DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zye and M02G9.1

DIOPT Version :9

Sequence 1:	NP_649220.1	Gene:	zye / 40255	FlyBaseID:	FBgn0036985	Length:	2284	Species:	Drosophila melanogaster
Sequence 2:	NP_001254244.1	Gene:	M02G9.1 / 174597	WormBaseID:	WBGene00010830	Length:	1499	Species:	Caenorhabditis elegans

Alignment Length:	1858	Identity:	398/1858 - (21%)
Similarity:	583/1858 - (31%)	Gaps:	623/1858 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 RSQVYLKCD---IELCNGACKRD----YTCGSLRSLTCPEGSTDPQC------LQDHLISPKPRC 339
            |:::...|.   :..|..:|.:.    :.|    |.|| |.:.|..|      ...|:
Worm    68 RAEINSDCSATCVRACIPSCSKSTGNTFAC----STTC-ESTCDKTCASAAQQAMSHI------- 120

  Fly   340 YPGSNEPGCPRPTSPPPTTIRIPIASTFTPRPRCYPGSNDPSCNETPQTTSLPSCPLGSTDPRCR 404
                       ..|||.....:|||:..|.         |.||....|.....:|.       .:
Worm   121 -----------QVSPPNPQPLVPIAAAPTV---------DDSCQNVCQNVCQGACV-------SQ 158

  Fly   405 VAPPA----TKKPRCFSGSRDPECQPATYLPPTTRRSSTKPRC----------YPGSTDPDCQPA 455
            .:|||    |.:..|..|     |.....||.|:..|:..|..          :..:..|.|..:
Worm   159 NSPPAVCQQTCRQSCQFG-----CATNEQLPTTSSTSTNAPTIKITLNINDAYFDSNCAPKCTQS 218

  Fly   456 TRA-------PITTVKPGCYPGSDDPECQPATYVPQTTRRP---SITTKRPR----CYPGSTDPE 506
            ..:       |..:....|     :.||.     .:.:.||   .:...:|:    ..|.:....
Worm   219 CHSQCISQGNPAASCSNSC-----NTECS-----DKCSTRPVQAQVQQIQPQQVQITIPQTCQSR 273

  Fly   507 CQPRTRPTITTSQPRCSQGSTDPECQ------PATYLPPTTRRTPIPTTRVPLTTSKPNCYPG-- 563
            |:.|...|.|.|||.....|....||      .|...|.:|..||:....:...|..|.|.|.
Worm   274 CENRCLSTCTASQPSVCAPSCSTACQLSCDSIGAATAPQSTNPTPVEVRALCTPTCMPQCLPSCT 338

  Fly   564 ----STDTRCP--------QAPGP--------RCYPGSPDPSCQP----PTRITQKPPTSPQPKC 604
                :|.|:.|        .||.|        :|.| |..|:|||    |..:|.:.|.....:|
Worm   339 ATTTTTTTQTPYIQTLAPAPAPAPVQIQIIQKQCVP-SCMPACQPSCTNPVPLTTQAPVPVVNQC 402

  Fly   605 YPGSSDPECL-NCYPGSPDPRCPKVPTTKKAGCYEGSDDPRCQPATYLPPSTRRPPTIAPRPRCY 668
            .| ...|:|| :|......|:.    .|:...|.     |:||||                  |
Worm   403 IP-PCQPQCLQSCLEQHIQPQV----VTQLPQCI-----PQCQPA------------------C- 438

  Fly   669 LGSTDPSCPQQTQPTTRTPITTIKPRCFPGSNDPECQPATTRRPLTTSKPNCYPGSTDRRCPQEP 733
                :|.|.|:|..||.|                          .||..|..   |||...|..|
Worm   439 ----EPQCIQETTTTTTT--------------------------TTTQSPQV---STDEPVPDYP 470

  Fly   734 VTTSRPRCYPGSSDPECQPATLVPPTTVRTTITTSRQRCYPGSSDPSCQP-PTTRKPITTPKPNC 797
            :.|:....:|.:::||.:...|   ||:...:.|:.: .....::|..:| |......|||:|..
Worm   471 LDTTSTAPFPSTTEPEYEDEEL---TTIEPEVETTTE-SVELETEPEPEPEPEPEPDYTTPEPID 531

  Fly   798 YPGSTDSRCPQTPRTTQQPRCYPGSTDPD--CQPATYLPPTTARTTITTAKPRCYPGSSDPYCQP 860
            |             ||.:|..||....|.  ..|:|..||:|:..|..|..|      |.|...|
Worm   532 Y-------------TTVEPYDYPQYDQPSTPSTPSTPSPPSTSTITYPTLPP------SQPTLPP 577

  Fly   861 PTTKKPNCYPGSTDSRCPQKPPITPKPKCYPGSTDLECLNCYPGSPDPRCPKVPTTKKAGCFDGS 925
            ...::..|.| :....|.|        .|......|..|:| |.:..|.|
Worm   578 TQPQRDQCLP-ACQPTCNQ--------NCIVAMQVLLYLSC-PEACRPAC--------------- 617

  Fly   926 DDPKCQPATYL--PPSTKR--TPT-IAPKPRCYPGSKDPGCPQITTRAPTSTSRPRC-------- 977
             |||| ...||  .|||.:  .|| :|.:.||                 .|...|.|
Worm   618 -DPKC-AYQYLRSNPSTPQHYNPTALASQSRC-----------------VSACMPACLLDCVLPY 663

  Fly   978 YPGSTDPECHPTTSSPAITRIPVTTRIPLTTAKPRCYPGSQEPGCQPATRPP--ITTSKPRCY-- 1038
            :...|.|     |.||.:....:...:|:...:.|....:|....|.:|:.|  ...::|:.|
Worm   664 FGDKTLP-----TLSPRVVVEQIPEEMPVDWGRLRDQATNQPLYLQASTQNPQGYLQTRPQAYVQ 723

  Fly  1039 PGSLDPECQPS--TYLPPTPVRTTV--PTIPTTRIPVTTSKPNCYPGSTDRRCPKEPVTTPKPRC 1099
            |.|.....:||  ||:.|:..:.:.  ||.|:.:...|......:|         :..|......
Worm   724 PASQSQPAKPSATTYVQPSSAQQSYVQPTQPSQQAHQTYQNAQPHP---------QAQTIHLQYK 779

  Fly  1100 YPGSPN-PECQKATYSPPTTRTPVTTSKPN-----CYPGSTDSRCPQKPPTTLKPKCSPGSSDPE 1158
            ..|:|: |..|.|..|.||....:...:..     .:........|.:|.:        |:..|.
Worm   780 VTGAPSTPTLQFAQASQPTQSFTLAQHQAQNQAKALHASHAAYNSPSQPVS--------GAYQPW 836

  Fly  1159 CLNCYPGSPDPRCPKVPTTKKSGCFD--------GSQDPRCQ-----------------PATYLP 1198
            .:           ||.|.|.....::        ||| |:.|                 |..||.
Worm   837 SV-----------PKTPLTMPGSLYNTASPVPGLGSQ-PKFQMQMVQVGGVPKNLNPSTPVNYLT 889

  Fly  1199 PSSRRPP----TTAP--KPRCHPGSTDPSCPQPTQPITTRLPITTQKARCY------PGSTAPEC 1251
            .:.:..|    :.||  |.:..|....|: |.|.:..:..:|:|    |.:      |.|.:...
Worm   890 VNLKSAPGVQGSQAPIVKFKSPPTQISPA-PPPAKQASRTIPLT----RLFSTYGSVPKSLSNHI 949

  Fly  1252 QPAT--TPTPTSTRPITTITTSKPNCYPGS--TDRRCPQIPVTTTKPRCYPGSTDPQCQPATYLP 1312
            |.::  ||.|:.|..:....|...:..|.:  .:..|        .|:|.| ..||.|     :.
Worm   950 QSSSLATPQPSETNDVIDDNTPFVDVLPKNDPIEEEC--------VPQCMP-QCDPYC-----IS 1000

  Fly  1313 PTTVTTVRPRCYPGSNDP-GCQPPQTTKTPITTSKPVCYLGSTDSRCRQNPSTTQKPKCSVGSTD 1376
            ....:...|...||::.| .|.|..:.:...|...|:                         |..
Worm  1001 QHRYSLRSPTASPGASCPKACMPECSNQCVATLQCPL-------------------------SCQ 1040

  Fly  1377 PECQPATYLPPTTVSPTIPTTKPRCYPGSTDTSCQPKTYSPPTSRPLITTSKPRCYPGSPDPECQ 1441
            |.|||:....|..:..|:...:..|.     ..||                 |.|     ||:|.
Worm  1041 PACQPSCLQKPPIIKITVTGQQVGCV-----EQCQ-----------------PAC-----DPKCI 1078

  Fly  1442 PATYLPPTTRRTTIPVTKPRCYPGSSDPECQPETYSPPTTRP----PVTTSKPNCYPGSTDSRCP 1502
            .||...|:.:...:..|                |.:||...|    .:.:....|.|..| |:|.
Worm  1079 IATIKTPSQQPQFVVTT----------------TQAPPAPAPQQQQQLASCPQLCQPQCT-SQCV 1126

  Fly  1503 QKPPTTLQPKCYPGSSDPECLNCYPGSPDPR-CPKIPTTKKAGCFE--GSDDPRCQPATYLPPSS 1564
            |:.....|..|..|        |...:||.| |..:       |.|  .|:.||.||....|
Worm  1127 QQQQCPCQQTCQTG--------CQQHNPDARVCQNV-------CVEVCASECPRTQPTVQQP--- 1173

  Fly  1565 RRPPTIAPKPRCYPGSTDPSCPQPTQPTTTRTPLTTSRPRCYPGSTDRECQPATYSPPTSRSQIT 1629
              .|.:..:| .|.....|....|..|..|..|...|.|:........||.|.  ...:..:|..
Worm  1174 --APQLVQQP-IYQTVQAPLSYVPVVPVATSAPSQASGPQITINFAVPECIPV--CEQSCNTQCV 1233

  Fly  1630 TLKPRCYPGSK-DPECQPATYAPPTTRTPVTTSKPNCYPGSTDKRCPQEIVTTQKPRCYPGSPDP 1693
            ...|:.:.||. :.:||.|.    .|:||...:.|                   .|.|     .|
Worm  1234 EKFPQEHCGSVCNSQCQTAC----ATQTPAVQAAP-------------------APSC-----QP 1270

  Fly  1694 ECQPATYLPPTTSRTTIPPTRPRCYPGSSDPSCQPT---TNLPPTTRTPVTTRKPNCYPGSTDSR 1755
            :||||                  |.|.......||.   .||  .|.:.|......|.|     .
Worm  1271 QCQPA------------------CEPVCIAQQAQPVRIQINL--ATASSVLQASDACQP-----M 1310

  Fly  1756 CPQTPQTTIRPKCYPGSTDPDCQPTT-NLPPSTPRPTVPT-TQPRCYP-GSSDPYCQS----PTT 1813
            |.|             |...:||.|| |:..:|.:|...: .|..|.| |:|.|..|:    |..
Worm  1311 CEQ-------------SCVQECQSTTLNVQAATCQPACQSICQQSCAPLGTSAPVMQTIPVVPVA 1362

  Fly  1814 RAPLTTPKPNCYPGSTDSRCPQKPPTTLAPKCFPG------SSDPECLNCYPGSPDPRC-----P 1867
            .||:.:.:                  ..||||...      |:.|:|:.....|....|     |
Worm  1363 TAPVASTQ------------------LCAPKCISDCQGLCKSNSPQCIQGCDASCQQLCGTAPTP 1409

  Fly  1868 KVPTTRKAGCSDGSDDPRCQPATYLPPSTTRAPKPNCYTGSTDPRCPQPT--QATTLRTPVTTTR 1930
            .||.|....|:             ||          |     |.:|.|..  ||.|. .|...:.
Worm  1410 AVPLTVNYNCN-------------LP----------C-----DQQCTQQCYHQAPTC-APACASA 1445

  Fly  1931 CYPGSPDPDCQPATRAPVTTLRPKC-YSGSNDPECLPS 1967
            |....|...|:.|.:   |..:.:| :||.|..:|.|:
Worm  1446 CEAQCPVVSCEDACQ---TVCKGQCVFSGQNSRQCGPA 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zye	NP_649220.1	ZP	61..313	CDD:214579	5/31 (16%)
M02G9.1	NP_001254244.1	PRK10263	<670..>805	CDD:236669	33/148 (22%)
M02G9.1	NP_001254244.1	PRK10263	<1158..>1368	CDD:236669	67/283 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000