DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5262 and tmem104

DIOPT Version :9

Sequence 1:	NP_001262109.1	Gene:	CG5262 / 40258	FlyBaseID:	FBgn0036988	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_693756.3	Gene:	tmem104 / 565387	ZFINID:	ZDB-GENE-070822-4	Length:	493	Species:	Danio rerio

Alignment Length:	506	Identity:	229/506 - (45%)
Similarity:	325/506 - (64%)	Gaps:	33/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EAAPTYSNLVGFIFIFNLIVGTGALTLPGVFARAGWMLSLIVIVLLAIISYMTVTFIIEAMACAN 73
            |....||..||.:::|||||||||||:|..||.|||::|:.:|..||.:|:||.||:|||||.||
Zfish     7 ETGEPYSPFVGLVYMFNLIVGTGALTMPKAFAAAGWVVSVSLITFLAFMSFMTTTFVIEAMAAAN 71

  Fly    74 AIRNWQTLQALRQSRSSAENSENDDNADDVSLASGAEQVGDFERVP-LTIQN-REFHYYQLSHKF 136
            |...|:..:   |...:..:|.:|.:.|:|.:...:|.|   |..| |::|. ....::.:..:.
Zfish    72 AQLRWKRRE---QEEVNDSDSSSDYSDDEVIIRGRSEPV---ETRPILSVQRAANIDHFDIVERV 130

  Fly   137 ELGEMATLFFNEFGRVMFYLCLIVYLYGDLSIYSAAVARSLRDVVCDQTNGTDTNNLMYWPGDFE 201
            |:|:||::|||:.|..|||:|:||||||||:||:|||..||.:|.|        .|.....|..:
Zfish   131 EMGQMASMFFNKVGVNMFYICIIVYLYGDLAIYAAAVPVSLMEVAC--------GNHSCSAGSVK 187

  Fly   202 NNTSLACWKEHTISRLNMYRVLLIGFTLIFGPFVYFNVQKTKYLQMLTAAFRWMAFTLMICISLK 266
            .|.:.:||  ..:.|.:.|||.|..|||:.|||.:||.|||||||:||:..||:|||:||.::|
Zfish   188 YNDTESCW--GPVRRKDAYRVFLAIFTLLLGPFTFFNAQKTKYLQILTSLMRWIAFTMMIILAL- 249

  Fly   267 LLISRG-AKGHPATFNVYGIPSLFGACVYSFMCHHSLPSLLAPIRHKSMVSKILSIDYIIICAFY 330
            :.|.:| .:|.|:...:.|:|:|||.|||||||.||||||:.||.:|..:|.::..|||:|..||
Zfish   250 IRIGKGHGEGKPSVAQISGVPNLFGVCVYSFMCQHSLPSLVTPISNKQRMSILVMADYILILCFY 314

  Fly   331 ILLAMTGIFAFER--IEDLYTLDFLP-YDVAYVDFWSGLLICIDYFLALFPIFTLSTSFPIVAIT 392
            .||::|.||.|:.  :.|:|||:|.. .||..|.       .:.|||.|||:||:||:|||:|:|
Zfish   315 ALLSLTAIFCFDSSLLRDMYTLNFTDNCDVLGVP-------VLRYFLGLFPVFTISTNFPIIAVT 372

  Fly   393 LKNNLQSLF-LDMSQYESYSVILRLCFPLLAIIPPFCITYFTESLSSLVAFTGTYAGTGIQYIIP 456
            |:||.::|| .|...|.  .|:.|:.|||:.::||..:.:.|..|.|||..||.|||||||||||
Zfish   373 LRNNWKTLFHRDGGTYP--WVVDRVVFPLITLVPPIIVAFCTHDLESLVGITGAYAGTGIQYIIP 435

  Fly   457 VFLVYFARRTCSELLGSGVVNRFKSPFKSSAWLVFVFIWSILCVCLVSINL 507
            .|||||:||....:||...||:.:|||:.:.|:.||.:|:..|:..|:.|:
Zfish   436 AFLVYFSRRHLEPVLGRDAVNKHRSPFRHTFWVCFVVLWATFCLMFVTANI 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5262	NP_001262109.1	SLC5-6-like_sbd	15..502	CDD:294310	225/493 (46%)
tmem104	XP_693756.3	SLC5-6-like_sbd	25..440	CDD:294310	202/440 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576232
Domainoid	1	1.000	293	1.000	Domainoid score	I1489
eggNOG	1	0.900	-	-		E1_KOG3832
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9802
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1757
OMA	1	1.010	-	-		QHG54287
OrthoDB	1	1.010	-	-		D387878at33208
OrthoFinder	1	1.000	-	-		FOG0007067
OrthoInspector	1	1.000	-	-		oto38617
orthoMCL	1	0.900	-	-		OOG6_104264
Panther	1	1.100	-	-	LDO	PTHR16189
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5150
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770