DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hpd and Hpd

DIOPT Version :9

Sequence 1:	NP_730536.1	Gene:	Hpd / 40263	FlyBaseID:	FBgn0036992	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_032303.1	Gene:	Hpd / 15445	MGIID:	96213	Length:	393	Species:	Mus musculus

Alignment Length:	382	Identity:	243/382 - (63%)
Similarity:	300/382 - (78%)	Gaps:	3/382 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSYTDKGTKPEAGKFLSFDHLTFYVGNAKQAASYYTTRLGFEPLGYQGLETGERRFAKHAVRQN 65
            ||:|.:||.|||.|:||.|..:||:|||||||||:|..::|||||.|:|||||.|....|.::|.
Mouse     1 MTTYNNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYRGLETGSREVVSHVIKQG 65

  Fly    66 KIVFVFVSAYTPDDEEHGLHLMRHGDGVKDVAFEVEDLNAIFTLAVSRGAEVVRDIWEESDDQGF 130
            |||||..||..|.::|.|.||::|||||||:||||||.:.|...|..|||::||:.|.|.|..|.
Mouse    66 KIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDHIVQKARERGAKIVREPWVEQDKFGK 130

  Fly   131 VRFATIKTYGDTTHTFVERNGYAGDFLPGFQRSP--KDVLLNGLPSTKLNFIDHVVGNQPDLQME 193
            |:||.::||||||||.||:..|.|.|||||: :|  ||.||..||...|..|||:||||||.:|:
Mouse   131 VKFAVLQTYGDTTHTLVEKINYTGRFLPGFE-APTYKDTLLPKLPRCNLEIIDHIVGNQPDQEMQ 194

  Fly   194 SVASWYERILQFHRFWSVDDSQIHTEYSALRSIVMANYEETVKMPINEPANGKKKSQIQEYVEYY 258
            |.:.||.:.|||||||||||:|:|||||:|||||:.||||::||||||||.|:|||||||||:|.
Mouse   195 SASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVTNYEESIKMPINEPAPGRKKSQIQEYVDYN 259

  Fly   259 GGGGVQHIALNTDDIIEAVSNLKARGTEFLTIPSSYYEILQEQLSHSRTKIKEDMEVLKKLNILI 323
            ||.|||||||.|:|||.|:.:|:.||||||..|||||::|:|.|..::.::||.|:||::|:||:
Mouse   260 GGAGVQHIALKTEDIITAIRHLRERGTEFLAAPSSYYKLLRENLKSAKIQVKESMDVLEELHILV 324

  Fly   324 DFDENGYLLQIFTKNCQDRPTLFLEVIQRYNHNGFGAGNFKSLFTAIEIEQAKRGNL 380
            |:||.|||||||||..|||||||||||||:||.|||||||.|||.|.|.|||.||||
Mouse   325 DYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQALRGNL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hpd	NP_730536.1	4HPPD	17..380	CDD:273528	231/364 (63%)
Hpd	NP_032303.1	4HPPD	19..381	CDD:273528	232/364 (64%)
		HPPD_N_like	19..162	CDD:176690	83/142 (58%)
		HPPD_C_like	178..373	CDD:176673	134/194 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842373
Domainoid	1	1.000	229	1.000	Domainoid score	I2473
eggNOG	1	0.900	-	-		E1_COG3185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1620
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1342
Isobase	1	0.950	-	0	Normalized mean entropy	S2226
OMA	1	1.010	-	-		QHG63570
OrthoDB	1	1.010	-	-		D1087836at2759
OrthoFinder	1	1.000	-	-		FOG0004104
OrthoInspector	1	1.000	-	-		oto92009
orthoMCL	1	0.900	-	-		OOG6_102248
Panther	1	1.100	-	-	O	PTHR11959
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2577
SonicParanoid	1	1.000	-	-		X2845
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750