DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5274 and C7orf26

DIOPT Version :9

Sequence 1:	NP_649222.1	Gene:	CG5274 / 40257	FlyBaseID:	FBgn0036987	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	XP_005249902.1	Gene:	C7orf26 / 79034	HGNCID:	21702	Length:	589	Species:	Homo sapiens

Alignment Length:	421	Identity:	117/421 - (27%)
Similarity:	191/421 - (45%)	Gaps:	86/421 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DSNKLLLRKGDMKLDNYPTCAVEALTRLETLIASRNKQNMV-------MQIISEFIFLERTPKDG 63
            |....|||:..:      :.|.|.|..|:...:|:.:...:       ::::.||:|  :.||:
Human     3 DIRHSLLRRDAL------SAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVF--QVPKE- 58

  Fly    64 DVRKSQALPISQMNLFQEFQLIIALIEYFSRPGRDATRNAIFLSLF---GSHLTPQRSKLLSRLI 125
              |.:|.   .::|..||.||:..:..||....:|:.|..||.|||   |:.....|..||.:|:
Human    59 --RSAQP---KRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLV 118

  Fly   126 STAVSGSVAPLLSSAGTWMQQVGCKTPL--SLEVAQNIVSDFISYSRKTPEQLKQLPMVGPHFAA 188
            |.||:....|:|..|.:|:|    :||:  .:.:|:.:|.|:......:.:.|||:....|.|..
Human   119 SMAVAVCRIPVLECAASWLQ----RTPVVYCVRLAKALVDDYCCLVPGSIQTLKQIFSASPRFCC 179

  Fly   189 NFMVAVADLYLNEQRSPTLNPPPDALLDTITEWMMENPTLCQAS--QQPLV--LPAGAIAMPFTT 249
            .|:.:|..||  :..|..|.||.| ||:.|..|:.|:|.|...:  ..|:.  ||.|.:.:   |
Human   180 QFITSVTALY--DLSSDDLIPPMD-LLEMIVTWIFEDPRLILITFLNTPIAANLPIGFLEL---T 238

  Fly   250 PLAGLLRWVVLAPL--------------VSNRSA--------------YSNLHLSLLRALQQLVS 286
            ||.||:||.|.|||              |||:..              ||.||||:|:.|..|..
Human   239 PLVGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPGVGMDRDSHLLYSKLHLSVLQVLMTLQL 303

  Fly   287 S-------GESTALPSQDLMQIVKSLQSYCARLAESKTDPQADAAYQKCMERFAQAVQIALSSN- 343
            .       |....:....::.:|:.:.    |||:......|....:..::|.|||:|:|::|.
Human   304 HLTEKNLYGRLGLILFDHMVPLVEEIN----RLADELNPLNASQEIELSLDRLAQALQVAMASGA 364

  Fly   344 --CITNQIQLLCLLESLPPHKLMK--IVIEA 370
              |..:.::.||  ..||.:|.:.  :|.:|
Human   365 LLCTRDDLRTLC--SRLPHNKTLNFGVVCKA 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5274	NP_649222.1	DUF4507	14..360	CDD:291625	109/399 (27%)
C7orf26	XP_005249902.1	DUF4507	2..381	CDD:291625	113/407 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160027
Domainoid	1	1.000	115	1.000	Domainoid score	I6055
eggNOG	1	0.900	-	-		E1_28PM8
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11445
Inparanoid	1	1.050	120	1.000	Inparanoid score	I4777
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49810
OrthoDB	1	1.010	-	-		D1387798at2759
OrthoFinder	1	1.000	-	-		FOG0007054
OrthoInspector	1	1.000	-	-		oto91618
orthoMCL	1	0.900	-	-		OOG6_109156
Panther	1	1.100	-	-	LDO	PTHR14540
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5565
SonicParanoid	1	1.000	-	-		X5922
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800