Protein Alignment Psn and Psen1

DIOPT Version :10

• Sequence 1: NP_524184.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_062036.2
• Gene: Psen1 / 29192
• RGDID: 3425
• Length: 468
• Species: Rattus norvegicus
• Alignment Length: 546
• Identity: 252/546 - (46%)
• Similarity: 330/546 - (60%)
• Gaps: 110/546 - (20%)

  Fly     9 SCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRP 73
            |.||.:.|::|                  .|:::.::.....|.|::.
  Rat    20 SHSSSVRSQND------------------NQERQQHHDRQRLDNPESI----------------- 49

  Fly    74 SRLTGGGGGSGGPPTN----------EMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFY 128
                    .:|.|.:|          |.:||..|||||:|||.|||||:|||:||||||.|:|||
  Rat    50 --------SNGRPQSNFTRQVIEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFY 106

  Fly   129 NSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSF 193
            ...|..|:||||.|.:.....:...::.|:.|::||:||||.||:||||.|||::||.|||:||.
  Rat   107 TRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIVSSL 171

  Fly   194 MLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALV 258
            :|||.|:::||.|:.:.||:.:||.|..|::||||||||::|||:|||||||.|||.::||||||
  Rat   172 LLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALV 236

  Fly   259 FIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVT 323
            |||||||||||.:||.||::||:|||.|:||||:||||||||||.:|||||||||:|: |||...
  Rat   237 FIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAE 300

  Fly   324 -PQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPL 387
             ..::|.....:|..|...|....||::            .||:        |||
  Rat   301 GDPEAQRRVPKNPKYSTQGTEREETQDT------------GTGS--------DDG---------- 335

  Fly   388 VTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEE 452
                          ||::||.|.....:...:   .:.:|..|.:......:|:.|      .||
  Rat   336 --------------GFSEEWEAQRDSHLGPHR---STPESRAAVQELSGSILTSED------PEE 377

  Fly   453 RGIKLGLGDFIFYSVLVGKAS--SYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITF 515
            ||:||||||||||||||||||  :.|||.||||||||||||||||||||||::||||||||||||
  Rat   378 RGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITF 442

  Fly   516 GLIFCFATSAVVKPFMEDLSAKQVFI 541
            ||||.|||..:|:|||:.|:..|.:|
  Rat   443 GLIFYFATDYLVQPFMDQLAFHQFYI 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_524184.1	Presenilin	98..531	CDD:460052	232/435 (53%)
Psen1	NP_062036.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		10/80 (13%)
		Presenilin	76..458	CDD:460052	232/435 (53%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..338		12/77 (16%)
		Required for interaction with CTNNB1. /evidence=ECO:0000250|UniProtKB:P49768	322..451		81/181 (45%)
		Required for interaction with CTNND2. /evidence=ECO:0000250|UniProtKB:P49768	373..400		23/32 (72%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	378..382		2/3 (67%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	433..435		1/1 (100%)
		PAL. /evidence=ECO:0000305	434..436		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000250|UniProtKB:P49768	465..468		1/2 (50%)