DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zye and ram-5

DIOPT Version :9

Sequence 1:	NP_649220.1	Gene:	zye / 40255	FlyBaseID:	FBgn0036985	Length:	2284	Species:	Drosophila melanogaster
Sequence 2:	NP_510422.2	Gene:	ram-5 / 181550	WormBaseID:	WBGene00004301	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	751	Identity:	129/751 - (17%)
Similarity:	215/751 - (28%)	Gaps:	296/751 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGHIFVWALLLVTTRGTDLSDDEALNDVLGELEFDDSSPRLTRDTSLSAKHIEKI-DVKCDQGSG 67
            :|:||.:.:|..:|                  :||::             |:..: .|.|   |.
Worm     9 IGYIFSFVVLATST------------------DFDNA-------------HVMGVPQVTC---SA 39

  Fly    68 MMVEVEFSED--FEGVIYSQGYFSDPKCNYVKGDRSGRSFTFTVPYDGCGSKPSCSVCASIENIL 130
            .::.|.|:.:  |:|.|........|.||:.......::.||.:....|.            |.:
Worm    40 KLITVSFNTNIPFQGRISVFDKLFIPACNHDYSTNIQKNATFQMDILKCA------------NPM 92

  Fly   131 IIQDDRDIQNSF-DIA-RKISCSRGDEREKTVYFKPFVVDMLE---VISVDTPSGPVEC------ 184
            .:::...:..:: :|. ..:..:..|        :.|:|:.|:   :..|:......:|
Worm    93 FLKNGSRLLRAYVEIGFHPLVMTNSD--------RTFLVECLDNTIMPIVNRAQSFADCTHLVRM 149

  Fly   185 ---W-----MEIGTGTP-------PNVKPIQGTLTLGTDITFTINVKHSEQAWDINILQCYASDD 234
               |     .::|....       ||....|         ||..|.....|...|
Worm   150 ASEWSSMSEFQVGDAIVHEWSCKLPNPAKTQ---------TFLTNCNALSQNGQI---------- 195

  Fly   235 MDFEARTTKRLQLSDKRGCSIKEKIFGEWRKFEAGSSLTSTYYNTLKAFRFPDRSQVYLKCDIEL 299
                      :.|.|:.||.|..::.|:    ...|......|...:.|:|....:..::|.:|.
Worm   196 ----------IHLIDENGCVIDSELMGD----IVYSDHVPKLYARARIFKFLTDDKYRIECTLEF 246

  Fly   300 CNGACKRDYTCGSLRSLTCPEGSTDPQCLQDHLISP-KPRCYPGSNEPGCPRPTSPPPTTIRIPI 363
            ||..                              || |.|.:|    |.|        ...:..|
Worm   247 CNNG------------------------------SPCKDRVFP----PKC--------AFTKEEI 269

  Fly   364 ASTFTPRPRCYPGSNDPSCNETPQT--TSLPSCPLGSTDPRCRVAPP-ATKKPRCFSGSR--DPE 423
            .|..|.             |:..|:  |::|..|..:.|.|.:::.. .|.|...::.::  .|.
Worm   270 TSRSTK-------------NQLEQSGMTTMPGIPSSAYDSRLKISSAWLTIKLNQYTETKGLHPR 321

  Fly   424 CQPATYLPPTTRRSSTKPRCYPGSTD-----------------------PDCQPATRAPI---TT 462
            ....|:|.||...:.:     |...|                       ||......|.|   :.
Worm   322 YHLKTFLDPTLHETIS-----PNDADHFLMGISYREPIPKLSSQSELSHPDNNRVEGARILHSSA 381

  Fly   463 VKPGCYPGSDDPE-------------CQPATYVPQT------------TRRPSITTKRPRCYPGS 502
            .:|...|..|..|             .:|...|.:.            |.:..:.|::...:...
Worm   382 FQPIISPPIDSHEEFIETITFGSNLNSEPIVNVQKEMHLQKEPVHKVFTHKDPLKTEKTEKFMKL 446

  Fly   503 TDPECQPRTRPTI--TTSQPRCSQGSTDPECQPATYLPPTTRRTPIPTTRVPLTTS--------- 556
            ...|.:.|.....  ||.|.|..          .|.:|.|.    |.||..|:|:|
Worm   447 VQIENEDRNHGAALETTQQSRMF----------TTTMPSTM----ISTTTTPMTSSSRTDKLPSE 497

  Fly   557 ------------------KPNCYPGSTDTRCPQAPGPRCYPGSPDPSCQPPTRITQK-PPTSPQP 602
                              |.:.....|:|....|...:.|         ..|..|:| .||:|.
Worm   498 HFNHPELDTFEKPKKSFEKSHSLVQMTETTTAPAANLKFY---------STTASTKKLTPTTPY- 552

  Fly   603 KCYPGSSDPECLNCYPGSPDPRCPK-----VPTTKK 633
                .|:.||.....|.|..|...:     |||.||
Worm   553 ----ASAPPESSTQTPNSTKPTSIRNVTHSVPTVKK 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zye	NP_649220.1	ZP	61..313	CDD:214579	45/279 (16%)
ram-5	NP_510422.2	Zona_pellucida	36..264	CDD:391783	52/325 (16%)
ram-5	NP_510422.2	PRK13042	522..>590	CDD:183854	21/77 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930