DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psn and Psen2

DIOPT Version :9

Sequence 1:	NP_001262111.1	Gene:	Psn / 40260	FlyBaseID:	FBgn0284421	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_112349.2	Gene:	Psen2 / 81751	RGDID:	621060	Length:	448	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	247/550 - (44%)
Similarity:	317/550 - (57%)	Gaps:	128/550 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LASEDDANVGSQIGAAERLERPPRRQQQRNNYG------------SSNQD----QPDAAILAVPN 62
            :||:.:..|..:..:....|.|..|..|.:..|            ..|:|    .||
  Rat     5 MASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPD-------- 61

  Fly    63 VVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISF 127
               ...|...|.|.:|            :|||..|||||:|||.|||||:|||:||||||.|:.|
  Rat    62 ---HYACSGVPGRPSG------------LEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111

  Fly   128 YNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSS 192
            |...:..|:||||.|.:|....:..:::.|:||::||:||||..|:||||.|||:.||||||:||
  Rat   112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSS 176

  Fly   193 FMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMAL 257
            .||||:|||:||.|:.:.||:.|||||..|.:||||.|||:.|||:|||.|||.|||.::|||||
  Rat   177 LMLLFLFTYIYLGEVFKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMAL 241

  Fly   258 VFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTV 322
            |||||||||:||.:|.|||::||:|||.|:||||:||||||||||.|||||||||.:|:.:
  Rat   242 VFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV---- 302

  Fly   323 TPQQSQATASSSPSSSNSTTTTRATQNSLA---SPEAAAASGQRTGN-SHPRQNQRDDGSVLATE 383
                  ..|...|||          |.:|.   .||....|....|. |:|...:
  Rat   303 ------GMAKLDPSS----------QGALQLPYDPEMEEDSYDSFGEPSYPEAFE---------- 341

  Fly   384 GMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPD 448
                          |...|:..|                                       .|:
  Rat   342 --------------APQPGYPGE---------------------------------------EPE 353

  Fly   449 GQEERGIKLGLGDFIFYSVLVGKASS--YGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPI 511
            .:||||:|||||||||||||||||::  .|||:||:|||:||||||||||||||:::||||||||
  Rat   354 EEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLACFIAILIGLCLTLLLLAVFKKALPALPI 418

  Fly   512 SITFGLIFCFATSAVVKPFMEDLSAKQVFI 541
            ||||||||.|:|..:|:|||:.|::.|::|
  Rat   419 SITFGLIFYFSTDNLVRPFMDTLASHQLYI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	222/438 (51%)
Psen2	NP_112349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		12/67 (18%)
		Presenilin	82..438	CDD:395857	222/438 (51%)
		PAL	414..416		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H386
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1606
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm45642
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	LDO	PTHR10202
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810