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYN 259

  Fly   259 GGGGVQHIALNTDDIIEAVSNLKARGTEFLTIPSSYYEILQEQLSHSRTKIKEDMEVLKKLNILI 323
            ||.|||||||.|:|||.|:.:|:.||.|||::||:||:.|:|:|..::.|:||:::.|::|.||:
Human   260 GGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILV 324

  Fly   324 DFDENGYLLQIFTKNCQDRPTLFLEVIQRYNHNGFGAGNFKSLFTAIEIEQAKRGNL 380
            |:||.|||||||||..|||||||||||||:||.|||||||.|||.|.|.||..||||
Human   325 DYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hpd	NP_730536.1	4HPPD	17..380	CDD:273528	225/364 (62%)
HPD	NP_002141.2	4HPPD	19..381	CDD:273528	224/362 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152306
Domainoid	1	1.000	225	1.000	Domainoid score	I2555
eggNOG	1	0.900	-	-		E1_COG3185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1620
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1405
Isobase	1	0.950	-	0	Normalized mean entropy	S2226
OMA	1	1.010	-	-		QHG63570
OrthoDB	1	1.010	-	-		D1087836at2759
OrthoFinder	1	1.000	-	-		FOG0004104
OrthoInspector	1	1.000	-	-		oto88438
orthoMCL	1	0.900	-	-		OOG6_102248
Panther	1	1.100	-	-	O	PTHR11959
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2577
SonicParanoid	1	1.000	-	-		X2845
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750