DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and GAP1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_012965.3	Gene:	GAP1 / 853912	SGDID:	S000001747	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	430	Identity:	83/430 - (19%)
Similarity:	164/430 - (38%)	Gaps:	80/430 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 MNRTKSVPTDVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPGIILSFILAGFIS 84
            ::..:.|.....:|||...|....:.::.||..:|.|:.|.:||..:......:::.:...|.:.
Yeast    71 LSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMI 135

  Fly    85 MLAALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIGWNILLE-------HMLGAASVARAWS-- 140
            ....:...|.....|.:|....|....:.|.:.:...:|.:|:       .::.|:.....|.
Yeast   136 YAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTD 200

  Fly   141 -GYVDSMLG-GWIGNTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLV 203
             .|.|..:. .|:....:.:. |:...|.|::  |.:|:                    .::|:|
Yeast   201 PKYRDGFVALFWLAIVIINMF-GVKGYGEAEF--VFSFI--------------------KVITVV 242

  Fly   204 NIAVMVLVISVG----FWYADGKNWSEAEGGFLPYGVGGVIAGAATCF----YAFVGFDSIATSG 260
            ...::.::::.|    ..|..||.|.: .|.|.....|....|..:.|    ::|.|.:.:..:.
Yeast   243 GFIILGIILNCGGGPTGGYIGGKYWHD-PGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAA 306

  Fly   261 EEAKNPSVSIPVATVISLFVVTVGYILVSAALTLMIP--------ISEINPAAS----------- 306
            .|:..|..|:|.|.....:.:|:.|||....:.|::|        .|.::.|||
Yeast   307 SESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGI 371

  Fly   307 --LPEAFGQLNLSWAKYLISIGALCGMTTTLLGSLFALPRCMYAMASDGLLFSCFGKINPTTQVP 369
              ||..   :|:.....::|:|.         .:::|..|.|.|:|....|...|..::...: |
Yeast   372 KGLPSV---VNVVILIAVLSVGN---------SAIYACSRTMVALAEQRFLPEIFSYVDRKGR-P 423

  Fly   370 LLNLVVSGVMSACLALVFDLAKLVEFMSIGTLLAYTIVSA 409
            |:.:.|:   ||...:.|..|...|......|||.:.:|:
Yeast   424 LVGIAVT---SAFGLIAFVAASKKEGEVFNWLLALSGLSS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	82/418 (20%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
GAP1	NP_012965.3	LysP	43..601	CDD:223903	83/430 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
TreeFam	0	0.000	Not matched by this tool.
	6	5.990