DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Las and Lias

DIOPT Version :9

Sequence 1:NP_524183.2 Gene:Las / 40259 FlyBaseID:FBgn0029158 Length:377 Species:Drosophila melanogaster
Sequence 2:NP_077791.1 Gene:Lias / 79464 MGIID:1934604 Length:373 Species:Mus musculus


Alignment Length:365 Identity:236/365 - (64%)
Similarity:282/365 - (77%) Gaps:5/365 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RALKTHAEAPIVVATRAASTNAEKLEEIRERLAKGPNFHDFVQNPDNTRNEWEQYDGKLRREKGE 67
            |:|.:..........||.|:..:|.:|.   |..||:..|||......::.|::|.|.|:|:|||
Mouse    10 RSLGSRIFGRYAFTVRALSSLPDKKKEF---LHNGPDLQDFVSGDLADKSTWDEYKGNLKRQKGE 71

  Fly    68 EQRLRLPPWLKTTIPVGKNYAKIKAQMRELKLSTVCEEARCPNIGECWGGGEHGTQTATIMLMGD 132
              ||||||||||.||:||||.|:|..:|.|.|.|||||||||||||||||||:.|.|||||||||
Mouse    72 --RLRLPPWLKTKIPMGKNYNKLKNTLRNLSLHTVCEEARCPNIGECWGGGEYATATATIMLMGD 134

  Fly   133 TCTRGCRFCSVKTARKPPPLDVNEPVNTATAIASWGLDYIVLTSVDRDDLPDGGSEHIAETVREI 197
            |||||||||||||||.|||||.|||.|||.|||.|||||:|||||||||:.|||:||||:||..:
Mouse   135 TCTRGCRFCSVKTARNPPPLDANEPDNTAKAIAEWGLDYVVLTSVDRDDVADGGAEHIAKTVSCL 199

  Fly   198 KARNSNIFVECLVPDFRGNLECVKTIANSGLDVYAHNIETVEKLTPYVRDRRAHYRQTLQVLTEA 262
            |.||..|.||||.|||||:|..|:.:|.|||||||||:|||.:|...|||.||::.|:|:||..|
Mouse   200 KERNPKILVECLTPDFRGDLRAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLRHA 264

  Fly   263 KRFNPNLITKSSIMLGLGETDEEIENTLKDLREAGVDCVTLGQYMQPTNKHLKVIEYVTPEKFKH 327
            |...|::::|:|||||||||||::..|||.||.|.|||:|||||||||.:||||.|||||||||:
Mouse   265 KEVQPDVVSKTSIMLGLGETDEQVYATLKALRAADVDCLTLGQYMQPTKRHLKVEEYVTPEKFKY 329

  Fly   328 WEERGNELGFLYTASGPLVRSSYKAGEFFITSILENRKKR 367
            ||:.|||||||||||||||||||||||||:.:::..||.:
Mouse   330 WEKVGNELGFLYTASGPLVRSSYKAGEFFLKNLVARRKTK 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LasNP_524183.2 LIAS_N 3..108 CDD:293486 48/104 (46%)
PLN02428 19..368 CDD:215236 233/349 (67%)
Radical_SAM 131..307 CDD:100105 120/175 (69%)
LiasNP_077791.1 LIAS_N 15..110 CDD:293486 46/99 (46%)
PLN02428 41..373 CDD:215236 228/331 (69%)
Radical_SAM 133..329 CDD:100105 137/195 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837924
Domainoid 1 1.000 227 1.000 Domainoid score I2499
eggNOG 1 0.900 - - E1_COG0320
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4997
Inparanoid 1 1.050 480 1.000 Inparanoid score I1445
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60997
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003202
OrthoInspector 1 1.000 - - oto93494
orthoMCL 1 0.900 - - OOG6_100980
Panther 1 1.100 - - LDO PTHR10949
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2153
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.760

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