DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5262 and TMEM104

DIOPT Version :9

Sequence 1:	NP_001262109.1	Gene:	CG5262 / 40258	FlyBaseID:	FBgn0036988	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_060198.3	Gene:	TMEM104 / 54868	HGNCID:	25984	Length:	496	Species:	Homo sapiens

Alignment Length:	509	Identity:	221/509 - (43%)
Similarity:	330/509 - (64%)	Gaps:	36/509 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EAAPTYSNLVGFIFIFNLIVGTGALTLPGVFARAGWMLSLIVIVLLAIISYMTVTFIIEAMACAN 73
            |....||:.||.:::|||||||||||:|..||.|||::||:::|.|..:|::|.||:|||||.||
Human     7 ETGELYSSYVGLVYMFNLIVGTGALTMPKAFATAGWLVSLVLLVFLGFMSFVTTTFVIEAMAAAN 71

  Fly    74 AIRNWQTLQALRQSRSSAENSENDDNA----DDVSLASGAEQVGDFERVP-LTIQNR-EFHYYQL 132
            |..:|:.::.|::       .|:||::    .||.:....|:.   |:.| |::|.| ..:.:::
Human    72 AQLHWKRMENLKE-------EEDDDSSTASDSDVLIRDNYERA---EKRPILSVQRRGSPNPFEI 126

  Fly   133 SHKFELGEMATLFFNEFGRVMFYLCLIVYLYGDLSIYSAAVARSLRDVVCDQTNGTDTNNLMYWP 197
            :.:.|:|:||::|||:.|..:||.|:||||||||:||:|||..||..|.|..| |.|:..:   .
Human   127 TDRVEMGQMASMFFNKVGVNLFYFCIIVYLYGDLAIYAAAVPFSLMQVTCSAT-GNDSCGV---E 187

  Fly   198 GDFENNTSLACWKEHTISRLNMYRVLLIGFTLIFGPFVYFNVQKTKYLQMLTAAFRWMAFTLMIC 262
            .|.:.|.:..||  ..:.|::.||:.|..|||:.|||.:|:||||||||:||:..||:||.:||.
Human   188 ADTKYNDTDRCW--GPLRRVDAYRIYLAIFTLLLGPFTFFDVQKTKYLQILTSLMRWIAFAVMIV 250

  Fly   263 ISLKLLISRG-AKGHPATFNVYGIPSLFGACVYSFMCHHSLPSLLAPIRHKSMVSKILSIDYIII 326
            ::| :.|..| .:|||...:..|:.:|||.|||||||.||||||:.|:..|..:::::.:||::|
Human   251 LAL-IRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLI 314

  Fly   327 CAFYILLAMTGIFAF--ERIEDLYTLDFLPYDVAYVDFWSGLLICIDYFLALFPIFTLSTSFPIV 389
            .|||.||:.|.||.|  :.:.|:|||:|...||..       |..:.:||.|||:||:||:|||:
Human   315 LAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVG-------LAAVRFFLGLFPVFTISTNFPII 372

  Fly   390 AITLKNNLQSLFLDMSQYESYS-VILRLCFPLLAIIPPFCITYFTESLSSLVAFTGTYAGTGIQY 453
            |:||:||.::||  ..:..:|. |:.|:.||.:.::||..:.:.|..|.|||..||.||||||||
Human   373 AVTLRNNWKTLF--HREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQY 435

  Fly   454 IIPVFLVYFARRTCSELLGSGVVNRFKSPFKSSAWLVFVFIWSILCVCLVSINL 507
            :||.||||..||......|.||.|:.:|||:.:.|:.||.:|:..|...|:.|:
Human   436 VIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRHTFWVGFVLLWAFSCFIFVTANI 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5262	NP_001262109.1	SLC5-6-like_sbd	15..502	CDD:294310	217/496 (44%)
TMEM104	NP_060198.3	SLC5-6-like_sbd	<209..443	CDD:294310	115/243 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143366
Domainoid	1	1.000	291	1.000	Domainoid score	I1547
eggNOG	1	0.900	-	-		E1_KOG3832
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9802
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1833
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54287
OrthoDB	1	1.010	-	-		D387878at33208
OrthoFinder	1	1.000	-	-		FOG0007067
OrthoInspector	1	1.000	-	-		oto90055
orthoMCL	1	0.900	-	-		OOG6_104264
Panther	1	1.100	-	-	LDO	PTHR16189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2843
SonicParanoid	1	1.000	-	-		X5150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800