DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psn and psen1

DIOPT Version :9

Sequence 1:	NP_001262111.1	Gene:	Psn / 40260	FlyBaseID:	FBgn0284421	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_571099.1	Gene:	psen1 / 30221	ZFINID:	ZDB-GENE-991119-4	Length:	456	Species:	Danio rerio

Alignment Length:	480	Identity:	244/480 - (50%)
Similarity:	307/480 - (63%)	Gaps:	82/480 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SGGPPT-----------NEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTD-VYL 135
            :|.|||           .:.:||..|||||:|||.||:||:|||:||||||.|:|||...| ..|
Zfish    38 NGQPPTAPPPQVVTDSEEDEDEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTQKDGQQL 102

  Fly   136 LYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFT 200
            :||||.|.:.....:...::.|::|::||:||||.:|:||||.|||::|..||..|:.:|||.|:
Zfish   103 IYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFS 167

  Fly   201 YLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPE 265
            .:||.|:.:.||:.|||.|..||:||||||||:.|||:|||||||.|||.::|||||||||||||
Zfish   168 LIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPE 232

  Fly   266 WTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQAT 330
            ||||.:|||||::||:|||.|:|||||||||||||||.||||||||||:|: |.|         .
Zfish   233 WTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVW-LFN---------M 287

  Fly   331 ASSSPSSSNSTTTTRATQNSLA--SPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSN 393
            |.|:.:.:||:......:|.:.  :|.|.|               .|||
Zfish   288 ADSAETRNNSSHPVPQQENQVVAMAPTAQA---------------EDDG---------------- 321

  Fly   394 LRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYR--TVTAPDQNHP---DGQEER 453
                    |||..|            ::.|..|.|..|.:.|.|  ....|....|   |..|||
Zfish   322 --------GFTPAW------------VDHQQHQLGPMQSTEESRRQIQEMPSARPPPPADDDEER 366

  Fly   454 GIKLGLGDFIFYSVLVGKAS--SYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFG 516
            |:|||||||||||:||||||  :.|||.||:|||||||||||||||||||::|||||||||||||
Zfish   367 GVKLGLGDFIFYSMLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFG 431

  Fly   517 LIFCFATSAVVKPFMEDLSAKQVFI 541
            |:|.|||..:|:|||:.|:..|.:|
Zfish   432 LVFYFATDNLVRPFMDQLAVHQFYI 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	232/442 (52%)
psen1	NP_571099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	9..56		4/17 (24%)
		Presenilin	64..446	CDD:279427	232/442 (52%)
		Important for cleavage of target proteins. /evidence=ECO:0000250\|UniProtKB:P49768	277..279		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..365		8/32 (25%)
		Important for cleavage of target proteins. /evidence=ECO:0000250\|UniProtKB:P49768	366..370		2/3 (67%)
		Important for cleavage of target proteins. /evidence=ECO:0000250\|UniProtKB:P49768	421..423		1/1 (100%)
		PAL. /evidence=ECO:0000305	422..424		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588189
Domainoid	1	1.000	419	1.000	Domainoid score	I624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1692
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm24389
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	O	PTHR10202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2736
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940