DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13248 and HIP1

DIOPT Version :9

Sequence 1:	NP_649219.1	Gene:	CG13248 / 40254	FlyBaseID:	FBgn0036984	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_011707.1	Gene:	HIP1 / 853104	SGDID:	S000003423	Length:	603	Species:	Saccharomyces cerevisiae

Alignment Length:	540	Identity:	119/540 - (22%)
Similarity:	216/540 - (40%)	Gaps:	105/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DVMETPLNRCLNTFDIALLGIGHMVGAGIYVLTGTVAKEMAGPG------IILSFILAGFISMLA 87
            |:..|.|::.|:...:..|.:|..:|.|:||.|| .|....||.      :|:|..|...|:.|
Yeast    80 DINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTG-AALSTGGPASLVIDWVIISTCLFTVINSL- 142

  Fly    88 ALCYAEFGTRVPKAGSAYVYTYISMGEFWAFVIG------WNILLEHMLGAASVA-RAWSGYVDS 145
                .|.....|..|...||:...:...:||.:.      |.:||...|.|||:. :.|:..::|
Yeast   143 ----GELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWLVLLPLELVAASITIKYWNDKINS 203

  Fly   146 MLGGWIG--NTTLELTGGIHEPGLAQYPDVLAFLVCIVYAAALAGGVKATAVFNSLLTLVNIAVM 208
              ..|:.  ..|:         .||...||.:|           |..:.......:|:::...::
Yeast   204 --DAWVAIFYATI---------ALANMLDVKSF-----------GETEFVLSMIKILSIIGFTIL 246

  Fly   209 VLVISVG----FWYADGKNWSEAEGGFLPYGVGGVIAGAATCF----YAFVGFDSIATSGEEAKN 265
            .:|:|.|    ..|..||.|.: .|.|:.:..|....|..:.|    :::.|.:..|.|..|:||
Yeast   247 GIVLSCGGGPHGGYIGGKYWHD-PGAFVGHSSGTQFKGLCSVFVTAAFSYSGIEMTAVSAAESKN 310

  Fly   266 PSVSIPVATVISLFVVTVGYILVSAALTLMIPISE---INPAASLPEAFGQLNLSWAKYLISIGA 327
            |..:||.|...:.:::|..|:.:...:..::|.::   :|.::|:..|...|.::     |..|.
Yeast   311 PRETIPKAAKRTFWLITASYVTILTLIGCLVPSNDPRLLNGSSSVDAASSPLVIA-----IENGG 370

  Fly   328 LCG----MTTTLL--------GSLFALPRCMYAMASDGLLFSCFGKINPTTQVPLLNLVVSGVMS 380
            :.|    |...:|        .:::|..|||.|||..|.|.....:::...:.  :|.::..:..
Yeast   371 IKGLPSLMNAIILIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRVDKRGRP--MNAILLTLFF 433

  Fly   381 ACLALVFDLAKLVEFMS-------IGTLLAYTIVSASVIILRYRPMERIHTTIRVPAVAGSPDDD 438
            ..|:.|....|..|..:       :.|:..:..::.|.|  |:|...::             .:.
Yeast   434 GLLSFVAASDKQAEVFTWLSALSGLSTIFCWMAINLSHI--RFRQAMKV-------------QER 483

  Fly   439 DDDDEDVASQSSMDTSSPTSEMIEEVLAGRLKAQFRCLEPLLGRFEPGSVVSVAVMLFIFLSFAI 503
            ..|:....||:.:..|.....::..||   :.:.:..|.||     .||..|.......:|||.|
Yeast   484 SLDELPFISQTGVKGSWYGFIVLFLVL---IASFWTSLFPL-----GGSGASAESFFEGYLSFPI 540

  Fly   504 CVELKVSWTQLYTGTWWALI 523
            .:...|. .:|||..|..::
Yeast   541 LIVCYVG-HKLYTRNWTLMV 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13248	NP_649219.1	2A0303	32..603	CDD:273330	118/537 (22%)
CG13248	NP_649219.1	AA_permease_C	551..601	CDD:290617
HIP1	NP_011707.1	2A0310	88..567	CDD:273334	116/532 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2106
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	1	0.950	-	0	Normalized mean entropy	S2810
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46729
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
TreeFam	0	0.000	Not matched by this tool.
	10	9.750