Protein Alignment Psn and PSEN2

DIOPT Version :10

• Sequence 1: NP_524184.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_000438.2
• Gene: PSEN2 / 5664
• HGNCID: 9509
• Length: 448
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 249/535 - (46%)
• Similarity: 315/535 - (58%)
• Gaps: 118/535 - (22%)

  Fly     9 SCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRP 73
            ||..|....:|.            |...:.:.|.|.  ...::.||           |..|...|
Human    30 SCQEGRQGPEDG------------ENTAQWRSQENE--EDGEEDPD-----------RYVCSGVP 69

  Fly    74 SRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYT 138
            .|          ||  .:|||..|||||:|||.|||||:|||:||||||.|:.||...:..|:||
Human    70 GR----------PP--GLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYT 122

  Fly   139 PFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLY 203
            ||.|.:|....:..:::.|:||::||:||||..|:||||.|||:.||||||:||.||||:|||:|
Human   123 PFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIY 187

  Fly   204 LEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTA 268
            |.|:|:.||:.|||||.||.:||||.|||:.|||:|||.|||.|||.::||||||||||||||:|
Human   188 LGEVLKTYNVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSA 252

  Fly   269 WAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASS 333
            |.:|.|||::||:|||.|:||||:||||||||||.|||||||||.:|:.:          ..|..
Human   253 WVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV----------GMAKL 307

  Fly   334 SPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNA 398
            .|||          |.:|..|             :..:.:.|..........|.| |:..|
Human   308 DPSS----------QGALQLP-------------YDPEMEEDSYDSFGEPSYPEV-FEPPL---- 344

  Fly   399 EAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFI 463
              .|:..|   .|.|                                    :||||:||||||||
Human   345 --TGYPGE---ELEE------------------------------------EEERGVKLGLGDFI 368

  Fly   464 FYSVLVGKASS--YGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAV 526
            |||||||||::  .|||.||:||||||||||||||||||:::||||||||||||||||.|:|..:
Human   369 FYSVLVGKAAATGSGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNL 433

  Fly   527 VKPFMEDLSAKQVFI 541
            |:|||:.|::.|::|
Human   434 VRPFMDTLASHQLYI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_524184.1	Presenilin	98..531	CDD:460052	225/434 (52%)
PSEN2	NP_000438.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		11/64 (17%)
		Presenilin	82..438	CDD:460052	225/434 (52%)
		PAL	414..416		1/1 (100%)