DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hpd and C31H2.4

DIOPT Version :9

Sequence 1:	NP_730536.1	Gene:	Hpd / 40263	FlyBaseID:	FBgn0036992	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_508875.1	Gene:	C31H2.4 / 183101	WormBaseID:	WBGene00016294	Length:	364	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	163/381 - (42%)
Similarity:	232/381 - (60%)	Gaps:	33/381 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GKFLSFDHLTFYVGNAKQAASYYTTRLGFEPLGYQGLETGERRFAKH--------AVRQNKIVFV 70
            |...:..|:.|.|.||.|:|.:|.:..|||            :||:.        |:| |....|
Worm     2 GSISAIHHIEFIVSNALQSAYWYCSGFGFE------------KFAEKITDESTSIALR-NGTARV 53

  Fly    71 FVSAYTPD----DEEHGLHLMRHGDGVKDVAFEVEDLNAIFTLAVSRGAEVVRDIWEESDDQGFV 131
            .:::|...    |:     |::|||.:|||:|.|::|:|:....|....:|::.. |.|...|.|
Worm    54 IITSYNSQNIYTDQ-----LIKHGDFIKDVSFRVDNLDAVLQNLVENDIKVIQQS-EVSTKDGLV 112

  Fly   132 RFATIKTY-GDTTHTFVERNGYAGDFLPGFQRSPKDVLLNGLPSTKLNFIDHVVGNQPDLQMESV 195
            |.||:.:. ||.|||..|...:.|:|||.|.......|...:.......:||||.|.|..:||:.
Worm   113 RTATLLSEGGDVTHTLFELGEFKGNFLPFFTPISNFELFENIEKMPAILMDHVVQNYPIGEMEAA 177

  Fly   196 ASWYERILQFHRFWSVDDSQIHTEYSALRSIVMANYEETVKMPINEPANGKK-KSQIQEYVEYYG 259
            |.||.:.::..|||||||....:|:||:.:.::.|.:.||::.:.|...|:| ||||:|::.|:|
Worm   178 ADWYFKTMRLKRFWSVDDKVATSEFSAMTAWLLVNDDHTVQVTLAEGVKGRKGKSQIEEFINYHG 242

  Fly   260 GGGVQHIALNTDDIIEAVSNLKARGTEFLTIPSSYYEILQEQLSHSRTKIKEDMEVLKKLNILID 324
            |.||||.||..:|||.||..:|:|..|||||||.||:.|:|:||.:...:|||::::::||||:|
Worm   243 GSGVQHFALLVEDIISAVQIMKSRSVEFLTIPSQYYDNLEERLSKTNLIVKEDLKMIRELNILMD 307

  Fly   325 FDENGYLLQIFTKNCQDRPTLFLEVIQRYNHNGFGAGNFKSLFTAIEIEQAKRGNL 380
            |||||||||||:|..|||||||:|:|||.|..||||||||:||.|:|.||.|||.|
Worm   308 FDENGYLLQIFSKPLQDRPTLFIEIIQRANFKGFGAGNFKALFDAVEREQEKRGTL 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hpd	NP_730536.1	4HPPD	17..380	CDD:273528	161/376 (43%)
C31H2.4	NP_508875.1	4HPPD	5..363	CDD:273528	161/376 (43%)
		HPPD_N_like	7..144	CDD:176690	50/155 (32%)
		HPPD_C_like	162..355	CDD:176673	104/192 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3185
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2226
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087836at2759
OrthoFinder	1	1.000	-	-		FOG0004104
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11959
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2845
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.830