Protein Alignment Psn and Psen1

DIOPT Version :10

• Sequence 1: NP_524184.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001349200.1
• Gene: Psen1 / 19164
• MGIID: 1202717
• Length: 467
• Species: Mus musculus
• Alignment Length: 543
• Identity: 255/543 - (46%)
• Similarity: 335/543 - (61%)
• Gaps: 92/543 - (16%)

  Fly     2 AAVNLQASCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMR 66
            |.::..:..||.:.|::|:....|....:||:.|   :...|....||..|          ||.:
Mouse    14 AQMSEDSHSSSAIRSQNDSQERQQQHDRQRLDNP---EPISNGRPQSNSRQ----------VVEQ 65

  Fly    67 EPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNST 131
            :                     .|.:||..|||||:|||.|||||:|||:||||||.|:|||...
Mouse    66 D---------------------EEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRK 109

  Fly   132 DVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLL 196
            |..|:||||.|.:.....:...::.|:.|::||:|:||.||:||||.|||::||.|||:||.:||
Mouse   110 DGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVIMTILLVVLYKYRCYKVIHAWLIISSLLLL 174

  Fly   197 FIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIK 261
            |.|:::||.|:.:.||:.:||.|..|::||||||||::|||:|||||||.|||.::|||||||||
Mouse   175 FFFSFIYLGEVFKTYNVAVDYVTVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIK 239

  Fly   262 YLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVT-PQ 325
            ||||||||.:||.||::||:|||.|:||||:||||||||||.:|||||||||:|: |||... ..
Mouse   240 YLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEGDP 303

  Fly   326 QSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTF 390
            ::|.....:| ..|:....|.||:|            .:||        |||
Mouse   304 EAQRRVPKNP-KYNTQRAERETQDS------------GSGN--------DDG------------- 334

  Fly   391 KSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGI 455
                       ||::||.|.....:...:   .:.:|..|.:......:|:.|      .||||:
Mouse   335 -----------GFSEEWEAQRDSHLGPHR---STPESRAAVQELSGSILTSED------PEERGV 379

  Fly   456 KLGLGDFIFYSVLVGKAS--SYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLI 518
            ||||||||||||||||||  :.|||.||||||||||||||||||||||::||||||||||||||:
Mouse   380 KLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLV 444

  Fly   519 FCFATSAVVKPFMEDLSAKQVFI 541
            |.|||..:|:|||:.|:..|.:|
Mouse   445 FYFATDYLVQPFMDQLAFHQFYI 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_524184.1	Presenilin	98..531	CDD:460052	231/435 (53%)
Psen1	NP_001349200.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		15/87 (17%)
		Presenilin	76..457	CDD:460052	231/435 (53%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..357		17/100 (17%)
		Required for interaction with CTNNB1. /evidence=ECO:0000250|UniProtKB:P49768	322..450		82/180 (46%)
		Required for interaction with CTNND2. /evidence=ECO:0000250|UniProtKB:P49768	372..399		23/32 (72%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	377..381		2/3 (67%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	432..434		1/1 (100%)
		PAL	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000250|UniProtKB:P49768	464..467		1/2 (50%)