Protein Alignment Psn and psen2

DIOPT Version :9

• Sequence 1: NP_001262111.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_571589.2
• Gene: psen2 / 58026
• ZFINID: ZDB-GENE-000330-9
• Length: 441
• Species: Danio rerio
• Alignment Length: 536
• Identity: 251/536 - (46%)
• Similarity: 326/536 - (60%)
• Gaps: 109/536 - (20%)

  Fly    15 ASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGG 79
            :.||..|           ||....|.:.....|.|||.    .:::|.....:..|:..|| :..
Zfish     6 SEEDSYN-----------ERSALVQSESPTVPSYNQDN----AMSLPQDTDSKRSGAVRSR-SAS 54

  Fly    80 GGGSGGPPTNEM-------EEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFY-NSTDVYLL 136
            |.|..||...|.       |||..|||||:|||.||:||:|||:||||||.|:||| ..:...|:
Zfish    55 GSGDAGPVDRERADTPDGEEEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTEKSGQRLI 119

  Fly   137 YTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTY 201
            ||||.|.......:..:::.|:|:::||:|.||.:|::|||.|||:.|||||||||.||||.|::
Zfish   120 YTPFEEDPNSVGQRLLNSVLNTLVMISVIVFMTIILVLLYKYRCYKFIHGWLILSSLMLLFWFSF 184

  Fly   202 LYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEW 266
            :||.|:.:.||:.|||||.::|:||||||||:.|||:|||||||.|||.::|||||:||||||||
Zfish   185 MYLGEVFKTYNVAMDYPTLVMIIWNFGVVGMICIHWKGPLRLQQAYLIVISALMALIFIKYLPEW 249

  Fly   267 TAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATA 331
            :||.:|.||||:||||||.|:||||:||||||||||.|||||||||.:|:.:
Zfish   250 SAWVILGAISIYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWMV------------- 301

  Fly   332 SSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRG 396
              ..:.||             :|::|   |:|         :|..|.|...||:
Zfish   302 --GMADSN-------------NPDSA---GER---------RRSGGGVRTQEGV----------- 328

  Fly   397 NAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGD 461
                                  :.|..:.|:|..|.|.|           .|.:|:||:||||||
Zfish   329 ----------------------ESEDDAPQAGRRQYSAE-----------EDLEEDRGVKLGLGD 360

  Fly   462 FIFYSVLVGKASSY-GDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSA 525
            |||||||||||::. |||.||:|||||||||||||||||||::||||||||||||||:|.|:|..
Zfish   361 FIFYSVLVGKAAATGGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFSTDN 425

  Fly   526 VVKPFMEDLSAKQVFI 541
            :|:|||:.|:|.|.:|
Zfish   426 LVRPFMDSLAAHQYYI 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	222/434 (51%)
psen2	NP_571589.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..74		19/83 (23%)
		Presenilin	80..431	CDD:279427	222/434 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	308..346		15/93 (16%)
		PAL	407..409		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H386
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1692
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm24389
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	LDO	PTHR10202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2736
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800