DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psn and PSEN1

DIOPT Version :9

Sequence 1:	NP_001262111.1	Gene:	Psn / 40260	FlyBaseID:	FBgn0284421	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_000012.1	Gene:	PSEN1 / 5663	HGNCID:	9508	Length:	467	Species:	Homo sapiens

Alignment Length:	528	Identity:	252/528 - (47%)
Similarity:	325/528 - (61%)	Gaps:	79/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGG 80
            |||     :.:....|.:...|.:|:.|:..|....:|.:              ..||.    |.
Human    17 SED-----NHLSNTVRSQNDNRERQEHNDRRSLGHPEPLS--------------NGRPQ----GN 58

  Fly    81 GGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSP 145
            .........|.:||..|||||:|||.|||||:|||:||||||.|:|||...|..|:||||.|.:.
Human    59 SRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTE 123

  Fly   146 EPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRA 210
            ....:...::.|:.|::||:||||.||:||||.|||::||.|||:||.:|||.|:::||.|:.:.
Human   124 TVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKT 188

  Fly   211 YNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAI 275
            ||:.:||.|..|::||||||||:||||:|||||||.|||.::|||||||||||||||||.:||.|
Human   189 YNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVI 253

  Fly   276 SIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNS 340
            |::||:|||.|:||||:||||||||||.:|||||||||:|: |||............|..|..|:
Human   254 SVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEGDPEAQRRVSKNSKYNA 317

  Fly   341 TTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQ 405
            .:|.|.:|:::|                    :.|||                        ||::
Human   318 ESTERESQDTVA--------------------ENDDG------------------------GFSE 338

  Fly   406 EWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVG 470
            ||.|.....:...    :||....|.......::.|.:.     .||||:|||||||||||||||
Human   339 EWEAQRDSHLGPH----RSTPESRAAVQELSSSILAGED-----PEERGVKLGLGDFIFYSVLVG 394

  Fly   471 KAS--SYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMED 533
            |||  :.|||.||||||||||||||||||||||::||||||||||||||:|.|||..:|:|||:.
Human   395 KASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQ 459

  Fly   534 LSAKQVFI 541
            |:..|.:|
Human   460 LAFHQFYI 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	231/434 (53%)
PSEN1	NP_000012.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..68		12/73 (16%)
		Presenilin	76..457	CDD:395857	231/434 (53%)
		Important for cleavage of target proteins. /evidence=ECO:0000269\|PubMed:30598546	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..333		7/47 (15%)
		Required for interaction with CTNNB1. /evidence=ECO:0000269\|PubMed:9738936	322..450		79/180 (44%)
		Required for interaction with CTNND2. /evidence=ECO:0000269\|PubMed:10037471	372..399		22/31 (71%)
		Important for cleavage of target proteins. /evidence=ECO:0000269\|PubMed:30598546	377..381		2/3 (67%)
		Important for cleavage of target proteins. /evidence=ECO:0000269\|PubMed:30598546	432..434		1/1 (100%)
		PAL. /evidence=ECO:0000305\|PubMed:16305624	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000269\|PubMed:10551805	464..467		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153136
Domainoid	1	1.000	433	1.000	Domainoid score	I584
eggNOG	1	0.900	-	-		E1_KOG2736
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1552
Isobase	1	0.950	-	0	Normalized mean entropy	S3257
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm41522
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	O	PTHR10202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720