Protein Alignment LPP and Zyx

DIOPT Version :10

• Sequence 1: XP_047304053.1
• Gene: LPP / 4026
• HGNCID: 6679
• Length: 676
• Species: Homo sapiens
• Sequence 2: NP_652015.1
• Gene: Zyx / 317824
• FlyBaseID: FBgn0011642
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 210/657 - (31%)
• Similarity: 296/657 - (45%)
• Gaps: 118/657 - (17%)

Human    58 QLSEIPTMSHPSWLPPKSTGEPL-----GHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKP 117
            ||.|:.       ||...||.||     |.|...:....:..|.|:......|||       |..
  Fly     7 QLRELS-------LPKGDTGSPLVCIGHGKVAKLVAKISNNQNASVKRRLDIPPK-------PPI 57

Human   118 KYNPYKQPGGEGDFLPPPPP----PLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERR 178
            |||...|.......|....|    ||  .....::.|:.|....|..|..........||..:..
  Fly    58 KYNEMPQVPSSRQVLCSREPLYSQPL--IGVEKTMRGHMPFRKYLSSEFGVADTQINRKTTLDNP 120

Human   179 SSLDAEIDSLTSILADLE----CSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTAT 239
            :.|:.::::|......:|    .....||..|.:|.....|..:|      |.::..|   |.:.
  Fly   121 AILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLS------KSLIYSN---LGSV 176

Human   240 KKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS 304
            :|.                 |.||:........|.:|.|..:....:    |:..|...|.:..:
  Fly   177 RKE-----------------IETLELLTDETKISASTYSNVNETAMD----SSHSSTQKMLSVCT 220

Human   305 GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGM--DYAYIPPPGLQPEPGYGYAPNQG-----RYYE 362
            ..|..:     ....:|     ||||....:  .|:.:....|:......|..|..     :.|.
  Fly   221 NFISDN-----EKDELP-----PPPSPESAVSSSYSELRHATLEFNKPIDYLQNNQTTNPLQIYA 275

Human   363 GYYAAGPGYGGRNDS--DPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVS 425
            ..||......|::.|  |..|           ||....|...:..|...|.:   ..:|:.|.
  Fly   276 NQYAMQHDATGKSSSTYDSIY-----------EPINPRPCVADTLPRESYNL---HNSYVNDN-- 324

Human   426 APCAPPLQPKGGHSGQLGPS-----------SVAPSFRPEDELEHLTKKMLYDMENPPAD----- 474
                   .|...|...:..|           :...:|...:.:....|:.|.:..:.|.:
  Fly   325 -------NPNISHEYNISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEPVQEL 382

Human   475 EYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQ 539
            |.:|||.:|...|:||.:|||||||::|:.||||..|...|:|:||||::.|.|||..|:.|||:
  Fly   383 ENYGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEK 447

Human   540 CNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCK 604
            |:||.:||:|||||||||.|||.|||||:|.:||||:.|||||....:||.||||||||||.|||
  Fly   448 CSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCK 512

Human   605 EPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLL-SEGDNQGCYPLDGHILCKTCNSARIRVL 668
            :||||.||||||:|:|||||.||:.||:|||||.|| ||.:.:||||||.|:|||:||:.|::.|
  Fly   513 QPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQAL 577

Human   669 TAKASTD 675
            |.:.:::
  Fly   578 TNRMTSE 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LPP	XP_047304053.1	PHA03247	<83..452	CDD:223021	70/396 (18%)
		LIM1_TRIP6	480..533	CDD:188736	28/52 (54%)
		LIM2_TRIP6	540..592	CDD:188742	34/51 (67%)
		LIM3_TRIP6	600..665	CDD:188820	45/65 (69%)
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	28/52 (54%)
		LIM2_LPP	448..507	CDD:188740	41/58 (71%)
		LIM3_LPP	508..575	CDD:188821	46/66 (70%)