DRSC/TRiP Functional Genomics Resources

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Protein Alignment Psn and Psen1

DIOPT Version :9

Sequence 1:NP_001262111.1 Gene:Psn / 40260 FlyBaseID:FBgn0284421 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_062036.2 Gene:Psen1 / 29192 RGDID:3425 Length:468 Species:Rattus norvegicus


Alignment Length:546 Identity:252/546 - (46%)
Similarity:330/546 - (60%) Gaps:110/546 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRP 73
            |.||.:.|::|                  .|:::.::.....|.|::.                 
  Rat    20 SHSSSVRSQND------------------NQERQQHHDRQRLDNPESI----------------- 49

  Fly    74 SRLTGGGGGSGGPPTN----------EMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFY 128
                    .:|.|.:|          |.:||..|||||:|||.|||||:|||:||||||.|:|||
  Rat    50 --------SNGRPQSNFTRQVIEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFY 106

  Fly   129 NSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSF 193
            ...|..|:||||.|.:.....:...::.|:.|::||:||||.||:||||.|||::||.|||:||.
  Rat   107 TRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIVSSL 171

  Fly   194 MLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALV 258
            :|||.|:::||.|:.:.||:.:||.|..|::||||||||::|||:|||||||.|||.::||||||
  Rat   172 LLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALV 236

  Fly   259 FIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVT 323
            |||||||||||.:||.||::||:|||.|:||||:||||||||||.:|||||||||:|: |||...
  Rat   237 FIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAE 300

  Fly   324 -PQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPL 387
             ..::|.....:|..|...|....||::            .||:        |||          
  Rat   301 GDPEAQRRVPKNPKYSTQGTEREETQDT------------GTGS--------DDG---------- 335

  Fly   388 VTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEE 452
                          ||::||.|.....:...:   .:.:|..|.:......:|:.|      .||
  Rat   336 --------------GFSEEWEAQRDSHLGPHR---STPESRAAVQELSGSILTSED------PEE 377

  Fly   453 RGIKLGLGDFIFYSVLVGKAS--SYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITF 515
            ||:||||||||||||||||||  :.|||.||||||||||||||||||||||::||||||||||||
  Rat   378 RGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITF 442

  Fly   516 GLIFCFATSAVVKPFMEDLSAKQVFI 541
            ||||.|||..:|:|||:.|:..|.:|
  Rat   443 GLIFYFATDYLVQPFMDQLAFHQFYI 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsnNP_001262111.1 Presenilin 98..531 CDD:279427 232/435 (53%)
Psen1NP_062036.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 10/80 (13%)
Presenilin 76..458 CDD:395857 232/435 (53%)
Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768 288..290 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..338 12/77 (16%)
Required for interaction with CTNNB1. /evidence=ECO:0000250|UniProtKB:P49768 322..451 81/181 (45%)
Required for interaction with CTNND2. /evidence=ECO:0000250|UniProtKB:P49768 373..400 23/32 (72%)
Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768 378..382 2/3 (67%)
Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768 433..435 1/1 (100%)
PAL. /evidence=ECO:0000305 434..436 1/1 (100%)
Interaction with MTCH1. /evidence=ECO:0000250|UniProtKB:P49768 465..468 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346753
Domainoid 1 1.000 428 1.000 Domainoid score I577
eggNOG 1 0.900 - - E1_KOG2736
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 441 1.000 Inparanoid score I1606
OMA 1 1.010 - - QHG54370
OrthoDB 1 1.010 - - D357270at33208
OrthoFinder 1 1.000 - - FOG0002393
OrthoInspector 1 1.000 - - otm45642
orthoMCL 1 0.900 - - OOG6_101989
Panther 1 1.100 - - O PTHR10202
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1815
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.770

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