DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and PUT4

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_014993.1	Gene:	PUT4 / 854530	SGDID:	S000005875	Length:	627	Species:	Saccharomyces cerevisiae

Alignment Length:	588	Identity:	126/588 - (21%)
Similarity:	214/588 - (36%)	Gaps:	166/588 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSRRAILRHILSGICTKMNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKE 67
            ||...|...::..:  .:.::.||..|.....|.:.|.:..:.|:.:|..:|.|:.|.|.:....
Yeast    76 SSNGTIREDLIMDV--DLEKSPSVDGDSEPHKLKQGLQSRHVQLIALGGAIGTGLLVGTSSTLHT 138

  Fly    68 MAGPGIILSFIL--AGFISMLAAL----CYAEFGTRVPKAGSA--YVYTYI--SMGEFWAFVIGW 122
            ....|:.:|:|:  |....::.||    |:.. |.....|||.  .|..|:  |:|    |..||
Yeast   139 CGPAGLFISYIIISAVIYPIMCALGEMVCFLP-GDGSDSAGSTANLVTRYVDPSLG----FATGW 198

  Fly   123 NILLEHMLGAASVARAWSGYVDSMLGGWIGNTTLELTGGIHEPGLAQYPDVLAFLVCIVY----- 182
            |....:::..|:...|.||.|:.    |    |..:..|:.          :...:|:|.
Yeast   199 NYFYCYVILVAAECTAASGVVEY----W----TTAVPKGVW----------ITIFLCVVVILNFS 245

  Fly   183 AAALAGGVKATAVFNSLLTLVNIAVMVLVISVGFWYADGKN--------WSEAEGGFLPYGVG-- 237
            |..:.|..:.......:|.:|.:.::..::   || ..|.|        | :..|.|..:..|
Yeast   246 AVKVYGESEFWFASIKILCIVGLIILSFIL---FW-GGGPNHDRLGFRYW-QHPGAFAHHLTGGS 305

  Fly   238 ---------GVIAGAATCFYAFV-GFDSIATSGEEAKNPSVSIPVATVISLFVVTVGYILVSAAL 292
                     |:|.||    :||: |.:.:..:..|..:...:|..|:...::.:...|:|.:.|:
Yeast   306 LGNFTDIYTGIIKGA----FAFILGPELVCMTSAECADQRRNIAKASRRFVWRLIFFYVLGTLAI 366

  Fly   293 TLMIPISE---INP-------AASLPEAFGQLNLSWAKYLISIGALCGMTTTLLGS---LFALPR 344
            ::::|.::   :|.       |.|.|...|..| :..|.|..|...|.:|:....:   :||..|
Yeast   367 SVIVPYNDPTLVNALAQGKPGAGSSPFVIGIQN-AGIKVLPHIINGCILTSAWSAANAFMFASTR 430

  Fly   345 CMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMSACLALVFDLAKLVEFMSIGTLLAYTIVSA 409
            .:..||..|....|.|:|| ...||   .|..||...|                 :.|||..||:
Yeast   431 SLLTMAQTGQAPKCLGRIN-KWGVP---YVAVGVSFLC-----------------SCLAYLNVSS 474

  Fly   410 SVIILRYRPMERIHTTIRVPAVAGSPDDDDDDDEDVASQ-SSMDTSSPTSEMIEEVLAGRLKAQF 473
            |.                               .||.:. |::.|           ::|.|....
Yeast   475 ST-------------------------------ADVFNWFSNIST-----------ISGFLGWMC 497

  Fly   474 RCLEPLLGR---FEPGSVVSVAVMLFIFLSFAICVELKVSWTQLYTGTWWALIIYGFIIFAAGTC 535
            .|:..|..|   |..|        |:..|.|.       :|.|.|| .|::||:.|.|....|..
Yeast   498 GCIAYLRFRKAIFYNG--------LYDRLPFK-------TWGQPYT-VWFSLIVIGIITITNGYA 546

  Fly   536 VAV 538
            :.:
Yeast   547 IFI 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	120/559 (21%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
PUT4	NP_014993.1	2A0310	107..593	CDD:273334	119/555 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960