DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and LYP1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_014131.1	Gene:	LYP1 / 855453	SGDID:	S000005212	Length:	611	Species:	Saccharomyces cerevisiae

Alignment Length:	480	Identity:	99/480 - (20%)
Similarity:	178/480 - (37%)	Gaps:	116/480 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSGICTKMNRTKSV--PTDVMETP---------LNRCLNTFDIALLGIGHMVGAGIYVLTGTVAK 66
            ::.|...:.|.:.|  .||:.|..         :.|.|....|.::.:|..:|.|::|...|...
Yeast    73 VNSITNSLTRLQVVSHETDINEDEEEAHYEDKHVKRALKQRHIGMIALGGTIGTGLFVGISTPLS 137

  Fly    67 EMAGP-GIILSFILAGFISMLAALCYAEFGTRVPKAGSAYVYTY--------ISMGEFWAFVIGW 122
            . ||| |.::::|..|.|.........|..|.:|...|..|::.        :|.|..:.|  .|
Yeast   138 N-AGPVGSLIAYIFMGTIVYFVTQSLGEMATFIPVTSSITVFSKRFLSPAFGVSNGYMYWF--NW 199

  Fly   123 NILLE---HMLGAASVARAWSGYVDSMLGGWIGNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAA 184
            .|...   .::|  .|...|:..|.  |..||....:.:|             ::.|....||
Yeast   200 AITYAVEVSVIG--QVIEYWTDKVP--LAAWIAIFWVIIT-------------LMNFFPVKVY-- 245

  Fly   185 ALAGGVKATAVFNSLLTLVNIAVMVLVISVG----------FWYADGKNW-------SEAEGGFL 232
               |..:.......:|.::...:..|:|..|          :|...|. |       .::||.||
Yeast   246 ---GEFEFWVASVKVLAIMGYLIYALIIVCGGSHQGPIGFRYWRNPGA-WGPGIISSDKSEGRFL 306

  Fly   233 PYGVGGVIAGAATCFYAFVGFDSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIP 297
                 |.::......:.:.|.:.:..:..||.||..::|.|....:|.:.:.||:....:.|::|
Yeast   307 -----GWVSSLINAAFTYQGTELVGITAGEAANPRKTVPRAINKVVFRIVLFYIMSLFFIGLLVP 366

  Fly   298 ISEINPAAS--------------------LPEAFGQLNLSWAKYLISIGALCGMTTTLLGSLFAL 342
            .::...:||                    ||:.|.      |..||::.:... :...:||
Yeast   367 YNDSRLSASSAVIASSPFVISIQNAGTYALPDIFN------AVVLITVVSAAN-SNVYVGS---- 420

  Fly   343 PRCMYAMASDGLLFSCFGKINPTTQ-VPLLNLVVSGVMSACLALVFD------LAKLVEFMSIGT 400
             |.:|::|..|.....||.:  |.| ||.|.:|.:..:.....||.:      ...|:...::..
Yeast   421 -RVLYSLARTGNAPKQFGYV--TRQGVPYLGVVCTAALGLLAFLVVNNNANTAFNWLINISTLAG 482

  Fly   401 LLAYTIVSASVI----ILRYRPMER 421
            |.|:..:|.:.|    .|::|.:.|
Yeast   483 LCAWLFISLAHIRFMQALKHRGISR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	94/459 (20%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
LYP1	NP_014131.1	2A0310	107..583	CDD:273334	93/446 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870