DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and ALP1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_014129.1	Gene:	ALP1 / 855451	SGDID:	S000005214	Length:	573	Species:	Saccharomyces cerevisiae

Alignment Length:	560	Identity:	115/560 - (20%)
Similarity:	200/560 - (35%)	Gaps:	149/560 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGP-GIILSFILAGFISML 86
            |:|.|.:..|  :.|.|....|.::.:|..:|.|:.:..|..... ||| |.::|::..|.:...
Yeast    56 TESSPQERRE--VKRKLKQRHIGMIALGGTIGTGLIIGIGPPLAH-AGPVGALISYLFMGTVIYS 117

  Fly    87 AALCYAEFGTRVPKAGSAYVYT--YIS--MGE-----FWAFVIGW--NILLE-HMLGAASVARAW 139
            ......|..|.:|...|..|:.  ::|  :|.     :|   :.|  ...|| .:||  .|.:.|
Yeast   118 VTQSLGEMVTFIPVTSSFSVFAQRFLSPALGATNGYMYW---LSWCFTFALELSVLG--KVIQYW 177

  Fly   140 SGYVDSMLGGWIGNTTLELTG---------GIHEPGLAQYPDV--LAFLV---CIVYAAALAGGV 190
            :..|.  |..||......||.         |..|..:|....:  |.|::   |:|..|..:.|
Yeast   178 TEAVP--LAAWIVIFWCLLTSMNMFPVKYYGEFEFCIASIKVIALLGFIIFSFCVVCGAGQSDG- 239

  Fly   191 KATAVFNSLLTLVNIAVMVLVISVGFWY------------ADGKNWSEAEGGFLPYGVGGVIAGA 243
                                  .:||.|            :..||    ||.||     |.::..
Yeast   240 ----------------------PIGFRYWRNPGAWGPGIISSDKN----EGRFL-----GWVSSL 273

  Fly   244 ATCFYAFVGFDSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIPIS--------- 299
            ....:.:.|.:.:..:..||.||..::|.|....:..:.|.|||....:.|::|.:
Yeast   274 INAAFTYQGTELVGITAGEAANPRKALPRAIKKVVVRILVFYILSLFFIGLLVPYNDPKLDSDGI 338

  Fly   300 -----------EINPAASLPEAFGQLNLSWAKYLISIGALCGMTTTLLGSLFALPRCMYAMASDG 353
                       |.:....||:.|.      |..||:| ...|.:...:||     |.:|:::.:.
Yeast   339 FVSSSPFMISIENSGTKVLPDIFN------AVVLITI-LSAGNSNVYIGS-----RVLYSLSKNS 391

  Fly   354 LLFSCFGKINPTTQVPLLNLVVSGV--------MSACLALVFDLAKLVEFMSIGTLLAYTIVSAS 410
            |.......:. ...||..:::.:.|        :||.....|:.  |:....:....|:.::|.|
Yeast   392 LAPRFLSNVT-RGGVPYFSVLSTSVFGFLAFLEVSAGSGKAFNW--LLNITGVAGFFAWLLISFS 453

  Fly   411 VIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQSSMDTSSPTSEMIEEVLAGRLKAQFRC 475
            .|        |....||...::       .||....:|.....:...|..|..::   |...|..
Yeast   454 HI--------RFMQAIRKRGIS-------RDDLPYKAQMMPFLAYYASFFIALIV---LIQGFTA 500

  Fly   476 LEPLLGRFEP----GSVVSVAVMLFIFLSFAICVELKVSW 511
            ..|   .|:|    .:.:|:.:.|.|:|||.:..:.::.|
Yeast   501 FAP---TFQPIDFVAAYISIFLFLAIWLSFQVWFKCRLLW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	112/551 (20%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
ALP1	NP_014129.1	2A0310	67..545	CDD:273334	111/547 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345703
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.890