Protein Alignment Psn and spe-4

DIOPT Version :10

• Sequence 1: NP_524184.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_492095.1
• Gene: spe-4 / 172498
• WormBaseID: WBGene00004958
• Length: 465
• Species: Caenorhabditis elegans
• Alignment Length: 490
• Identity: 116/490 - (23%)
• Similarity: 209/490 - (42%)
• Gaps: 77/490 - (15%)

  Fly    88 TNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVK-F 151
            ::|:.....|::....||   ..:||.:.:.:...|.......:..|.|...|.:.:....:. |
 Worm     8 SSELVRSSQLRWTLFSVI---ANMSLTLSIWIGVYNMEVNSELSKTYFLDPSFEQTTGNLLLDGF 69

  Fly   152 WSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLF---------IFTYLYLEEL 207
            .:.:...|:|..|..:|  |..||:..|  ||:..||.||..::||         :|:.::.::.
 Worm    70 INGVGTILVLGCVSFIM--LAFVLFDFR--RIVKAWLTLSCLLILFGVSAQTLHDMFSQVFDQDD 130

  Fly   208 LRAYNIPMDYPTALLI-----MWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWT 267
            ...|     |.|.:||     ::.||  |:.:......|.|.|.:::...:|:::.:::..|..|
 Worm   131 NNQY-----YMTIVLIVVPTVVYGFG--GIYAFFSNSSLILHQIFVVTNCSLISVFYLRVFPSKT 188

  Fly   268 AWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATAS 332
            .|.||..:..|||.|||:|.|||:.:.|.|.:.::.:...:::|:            .:.:.||.
 Worm   189 TWFVLWIVLFWDLFAVLAPMGPLKKVQEKASDYSKCVLNLIMFSA------------NEKRLTAG 241

  Fly   333 SSPSSSN---STTTTRA--------TQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMP 386
            |:...:|   .:|..|.        |:......|......||....:|.....:...::..|..|
 Worm   242 SNQEETNEGEESTIRRTVKQTIEYYTKREAQDDEFYQKIRQRRAAINPDSVPTEHSPLVEAEPSP 306

  Fly   387 LVTFKSN----LRGNAEAAGFTQEWSANLSERVARRQIEVQSTQS-------------GNAQRSN 434
            :...:.|    |..:......|...|:|||...:...:......:             .|:..:|
 Worm   307 IELKEKNSTEELSDDESDTSETSSGSSNLSSSDSSTTVSTSDISTAEECDQKEWDDLVSNSLPNN 371

  Fly   435 EYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLL 499
            :.|..||.|..: ||:.   ::||.|||:|||:|:|:|::.|.....|:..:.||.||.:||.:.
 Worm   372 DKRPATAADALN-DGEV---LRLGFGDFVFYSLLIGQAAASGCPFAVISAALGILFGLVVTLTVF 432

  Fly   500 AIWRKALPALPISITFGLIFCFATSAVVKPFMEDL 534
            :......||||:.:..| .||:.:|..   |.|.|
 Worm   433 STEESTTPALPLPVICG-TFCYFSSMF---FWEQL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psn	NP_524184.1	Presenilin	98..531	CDD:460052	111/475 (23%)
spe-4	NP_492095.1	Presenilin	13..464	CDD:460052	115/485 (24%)