Protein Alignment Psn and Psen2

DIOPT Version :9

• Sequence 1: NP_001262111.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001122077.1
• Gene: Psen2 / 19165
• MGIID: 109284
• Length: 448
• Species: Mus musculus
• Alignment Length: 550
• Identity: 249/550 - (45%)
• Similarity: 319/550 - (57%)
• Gaps: 128/550 - (23%)

  Fly    14 LASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSN----------------QDQPDAAILAVPN 62
            :||:.:..|..:..:....|.|..|..|....|..:                ::.||
Mouse     5 MASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPD-------- 61

  Fly    63 VVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISF 127
               |..|...|.|.:|            :|||..|||||:|||.|||||:|||:||||||.|:.|
Mouse    62 ---RYACSGAPGRPSG------------LEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRF 111

  Fly   128 YNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSS 192
            |...:..|:||||.|.:|....:..:::.|:||::||:||||..|:||||.|||:.||||||:||
Mouse   112 YTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSS 176

  Fly   193 FMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMAL 257
            .||||:|||:||.|:|:.||:.|||||..|.:||||.|||:.|||:|||.|||.|||.::|||||
Mouse   177 LMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMAL 241

  Fly   258 VFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTV 322
            |||||||||:||.:|.|||::||:|||.|:||||:||||||||||.|||||||||.:|:.:
Mouse   242 VFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTV---- 302

  Fly   323 TPQQSQATASSSPSSSNSTTTTRATQNSLA---SPEAAAASGQRTGN-SHPRQNQRDDGSVLATE 383
                  ..|...|||          |.:|.   .||....|....|. |:|.
Mouse   303 ------GMAKLDPSS----------QGALQLPYDPEMEEDSYDSFGEPSYPE------------- 338

  Fly   384 GMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPD 448
                 .|::.|      .|:..|   .|.|
Mouse   339 -----AFEAPL------PGYPGE---ELEE----------------------------------- 354

  Fly   449 GQEERGIKLGLGDFIFYSVLVGKASS--YGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPI 511
             :||||:|||||||||||||||||::  .|||.||:|||:||||||||||||||:::||||||||
Mouse   355 -EEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPI 418

  Fly   512 SITFGLIFCFATSAVVKPFMEDLSAKQVFI 541
            ||||||||.|:|..:|:|||:.|::.|::|
Mouse   419 SITFGLIFYFSTDNLVRPFMDTLASHQLYI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	225/438 (51%)
Psen2	NP_001122077.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..74		14/79 (18%)
		Presenilin	82..438	CDD:366453	225/438 (51%)
		PAL	414..416		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H386
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1658
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54370
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm43573
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	LDO	PTHR10202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2736
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790